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| 1 | Minimally invasive surgery for gastric cancer: A comparison between robotic, laparoscopic and open surgery显示文摘AIM To investigate the role of minimally invasive surgery for gastric cancer and determine surgical, clinical, and oncological outcomes.METHODS This is a propensity score-matched case-control study, comparing three treatment arms: robotic gastrectomy(RG), laparoscopic gastrectomy(LG), open gastrectomy(OG). Data collection started after sharing a specific study protocol. Data were recorded through a tailored and protected web-based system. Primary outcomes: harvested lymph nodes, estimated blood loss, hospital stay, complications rate. Among the secondary outcomes, there are: operative time, R0 resections, POD of mobilization, POD of starting liquid diet and soft solid diet. The analysis includes the evaluation of type and grade of postoperative complications. Detailed information of anastomotic leakages is also provided.RESULTS The present analysis was carried out of 1026 gastrectomies. To guarantee homogenous distribution of cases, patients in the RG, LG and OG groups were 1:1:2 matched using a propensity score analysis with a caliper = 0.2. The successful matching resulted in a total sample of 604 patients(RG = 151; LG = 151; OG = 302). The three groups showed no differences in all baseline patients characteristics, type of surgery(P = 0.42) and stage of the disease(P = 0.16). Intraoperative blood loss was significantly lower in the LG(95.93 ± 119.22) and RG(117.91 ± 68.11) groups compared to the OG(127.26 ± 79.50, P = 0.002). The mean number of retrieved lymph nodes was similar between the RG(27.78 ± 11.45), LG(24.58 ± 13.56) and OG(25.82 ± 12.07) approach. A benefit in favor of the minimally invasive approaches was found in the length of hospital stay(P < 0.0001). A similar complications rate was found(P = 0.13). The leakage rate was not different(P = 0.78) between groups.CONCLUSION Laparoscopic and robotic surgery can be safely performed and proposed as possible alternative to open surgery. The main highlighted benefit is a faster postoperative functional recovery. | Amilcare Parisi Daniel Reim Felice Borghi Ninh T Nguyen Feng Qi Andrea Coratti Fabio Cianchi Maurizio Cesari Francesca Bazzocchi Orhan Alimoglu Johan Gagnière Graziano Pernazza Simone D'Imporzano Yan-Bing Zhou Juan-Santiago Azagra Olivier Facy Steven T Brower Zhi-Wei Jiang Lu Zang Arda Isik Alessandro Gemini Stefano Trastulli Alexander Novotny Alessandra Marano Tong Liu Mario Annecchiarico Benedetta Badii Giacomo Arcuri Andrea Avanzolini Metin Leblebici Denis Pezet Shou-Gen Cao Martine Goergen Shu Zhang Giorgio Palazzini Vito D'Andrea Jacopo Desiderio | 2017 | World Journal of Gastroenterology2017，23，13： | 17 |
| 2 | Endoplasmic reticulum stress-mediated pathways to both apoptosis and autophagy: Significance for melanoma treatment显示文摘Melanoma is the most aggressive form of skin cancer.Disrupted intracellular signaling pathways are responsible for melanoma's extraordinary resistance to current chemotherapeutic modalities. The pathophysiologic basis for resistance to both chemo- and radiation therapy is rooted in altered genetic and epigenetic mechanisms that, in turn, result in the impairing of cell death machinery and/or excessive activation of cell growth and survival-dependent pathways. Although most current melanoma therapies target mitochondrial dysregulation,there is increasing evidence that endoplasmic reticulum(ER) stress-associated pathways play a role in the potentiation,initiation and maintenance of cell death machinery and autophagy. This review focuses on the reliability of ER-associated pathways as therapeutic targets for melanoma treatment. | Mohamed Hassan Denis Selimovic Matthias Hannig Youssef Haikel Robert T Brodell Mossaad Megahed | 2015 | World Journal of Experimental Medicine2015，5，4： | 15 |
