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| 1 | In vitro effect of pantoprazole on lower esophageal sphincter tone in rats显示文摘AIM:To investigate the in vitro effects of pantoprazole on rat lower esophageal sphincter(LES)tone.METHODS:Rats weighing 250-300 g,provided by the Yeditepe University Experimental Research Center(Yü-DETAM),were used throughout the study.They were anesthetized before decapitation.LES tissues whose mucosal lining were removed were placed in a stan-dard 30-mL organ bath with a modif ied Krebs solution and continuously aerated with 95% oxygen-5% carbon dioxide gas mixture and kept at room temperature.The tissues were allowed to stabilize for 60 min.Sub-sequently,the contractile response to 10-6 mol/L carba-chol was obtained.Different concentrations of freshly prepared pantoprazole were added directly to the tis-sue bath to generate cumulative concentrations of 5×10-6 mol/L,5×10-5 mol/L,and 1.5×10-4 mol/L.Activi-ties were recorded on an online computer via a 4-channeltransducer data acquisition system using the software BSL PRO v 3.7,which also analyzed the data.RESULTS:Pantoprazole at 5×10-6 mol/L caused a small,but statistically insignif icant,relaxation in the car-bachol-contracted LES(2.23% vs 3.95%).The 5×10-5 mol/L concentration,however,caused a signif icant relax-ation of 10.47% compared with the control.1.5×10-4 mol/L concentration of pantoprazol caused a 19.89% relaxation in the carbachol contracted LES(P<0.001).CONCLUSION:This is the fi rst study to demonstrate that pantoprazole has a relaxing effect in isolated LESs.These results might have signif icant clinical implications for the subset of patients using proton pump inhibitors who do not receive full symptomatic alleviation from gastroesophageal reflux disease. | Mustafa Duman Mahmut zer Enver Rean Yeliz Demirci Ali E Atιcι Tahsin Dalgι Erdal B Bostancι Ece Gen | 2011 | World Journal of Gastroenterology2011，17，46： | 3 |
| 2 | Goseki grade and tumour location influence survival of patients with gastric cancer显示文摘 | Calik M Calik I Demirci E | 2014 | Asian Pac J Cancer Prev: APJCP2014，15，： | 1 |
| 3 | The Bakri balloon for the man- agement of postpartum hemorrhage in cases with placenta previa 显示文摘 | Kumru P Demirci O Erdogdu E | 2013 | Eur J 0bstet Gynecol Repmd Biol2013，167，2： | 1 |
| 4 | Comparison of resuits of different surgical, techniques in the management of hydatid cysts of the liver显示文摘 | DEMIRCI S ERASLN S ANADOL E | 1989 | World J Surg1989，13，1： | 1 |
| 5 | Evaluation of the inferior turbinate in patients with deviated nasal septum by using computed tomography显示文摘 | Egeli E Demirci 1 Yazycy B | | 0，，01： | 1 |
| 6 | Acute myocardial infarction and renal infarction in a bodybuilder using anabolic steroids显示文摘 | Ilhan E Demirci D G ven c TS | | 0，，： | 1 |
| 7 | Ten - year resuhs of Marshall Marchetti Krantz and anterior colporraphy procedures 显示文摘 | DEMIRCI F YILDIRIM U DEMIRCI E | 2002 | Aust J Obstet Gynaecol2002，42，5： | 1 |
| 8 | Simulation modelling and analysis of a port investment 显示文摘 | DEMIRCI E | 2003 | Simulation2003，79，2： | 1 |
| 9 | High temperature wear behavior of aluminum oxide layers pro- duced by AC micro arc oxidation显示文摘 | ARSLAN E TOTIK Y DEMIRCI E E | 2009 | Surface and Coatings Technology2009，204，67： | 1 |
| 10 | PET-CT guided curative conformal radiation therapy in limited stage small cell lung cancer显示文摘 | Ulger S Demirci NY Aydinkarahaliloglu E | 2015 | J Thorac Dis2015，7，3： | 1 |
| 11 | Tubeless pereutaneous nephrolithotomy:safe even in supracostal access显示文摘 | Sofikerim M Demirci D Hurl E | 2007 | J Endourol2007，21，9： | 1 |
| 12 | The Bakri balloon for the management of postpartum hemorrhage in cases with placenta previa显示文摘 | KUMRU P DEMIRCI O ERDOGDU E | 2013 | European Journal of Obstetrics & Gynecology and Reproductive Biology2013，167，2： | 1 |
| 13 | Spastic paraparesis asso- ciated with porta显示文摘 | Demirci M Tan E Elibol B | 1992 | Neurology1992，42，5： | 1 |
| 14 | Clinicopathological importance of Ki-67, p27, and p53 expression in gastric cancer显示文摘 | Calik M Demirci E Altun E | 2015 | Turk J Med Sci2015，45，1： | 1 |
| 15 | High temperature wear behavior of aluminum oxide layers produced by AC micro- arc oxidation显示文摘 | ARSLAN E TOTIK Y DEMIRCI E E | 2009 | Surface and Coatings Technology2009，204，67： | 1 |
| 16 | Tubeless percutaneous nephrolithotomy:safe even in supracostal access显示文摘 | Sofikerim M Demirci D Huri E | 2007 | J Endourol2007，21，9： | 1 |
| 17 | Investigationof wear,corrosion and tribocorrosion properties of AZ91Mg alloy coated by micro arc oxidation process in the dif-ferent electrolyte solutions 显示文摘 | Demirci E E Arslan E Ezirmik K V | 2013 | Thin Solid Films2013，528，： | 1 |
| 18 | Evaluation of the inferior turbinate in patients with deviated nasal septum by using computed tomography显示文摘 | Egeli E Demirci L Yazycy B | 2004 | Laryngoscope2004，114，1： | 1 |
| 19 | The Bakri balloon for the management of postpartum hemorrhage in cases with placenta previa显示文摘 | Kumru P Demirci O Erdogdu E | 2013 | Eur J Obstet Gynecol Reprod Biol2013，167，2： | 1 |
| 20 | Emergency peripartum Hyslerectomy in a tertiary obstetric center:nine years evaluation显示文摘 | Demirci O Tugrul AS Yilmaz E | 2011 | J Obstct Gynaecol Res2011，37，8： | 1 |
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