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276篇 您的检索式:作者名="DIMOPOULOS M"
    题名 作者 年代 出处 被引量
1羟乙基淀粉溶液在复苏肠缺血-再灌注休克中的作用显示文摘目的 比较不同剂量羟乙基淀粉溶液 ( HES)对兔肠缺血再灌注损伤所致休克的复苏作用。方法 32只新西兰白兔随机分为 4组 :模型对照、乳酸林格液复苏组 ( L RS,2 0 m l· kg- 1 · h- 1 ) ,小剂量 HES复苏组 ( HES2 ml· kg- 1· h- 1 + L RS18m l· kg- 1· h- 1 ) ,大剂量 HES复苏组 ( HES2 0 ml· kg- 1· h- 1 )。采用肠系膜上动脉夹闭 6 0 m in后松夹行再灌注制备肠缺血再灌注休克模型 ,松夹再灌注时同步进行液体复苏。观测各时间点的血流动力学参数 (平均动脉压、心率、心排血量、肠系膜上动脉血流 ) ,并通过测定肠黏膜CO2 分压和动脉血 CO2 分压的差值 (动脉二氧化碳间隙 )、肠黏膜 p H值、动脉血乳酸浓度和氧输送等指标间接评估组织氧合情况。实验结束后累计动物死亡数。结果 HES能明显提高肠缺血再灌注休克时的血流动力学参数 ,与对照组和 L RS组比较差异均有显著性 ( P均 <0 .0 5 ) ;小剂量 HES比大剂量 HES改善血流动力学参数的作用更平稳 ( P均 <0 .0 5 ) ,且较其他 3组能明显降低血乳酸浓度和动脉二氧化碳间隙 ,减轻 p Hi的降低 ( P均 <0 .0 5 ) ;而大剂量 HES对上述参数的影响不明显 ,并可见动物口鼻出血及死亡 ;小剂量或大剂量HES与其他两组比较均能使氧输送回升 ( P均 <0 .0 5 )。涂自智 孙庆华 George Dimopoulos Suzana M Lobo Daniel de Backer 肖献忠 Jean-Louis Vincent 2004中国危重病急救医学2004,16,8:6
2不同液体复苏条件下多巴酚丁胺对肠缺血-再灌注休克的疗效比较显示文摘目的 比较多巴酚丁胺在不同液体复苏条件下对兔肠缺血再灌注损伤 (I/ R)所致休克的治疗效果。方法 32只新西兰白兔随机分为乳酸林格液 (L RS)复苏组、L RS+羟乙基淀粉溶液 (HES)复苏组、L RS复苏 +多巴酚丁胺治疗组 (L RS+DOB组 )和 L RS+HES复苏 +多巴酚丁胺治疗组 (L RS+HES+DOB组 )。采用肠系膜上动脉夹闭 6 0 m in后松夹行再灌注制备肠 I/ R休克模型 ,松夹再灌注时同步进行液体复苏和多巴酚丁胺治疗。观察各时间点血流动力学参数 (平均动脉压、心率、心排血量、肠系膜上动脉血流 )的变化 ,并通过测定动脉二氧化碳间隙〔 Pt a CO2 间隙 =肠黏膜 CO2 分压 (Pt CO2 ) -动脉血 CO2 分压 (Pa CO2 )〕、肠黏膜 p H值 (p Hi)、动脉血乳酸浓度和氧输送 (DO2 )等指标间接评价组织氧合情况。结果 多巴酚丁胺能显著减轻兔肠I/ R休克后平均动脉压、心率、心排血量和肠系膜上动脉血流的下降 ,两多巴酚丁胺治疗组与两复苏组比较 ,差异均有显著性 (P均 <0 .0 5 ) ;且 L RS+HES+DOB组平均动脉压下降程度较 L RS+DOB组明显减轻 (P<0 .0 5 )。与 L RS组比较 ,两多巴酚丁胺治疗组均能明显降低血乳酸浓度和 Pt a CO2 间隙 ,升高 p Hi和 DO2 (P均<0 .0 5 ) ,尤其在 L RS+HES+DOB组效果更显著 (P均 <0 .0 5 ) ,与 L涂自智 孙庆华 George Dimopoulos Suzana M Lobo DanielDe Backer 肖献忠 Jean-Louis Vincent 2005中国危重病急救医学2005,17,2:3
3Innate immune defense against malaria infection in the mosquito显示文摘Dimopoulos G Müller HM Elena A 2001Current Opinion in Immunology2001,13,1:1
4Viral epidemiology of acute exacerbations of chronic obstructive pulmonary disease 显示文摘Dimopoulos G Lerikou M Tsiodras S 2012Pulm Pharmacol Ther2012,25,1:1
5Interaction between the skeletal and immune systems in cancer: mechanisms and clinical implications显示文摘Terpos E Dimopoulos M A 2011Cancer Immunol Immunother2011,60,3:1
6A hemocyte-like cell line established from the malaria vector Anopheles gambiae expresses six prophenoloxidase genes显示文摘M(U)LLER HM DIMOPOULOS G BLASS C 1999J Biol Chem1999,274,11:1
7Treatmentof relapsed and refractory multiple myeloma in the era of novel a- gents显示文摘van de Donk NW Lokhorst HM Dimopoulos M 2011Cancer Treat Rev2011,37,4:1