| 3 | Bimanual motor skill learning and robotic assistance for chronic hemiparetic stroke: a randomized controlled trial显示文摘Using robotic devices might improve recovery post-stroke, but the optimal way to apply robotic assistance has yet to be determined. The current study aimed to investigate whether training under the robotic active-assisted mode improves bimanual motor skill learning(biMSkL) more than training under the active mode in stroke patients. Twenty-six healthy individuals(HI) and 23 chronic hemiparetic stroke patients with a detectable lesion on MRI or CT scan, who demonstrated motor deficits in the upper limb, were randomly allocated to two parallel groups. The protocol included a two-day training on a new bimanual cooperative task, LIFT-THE-TRAY, under either the active or activeassisted modes(where assistance decreased in a pre-determined stepwise fashion) with the bimanual version of the REAplan? robotic device. The hypothesis was that the active-assisted mode would result in greater biMSkL than the active mode. The biMSkL was quantified by a speed-accuracy trade-off(SAT) before(T1) and immediately after(T2) training on days 1 and 2(T3 and T4). The change in SAT after 2 days of training(T4/T1) indicated that both HI and stroke patients learned and retained the bimanual cooperative task. After 2 days of training, the active-assisted mode did not improve biMSkL more than the active mode(T4/T1) in HI nor stroke patients. Whereas HI generalized the learned bimanual skill to different execution speeds in both the active and active-assisted subgroups, the stroke patients generalized the learned skill only in the active subgroup. Taken together, the active-assisted mode, applied in a pre-determined stepwise decreasing fashion, did not improve biMSkL more than the active mode in HI and stroke subjects. Stroke subjects might benefit more from robotic assistance when applied 'as-needed.' This study was approved by the local ethical committee(Comité d'éthique médicale, CHU UCL Namur, MontGodinne, Yvoir, Belgium;Internal number: 54/2010, Eudra CT number: NUB B039201317382) on July 14, 2016 and was registered with ClinicalTrials.gov(Identifier: NCT03974750) on June 5, 2019. | Maral Yeganeh Doost Benoît Herman Adrien Denis Julien Sapin Daniel Galinski Audrey Riga Patrice Laloux Benoît Bihin Yves Vandermeeren | 2021 | Neural Regeneration Research2021，16，8： | 3 |
| 4 | Effect of Cyclosporine on Left Ventricular Remodeling After Reperfused Myocardial Infarction显示文摘 | Nathan Mewton Pierre Croisille Gerald Gahide Gilles Rioufol Eric Bonnefoy Ingrid Sanchez Thien Tri Cung Catherine Sportouch Denis Angoulvant Gérard Finet Xavier André-Fou?t Geneviève Derumeaux Christophe Piot Hélène Vernhet Didier Revel Michel Ovize | 2010 | Journal of the American College of Cardiology2010，，12： | 2 |
| 5 | Approximation algorithms for scheduling malleable tasks under precedence constraints显示文摘 | RENAUD L DENIS T GERHARD J W | 2002 | International Journal of Foundations of Computer Science2002，13，4： | 1 |
| 6 | Spatial bandwidth extended reconstruction for digital color Fresnel holograms显示文摘 | PASCAL P PATRICE T DENIS M | | 0，，11： | 1 |
| 7 | Characterization of the chromosomal aac(6')-Iz gene of Stenotrophomonas maltophilia显示文摘 | Lambert T Ploy MC Denis F | 1999 | Antimicrob Agents Chemother1999，43，10： | 1 |
| 8 | Modeling of adaptations to physical training by using a recursive least squares algorithm显示文摘 | BUSSO T DENIS C BONNEFOY R | 1997 | J Appl Physiol1997，82，5： | 1 |
| 9 | Inverse correlation between promoter strength and excision activity in class 1 integrons显示文摘 | Jové T Da Re S Denis F | | 0，，： | 1 |
| 10 | The choice among bank debt, non-bank private debt, and public debt: evidence from new cor- porate borrowings 显示文摘 | DENIS D J MIHOV V T | 2003 | Journal of Financial Economies2003，70，1： | 1 |
