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| 1 | Resolution of non-alcoholic steatohepatitis by rosuvastatin monotherapy in patients with metabolic syndrome显示文摘AIM: To investigate the effect of rosuvastatin monotherapy on non-alcoholic steatohepatitis(NASH). At present there is no effective treatment for non-alcoholic fatty liver disease or its advanced form NASH.METHODS: This prospective study included 20 biopsy proven patients with NASH, metabolic syndrome(Met S) and dyslipidaemia. Biochemical parameters of the blood of the patients and an ultrasonography of the liver were performed at baseline. Then patients receivedlifestyle advice and were treated for a 12 mo period with rosuvastatin(10 mg/d) monotherapy. Patients were re-evaluated during the study at 3 mo intervals, during which biochemical parameters of the blood were measured including liver enzymes. A repeat biopsy and ultrasonography of the liver were performed at the end of the study in all 20 patients. Changes in liver enzymes, fasting plasma glucose, serum creatinine, serum uric acid(SUA), high sensitivity C reactive protein(hs CRP) and lipid profile were assessed every 3 mo. The primary endpoint was the resolution of NASH and the secondary endpoints were the changes in liver enzyme and lipid values.RESULTS: The repeat liver biopsy and ultrasonography showed complete resolution of NASH in 19 patients, while the 20 th, which had no improvement but no deterioration either, developed arterial hypertension and substantial rise in triglyceride levels during the study, probably due to changes in lifestyle including alcohol abuse. Serum alanine transaminase, aspartate transaminase, and γ-glutamyl transpeptidase were normalised by the 3rd treatment month(ANOVA P < 0.001), while alkaline phosphatase activities by the 6th treatment month(ANOVA, P = 0.01). Fasting plasma glucose and glycated haemoglobin were significantly reduced(P < 0.001). Lipid values were normalised by the 3rd treatment month. No patient had Met S by the 9th treatment month. Body mass index and waist circumference remained unchanged during the study. Thus, changes in liver pathology and function should be attributed solely to rosuvastatin treatment. A limitation of the study is the absence of a control group.CONCLUSION: These findings suggest that rosuvastatin monotherapy could ameliorate biopsy proven NASH and resolve Met S within 12 mo. These effects and the reduction of fasting plasma glucose and SUA levels may reduce the risk of vascular and liver morbidity and mortality in NASH patients. These findings need confirmation in larger studies. | Konstantinos Kargiotis Vasilios G Athyros Olga Giouleme Niki Katsiki Evangelia Katsiki Panagiotis Anagnostis Chrysoula Boutari Michael Doumas Asterios Karagiannis Dimitri P Mikhailidis | 2015 | World Journal of Gastroenterology2015，21，25： | 18 |
| 2 | Brain stem cells as the cell of origin in glioma显示文摘Glioma incidence rates in the United States are near 20000 new cases per year, with a median survival time of 14.6 mo for high-grade gliomas due to limited therapeutic options. The origins of these tumors and their many subtypes remain a matter of investigation. Evidence from mouse models of glioma and human clinical data have provided clues about the cell types and initiating oncogenic mutations that drive gliomagenesis, a topic we review here. There has been mixed evidence as to whether or not the cells of origin are neural stem cells, progenitor cells or differentiated progeny. Many of the existing murine models target cell populations defined by lineage-specific promoters or employ lineagetracing methods to track the potential cells of origin. Our ability to target specific cell populations will likely increase concurrently with the knowledge gleaned from an understanding of neurogenesis in the adult brain. The cell of origin is one variable in tumorigenesis, as oncogenes or tumor suppressor genes may differentially transform the neuroglial cell types. Knowledge of key driver mutations and susceptible cell types will allow us to understand cancer biology from a developmental standpoint and enable early interventional strategies and biomarker discovery. | Aram S Modrek N Sumru Bayin Dimitris G Placantonakis | 2014 | World Journal of Stem Cells2014，6，1： | 12 |
| 3 | Hepatitis B-specific T helper cell responses in uninfected infants born to HBsAg^(+)/HBeAg^(-) mothers显示文摘Vertically transmitted hepatitis B virus(HBV)usually causes chronic infection.While combined active–passive immunoprophylaxis in neonates of hepatitis B surface antigen-positive(HBsAg1)mothers at birth prevents vertical transmission,it is not yet clear whether neonates encounter the virus or its products in the absence of hepatitis B e antigen(HBeAg).This study was undertaken to investigate HBV antigen-specific T-cell responses in vaccinated neonates of HBsAg1/HBeAg2 mothers.Blood was collected from 46 HBsAg1 mothers and their neonates(subjects)as well as 24 age-matched controls.All neonates of HBsAg1 mothers received appropriate immunoprophylaxis,and