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| 1 | Portal vein thrombosis:Insight into physiopathology,diagnosis,and treatment显示文摘Portal vein thrombosis (PVT) is a relatively common complication in patients with liver cirrhosis, but might also occur in absence of an overt liver disease. Several causes, either local or systemic, might play an important role in PVT pathogenesis. Frequently, more than one risk factor could be identified; however, occasionally no single factor is discernable. Clinical examination, laboratory investigations, and imaging are helpful to provide a quick diagnosis, as prompt treatment might greatly affect a patient's outcome. In this review, we analyze the physiopathological mechanisms of PVT development, together with the hemodynamic and functional alterations related to this condition. Moreover, we describe the principal factors most frequently involved in PVT development and the recent knowledge concerning diagnostic and therapeutic procedures. Finally, we analyze the implications of PVT in the setting of liver transplantation and its possible influence on patients' future prognoses. | Francesca R Ponziani Maria A Zocco Chiara Campanale Emanuele Rinninella Annalisa Tortora Luca Di Maurizio Giuseppe Bombardieri Raimondo De Cristofaro Anna M De Gaetano Raffaele Landolfi Antonio Gasbarrini | 2010 | World Journal of Gastroenterology2010，16，2： | 75 |
| 2 | Plasminogen kringle 5-engineered glioma cells block migration of tumor- associated macrophages and suppress tumor vascularization and progres- sion.显示文摘 | Perri SR Nalbantoglu J Annabi B Koty Z Lejeune L Francois M Di Falco MR Beliveau R Galipeau J | 2005 | 中国神经肿瘤杂志2005，3，3： | 8 |
| 3 | Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions显示文摘 | Elizabeth M Brunt Christine G Janney Adrian M Di Bisceglie Brent A Neuschwander-Tetri Bruce R Bacon | 1999 | The American Journal of Gastroenterology1999，，9： | 3 |
| 4 | Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions显示文摘 | Elizabeth M Brunt Christine G Janney Adrian M Di Bisceglie Brent A Neuschwander-Tetri Bruce R Bacon | 1999 | The American Journal of Gastroenterology1999，，9： | 2 |
| 5 | Genetic improvement of Trichoderma ability to induce systemic resistance显示文摘The beneficial applications of Trichoderma spp. in agriculture include not only the control of plant pathogens, but also the improvement of plant growth, micronutrient availability, and plant tolerance to abiotic stress. In addition, it has been suggested that these fungi are able to increase plant disease resistance by activating induced systemic resistance (ISR) . The mode of action of these beneficial fungi in the Trichoderma -plant-pathogen interaction are many, complex and not completely understood. Numerous lytic enzymes have been characterized, the encoding genes (ech42 gluc78, nag1 from T. atroviride strain P1) cloned, and their role in biocontrol demonstrated. The corresponding biocontrol-related inducible promoters have been used in a reporter system based on the Aspergillus niger glucose oxidase gene (goxA) to monitor biocontrol activity. Glucose oxidase catalyzes the oxygen-dependent oxidation of D-glucose to D-glucono-1,5-lactone and hydrogen peroxide; this latter compound is known to have an antifungal effect and activate the plant defence cascade, thus increasing resistance to pathogen attack. T. atroviride P1 transformants with various promoters gox were tested as seed coating treatments on bean seeds planted in soil infested with a soilborne fungal pathogen. Successively, the emergent leaves were inoculated with a foliar pathogen to determine the effect of the GOX transformants on biocontrol and resistance to pathogen attack. Inoculations with the P1-GOX transformants not only reduced disease symptoms caused by