| 11 | 4 -Pyridyl -9,9' - spirobifluorenes as host materials for green and sky - blue phosphorescent OLEDs显示文摘 | Srbastien T Denis T C61ine D | 2015 | J Phys Chem C2015，119，11： | 1 |
| 12 | Impurities in LiFePO4 and their Influence on material characteristics 显示文摘 | Denis Y W Donoue K Kadohata T | 2008 | J Electrochem Soc2008，155，7： | 1 |
| 13 | Electroantennogram responses of Douglas-fir seed chalcids to plant volatiles显示文摘 | Denis T Frederic M P | 1998 | J Insect Physiol1998，44，56： | 1 |
| 14 | Ruptured cerebral on-cotic aneurysm from choriocarcinoma: report of two cases and re-view of the literature 显示文摘 | Zairi F De Saint Denis T Thines L | 2011 | Acta Neurochir (Wien)2011，153，2： | 1 |
| 15 | Involvement of toll-like receptor 5 in mouse model of colonic hypersensitivity induced by neonatal maternal separation显示文摘BACKGROUND Chronic abdominal pain is the most common cause for gastroenterology consultation and is frequently associated with functional gastrointestinal disorders including irritable bowel syndrome and inflammatory bowel disease. These disorders present similar brain/gut/microbiota trialogue alterations, associated with abnormal intestinal permeability, intestinal dysbiosis and colonic hypersensitivity(CHS). Intestinal dysbiosis can alter colon homeostasis leading to abnormal activation of the innate immunity that promotes CHS, perhaps involving the toll-like receptors(TLRs), which play a central role in innate immunity.AIM To understand the mechanisms between early life event paradigm on intestinal permeability, fecal microbiota composition and CHS development in mice with TLRs expression in colonocytes.METHODS Maternal separation model(NMS) CHS model, which mimics deleterious events in childhood that can induce a wide range of chronic disorders during adulthood were used. Colonic sensitivity of NMS mice was evaluated by colorectal distension(CRD) coupled with intracolonic pressure variation(IPV) measurement. Fecal microbiota composition was analyzed by 16S rRNA sequencing from weaning to CRD periods. TLR mRNA expression was evaluated in colonocytes.Additionally, the effect of acute intrarectal instillation of the TLR5 agonist flagellin(FliC) on CHS in adult naive wildtype mice was analyzed.RESULTS Around 50% of NMS mice exhibited increased intestinal permeability and CHS associated with intestinal dysbiosis, characterized by a significant decrease of species richness, an alteration of the core fecal microbiota and a specific increased relative abundance of flagellated bacteria. Only TLR5mRNA expression was increased in colonocytes of NMS mice with CHS. Acute intrarectal instillation of FliC induced transient increase of IPV, reflecting transient CHS appearance.CONCLUSION Altogether, these data suggest a pathophysiological continuum between intestinal dysbiosis and CHS, with a role for TLR5. | Geoffroy Mallaret Amandine Lashermes Mathieu Meleine Ludivine Boudieu Julie Barbier Youssef Aissouni Agathe Gelot Benoit Chassaing Andrew T Gewirtz Denis Ardid Frederic Antonio Carvalho | 2022 | World Journal of Gastroenterology2022，28，29： | 1 |
| 16 | Characterization of the chromosomally (6') -Iz gene of of Stenotrophonomas maltophilia 显示文摘 | Lambert T Ploy M C Denis F | 2000 | J Antimicrob Chemother2000，46，6： | 1 |
| 17 | Sacral fractures : an important problem retrospective analysis of 236 cases 显示文摘 | Denis F Davis S Comfort T | 1988 | Clin Orthop1988，227，： | 1 |
| 18 | Managerial Discipline and Corporate Restructuring Following Performance Declines显示文摘 | DENIS D KRUSE T | 2000 | Journal of Financial Economics2000，55，： | 1 |
| 19 | Characterization of the chromosomal aac(6')Iz gene of Stenotrophomonas mahophilia 显示文摘 | Lambert T Ploy MC Denis F | 1999 | Antimicrob Agents Chemother1999，43，10： | 1 |
| 20 | Reliability versus performance for critical applications显示文摘 | ALAIN G I~RIK S DENIS T | 2009 | Journal of Parallel and Distributed Computing2009，69，3： | 1 |
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