HBsAg and hepatitis B surface antibody(anti-HBs)antibody titers were determined after completion of the vaccination course.Peripheral blood mononuclear cells(PBMCs)from infants at birth,1 and 6 months of age were stimulated with recombinant HBsAg,hepatitis B core antigen(HBcAg)and mitogen,and interferon(IFN)-c concentrations were determined by ELISA.HBsAg-induced production of IL-2,IL-5,IL-6 and IL-10 was assessed using a cytometric bead array kit on cells from 6-month-old neonates post-vaccination.All neonates were HBsAg2 and responded to vaccination.Increased IFN-c production following HBcAg stimulation was seen in 30.4%of neonates born to HBsAg1/HBeAg2 mothers.Subjects demonstrated significantly higher IL-2 production post-HBsAg stimulation,whereas IL-5,IL-6 and IL-10 cytokine responses were not significantly different.Almost one-third of uninfected neonates developed viral antigen-induced IFN-c production,suggesting that they had been exposed to virions or viral derivatives.This encounter,however,did not impair their T-cell responses to vaccination. | Lemonica Koumbi Antonio Bertoletti Vassiliki Anastasiadou Maria Machaira Winnie Goh Nikolaos G Papadopoulos Dimitris A Kafetzis Vassiliki Papaevangelou | 2010 | Cellular & Molecular Immunology2010，7，6： | 4 |
| 4 | Athens Insomnia Scale: validation of an instrument based on ICD-10 criteria显示文摘 | Constantin R Soldatos Dimitris G Dikeos Thomas J Paparrigopoulos | 2000 | Journal of Psychosomatic Research2000，，6： | 2 |
| 5 | The role of ankle brachial index and carotid intima-media thickness in vascular risk stratification显示文摘 | Konstantinos Tziomalos Vasilios G Athyros Asterios Karagiannis Dimitri P Mikhailidis | 2010 | Current Opinion in Cardiology2010，，4： | 2 |
| 6 | Immobilization mechanisms of Pb in firing range soils using Apatite II phosphate显示文摘 | Dermatas Dimitris Grubb Dennis G Moon Deok Hyun | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 2 |
| 7 | Safety and efficacy of long-term statin treatment for cardiovascular events in patients with coronary heart disease and abnormal liver tests in the Greek Atorvastatin and Coronary Heart Disease Evaluation (GREACE) Study: a post-hoc analysis显示文摘 | Vasilios G Athyros Konstantinos Tziomalos Thomas D Gossios Theodora Griva Panagiotis Anagnostis Konstantinos Kargiotis Efstathios D Pagourelias Eleni Theocharidou Asterios Karagiannis Dimitri P Mikhailidis | 2010 | The Lancet2010，，9756： | 2 |
| 8 | Cardiovascular risk across the histological spectrum and the clinical manifestations of non-alcoholic fatty liver disease:an update显示文摘 | Vasilios G Athyros Konstantinos Tziomalos Niki Katsiki Michael Doumas Asterios Karagiannis Dimitri P Mikhailidis | 2015 | World Journal of Gastroenterology2015，，22： | 2 |
| 9 | Financial development and economic growth: evidence from panel unit root and cointegration tests显示文摘 | Dimitris K Christopoulos Efthymios G Tsionas | 2003 | Journal of Development Economics2003，，1： | 2 |
| 10 | Solitary fibrous tumor of the central nervous system:report of an additional 5cases with comprehensive literature review显示文摘 | Bisceglia M Dimitri L Giantempo G | 2011 | Int J Surg Pathol2011，19，4： | 1 |
| 11 | Investigation of mixing/segregation of mixture particles in gas-solid fluidized beds 显示文摘 | LU H L ZHAO Y H DING J M DIMITRI G LI W | 2007 | Chemical Engineering Science2007，62，12： | 1 |
| 12 | Life-cycle cost analysis of reinforced concrete structures in marine environments显示文摘 | Dimitri V Val Mark G Stewart | 2003 | Structural Safety2003，25，： | 1 |
| 13 | The role and el? cacy of retrograding nailing for the treat ment of diaphyseal and distal femoral fractures: a systematic re view of the literature显示文摘 | PAPADOKOSTAKIS G PAPAKOSTIDIS C DIMITRIOU R | 2005 | Injury2005，36，： | 1 |
| 14 | Single-anten- na coherent detection of collided FM0 RFID signals 显示文摘 | BLETSAS A KIMIONIS J DIMITRIOU A G | 2012 | IEEE Transactions on Communications2012，60，3： | 1 |
| 15 | Investigation of the Molecular Weight Increase of Commercial Lignosulfonates by Laccase Catalysis显示文摘 | Dimitri A Jiebing Li Goran G | 2010 | Biomacromolecules2010，11，： | 1 |
| 16 | Comparison of effects of theophylline and caffeine on respiratory function of prematurely born infants 显示文摘 | Laubscher B Greenough A Dimitriou G | 1998 | Early Hum Dev1998，50，2： | 1 |
| 17 | Cure kinetics of epoxy amine resins used in the restoration of works of art from glass or ceramic显示文摘 | EVRIKLEIA G K DIMITRIS IRINI SA IRINI D S | | 0，，42： | 1 |
| 18 | Early prediction of chronic oxygen dependency by lung function test results 显示文摘 | Kavvadia V Greenough A Dimitriou G | 2000 | Pediatr Pulmonol2000，29，1： | 1 |
| 19 | Synchronized mechanical ventilation for respiratory support in newborn infant 显示文摘 | Greenough A Dimitriou G Prendergast M Milner AD | 2001 | Cochrane Database Syst Rev2001，，00： | 1 |
| 20 | Behaviour of cobalt during sulphuric acid pressure leaching of a limoniic laterite显示文摘 | Dimitri Georgiou Vladimiros G Papangelakis | 2009 | Hydrometallurgy2009，，100： | 1 |
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