8Primary dexamethasone treatment of multiple myeloma 显示文摘ALEXANIAN R DIMOPOULOS M A DELASALLE K 1992Blood1992,80,:1
9A hemocyte-like cell line established from the malaria vector Anopheles gambiae expresses sex prophenoloxidase genes 显示文摘Mu ller H M Dimopoulos G Blass C 1999J Biol Chem1999,274,11:1
10Dickkopf-1:a suitable target for the management of myeloma bone disease显示文摘GAVRIATOPOULOU M DIMOPOULOS M A CHRISTOULAS D 2009Expert Opin Ther Target2009,13,7:1
11Prevention of thalidomide-associated thrombosis in myeloma显示文摘Palumbo A Rajkumar S V Dimopoulos M A 0,,:1
12Has there been any progress made on pregnancy outcomes among women with pulmonaly arterial hypertension? 显示文摘Bedard E Dimopoulos K Gatzoulis M A 2009Eur Heart J2009,30,3:1
13Gemcitabine and vinorelbine as second-line treatment in patients with metastatic breast cancer progressing after first-line taxane-based chemotherapy: a phase Ⅱ study conducted by the Hellenic Cooperative Oncology Group 显示文摘Nicolaides C Dimopoulos M A Samantas E 2000Ann Oncol2000,11,7:1
14Recent developments in evolutionary computation for manufacturing optimization:problems, solutions, and comparisons 显示文摘Dimopoulos C Zalzala A M S 2000IEEE Trans Evolutionary Computation2000,4,2:1
15Consensus recommenda- tions for standard investigative workup:report of the International Myeloma Workshop Consensus Panel 3 显示文摘Dimopoulos M Kyle R Fermand JP 2011Blood2011,117,18:1
16International myeloma working group consensus statement and guidelines regarding the current role of imaging techniques in the diagnosis and monitoring of multiple myeloma显示文摘Dimopoulos M Terpos E Comenzo RL 2009Leukemia2009,23,:1
17Induction of systemic and therapeutic antitumor immunity using intratumoral injection of dendritic cells genetically modified to express interleukin - 12 显示文摘Alexanian R Dimopoulos M 2006Gin Cancer Res2006,159,42:1
18Treatment - related peripheral neuropathy in multiple myeloma: the challenge continues显示文摘Delforge M Blade J Dimopoulos MA 2010Lancet Oncol2010,11,11:1
19The outcome of patients with advanced pure squamous or mixed squamous and transitional urothelial carcinomas following platinum -based chemotherapy显示文摘Kastritis E Dimopoulos M A Antoniou N 2006Anticancer Res2006,26,5:1
20A hemocyte-like cell line established from the malaria vector Anopheles gambiae expresses six prophenoloxidase genes显示文摘 Dimopoulos G Blass C 1999J Biol Chem1999,274,11:1
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