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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Photolytic debromination of decabromodiphenyl ether(BDE209)显示文摘 | Gunilla Sö derströ m Ulla Sellströ m Cynthiaa Dewit | 2004 | Environ Sci Technol2004，38，1： | 1 |
| 3 | Modified range-Doppler processing for FMCW synthetic apertureradar显示文摘 | DeWit J J M Meta A and Hoogeboom P | 2006 | IEEE Geoscience and Remote Sensing Letters2006，3，1： | 1 |
| 4 | Indentification of several pathogenesis-related proteins in tomato leaves incoluated with Cladosporium fulvum as β-1,3-glucanse and chitinase显示文摘 | Joosten M H Dewit P J | 1989 | Plant Physiol1989，89，： | 1 |
| 5 | Target volumes in radiotherapy for high-grade malig- nant glioma of the brain 显示文摘 | JANSEN E P M DEWIT L G H VAN HERK M | 2000 | Radiotherapy and Oncolo- gy2000，56，2： | 1 |
| 6 | A geometric model of alternating current etching of aluminum显示文摘 | Dewit H J Boots H M J | 1983 | J Appl Phys1983，，5： | 1 |
| 7 | Past,present and future directions in human genetic susceptibility to tuberculosis显示文摘 | Moller M Dewit E Hoal E G | | 0，，01： | 1 |
| 8 | Compensatory renal response after unilateral partial and whole volume high-dose irradiation of the human kidney显示文摘 | Dewit L Verheij M Valdes-Olmos R | 1993 | Eur J Cancer1993，，： | 1 |
| 9 | Molecular characterization of the human excision repair gene ERCC-1:cDNA cloning and a-mino acid homology with the yeast DNA repair gene RAD10显示文摘 | Van-Duin M Dewit J Odijk H | 1986 | Cell1986，44，6： | 1 |
| 10 | Identification of several pathogenesis-related proteins in tomato leaves incoluated with Cladosporium fulyam as β-1,3-glucanse and chitinase显示文摘 | Joostem M H Dewit P J | 1989 | Plant Physio11989，89，3： | 1 |
| 11 | Effect of fluconazole on indinavir pharmaeokinetics in human immunodeficiency virus-infected patients显示文摘 | DeWit S Debier M DeSmet M | 1998 | Antimicrob Agents Chemother1998，42，： | 1 |
| 12 | Identification of several pathogenesis-related proteins in tomato leaves inoculated with Cladosporium fulvum as 1,3-b-glucanases and chitinases显示文摘 | Dewit P J G M | 1989 | Plant Physiol1989，89，： | 1 |
| 13 | Gender differences in the effects of family adversity on the risk of onset of DSM-III-R social phobia显示文摘 | DeWit DJ Chandler-Coutts M Offord DR | 2005 | Journal of Anxiety Disorders2005，19，： | 1 |
| 14 | Target volumes in radiotherapy for high-grade malignant glioma of the brain显示文摘 | Jansen EPM Dewit LGH van Herk M | 2000 | Radiother Oncol2000，56，2： | 1 |
| 15 | EIS measurements on artificial blisters in organic coatings显示文摘 | VANDER W D H VANWESTING E P M DEWIT J H W | | 0，，： | 1 |
| 16 | Target volumes in radiotherapy for high-grade malignant glioma of the brain显示文摘 | Jansen EP Dewit LG van Herk M | 2000 | Radiother Oncol2000，56，2： | 1 |
| 17 | Provastatins inhibit cholesterol ester accummulation in human monocyte-derived macrophages显示文摘 | Kempen HJM Vemeer M Dewit E | 1991 | Arteropscler Thrpmb1991，11，： | 1 |
| 18 | The Impact of Interface Usability on Trust in Web Retailers 显示文摘 | Christine Roy M Dewit O Aubert BA | 2001 | In- ternet Research2001，1，5： | 1 |
| 19 | Effects of aromatic type and concentration in Fischer- Tropsch fuel on emissions production and material compatibility 显示文摘 | DEWIT M J CORPORAN E GRAHAM J | 2008 | Energy Fuels2008，22，2： | 1 |
| 20 | Weekly systemic cisplatinplus locoregional hyperthermia:an effective treatment for patientswith recurrent cervical carcinoma in a previously irradiated area显示文摘 | Franckena M DeWit R Ans ink AC | 2007 | Int J Hyperthermia2007，23，5： | 1 |
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