a soil pathogen, but also the lesions of various foliar pathogens applied far from the Trichoderma colonization, thus activating ISR. A similar approach is being use to genetically improve T. harzianum T22, a rhizosphere competent and commercially marketed strain not transformed yet, by using four different gox gene constructs under the control of constitutive and inducible promoters. Plasmids have been introduced in Trichoderma by protoplasts co-transformation. hygromicin resistant progeny selected, and mitotically stable transformants analysed to confirm the presence of the novel enzyme activity. Progenies are being tested for biocontrol ISR inducing activity. | Ciliento R Woo S L Di Benedetto P Ruocco M Scala F Soriente I Ferraioli S Brunner K Zeilinger S Mach R L Lorito M | 2004 | 浙江大学学报(农业与生命科学版)2004，30，4： | 2 |
| 6 | Molecular cloning of three cDNAs that encode cysteine proteinases in the digestive gland of the American lobster (Homarus americanus) 显示文摘 | Laycock M V Mackay R M Di Fruscio M | 1991 | FEBS Lett1991，292，12： | 1 |
| 7 | Molecular mechanisms of acute renal failure following ischemia reperfusion显示文摘 | VRTDYRILRN A M DI - MAGGIO F LEEMREIS J R | 2004 | Int J Artif Organs2004，27，12： | 1 |
| 8 | Effect of hard second phase on cavitation erosion of Fe-Cr-Ni-C alloys显示文摘 | Cuppari V Souza R M | 2005 | Wear2005，258，： | 1 |
| 9 | Two-dimensional echocardiography estimation of right ventricular ejection fraction by wall motion score index显示文摘 | Lebeau R Di Lorenzo M Sauve C | 2004 | Can J Cardiol2004，20，2： | 1 |
| 10 | Study of liver function in healthy elderly subjects using the ^13C-methacetin breath test显示文摘 | Ciccocioppo R Candelli M Di Francesco D | 2003 | Aliment Pharmacol Ther2003，17，2： | 1 |
| 11 | The effects of pneumoperitoneum and head-up position on heart rate variability and QT interval dispersion during laparoscopic cholecystectomy 显示文摘 | Di lorio C Cafiero T Di Minno R M | 2010 | Minerva Anestesiol2010，76，11： | 1 |
| 12 | No evidence of involvement of Chlamydia pneumoniae in lung cancer by means of quantitative real-time polyrnerase chain reaction 显示文摘 | Sessa R Santino l Di Pietro M | 2008 | Int J Dnmunopathol Pharmacol2008，21，2： | 1 |
| 13 | Nitrogen recovery from a stabilized municipal landfill leachate 显示文摘 | Di Iaconi C Pagano M Ramadori R | 2010 | Bioresource Technology2010，101，6： | 1 |
| 14 | Increased activity of the ubiquitin-proteasome system in patients with symptomatic carotid disease is associated with enhanced inflammation and may destabilize the atherosclerotic plaque: effects of rosiglitazone treatment显示文摘 | Marfella R D'Amico M Di Filippo C | 2006 | J Am Coil Cardio2006，47，12： | 1 |
| 15 | Prevalence of sarcopenia and its association with osteoporosis in 313 older women following a hip fracture 显示文摘 | Di Monaco M Vallero F Di Monaco R | 2011 | Arch Gerontol Geriatr2011，52，： | 1 |
| 16 | Development of a mechanical device for concealing underground urban solid residual containers显示文摘 | DI'AZ R V SIERRA J M CORTIZO J L | 2005 | Materials and Design2005，26，： | 1 |
| 17 | Medical expulsive treatment of disialureteral stones using tamsulosin:a single center experience显示文摘 | De Sio M AU Torino R Di Lrenzo G | 2006 | J Endourol2006，20，： | 1 |
| 18 | The possible role of the ubiquitin proteasome system in the development of atherosclerosis in diabetes显示文摘 | Marfella R D'Amico M Di Filippo C | | 0，，： | 1 |
| 19 | Immunotherapy with cytokine induced killer cells in solid and hematopoietic tumours:a pilot clinical trial显示文摘 | Olioso P Giancola R Di Riti M | 2009 | Hematol Oncol2009，27，3： | 1 |
| 20 | IL-21 as a therapeutic target in inflammatory disorders显示文摘 | Di Fusco D Izzo R Figliuzzi M M | 2014 | Expert Opin Ther Targets2014，18，11： | 1 |
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