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| 1 | Pain sensation in pancreatic diseases is not uniform: The different facets of pancreatic pain显示文摘AIM: To systematically characterize specific pain patterns in the most frequent pancreatic diseases.METHODS: Pain in patients with chronic pancreatitis(n = 314), pancreatic cancer(n = 469), and other pancreatic tumors(n = 249) including mucinous(n = 20) and serous cystadenoma(n = 31), invasive(n = 37) and non-invasive intraductal papillary mucinous neoplasia(IPMN; n = 48), low stage(n = 18) and high stage neuroendocrine neoplasia(n = 44), and ampullary cancer(n = 51) was registered and correlated with clinicopathological data. Survival times were estimated by the Kaplan-Meier method. Patients alive at the follow-up time were censored. Survival curves were compared statistically using the log-rank test.RESULTS: Forty-nine point one percent of pancreatic cancer patients revealed no pain, whereas in chronic pancreatitis only 18.3% were pain free. In contrary, moderate/severe pain was registered in 15.1% in pancreatic cancer patients that was increased in chronic pancreatitis with up to 34.2%. Serous cystadenoma was asymptomatic in most cases(58.1%), whereas 78.9% of all mucinous cystadenoma patients suffered pain. In neuroendocrine neoplasia pain was not a key clinical symptom since 64% of low stage neuroendocrine neoplasia and 59% of high stage neuroendocrine neoplasia patients were pain free. Cancer localization in the pancreatic body and patients with malignant pancreatic neoplasms were associated with more severe pain. Tumor grading and stage did not show any impact on pain. Only in pancreatic cancer, pain was directly associated with impaired survival.CONCLUSION: Pancreatic pain depicts different patterns of abdominal pain sensation according to the respective pancreatic disorder and does not allow a unification of the term pancreatic pain. | Jan G D'Haese Mark Hartel Ihsan Ekin Demir Ulf Hinz Frank Bergmann Markus W Büchler Helmut Friess Güralp O Ceyhan | 2014 | World Journal of Gastroenterology2014，20，27： | 8 |
| 2 | Pancreatic Enzyme Replacement Therapy in Patients With Exocrine Pancreatic Insufficiency Due to Chronic Pancreatitis: A 1-Year Disease Management Study on Symptom Control and Quality of Life显示文摘 | Jan G. D’Haese Güralp O. Ceyhan Ihsan Ekin Demir Peter Layer Waldemar Uhl Matthias L?hr Reinhard Rychlik Konstantinos Pirilis York Z?llner Birgit Gradl Douglas Foerster Julia M?bius Friederike Henniges Helmut Friess | 2014 | Pancreas2014，，： | 2 |
| 3 | Biochemical indicators and cardiac function tests in chronic alcohol abusers显示文摘 | Avsaroglu D Inal TC Demir M | 2005 | Croat Med J2005，46，2： | 1 |
| 4 | The Early Pleistocene development of the Gediz River, Western Turkey : An uplift - driven, climate - controlled system? 显示文摘 | Maddy D Demir T Bridgland R D | 2008 | Quaternary International2008，189，： | 1 |
| 5 | An approximate dynamic programming approach to multidimensional knapsack problems显示文摘 | Bertsimas D Demir R | 2002 | Management Science2002，48，4： | 1 |
| 6 | Treatment options in painful chronic pancreatitis: a systematic review显示文摘 | Jan G. D’Haese Güralp O. Ceyhan Ihsan Ekin Demir Elke Tieftrunk Helmut Friess | 2014 | HPB2014，，6： | 1 |
| 7 | Comparisons of short and long hedge performance:the case of Taiwan显示文摘 | Demirer R Lien D Shaffer D R | 2005 | Journal of Multinational Financial Management2005，15，1： | 1 |
| 8 | Clinical evaluation of platelet-rich plasma and bioactive glass in the treatment of intra-bony defects显示文摘 | Demir B Sengun D Berberoglu A | | 0，，： | 1 |
| 9 | Comparison of influence of different manu- facturing methods on the cleaning efficiency of rotary nickel - titanium files 显示文摘 | Celik D Ta~demir T Er K | 2013 | Microsc Res Tech2013，76，3： | 1 |
| 10 | Complications of arteriove- nous fistula with polytetraflouroethylen grafts in hemodialysis pa- tients显示文摘 | Demir D Ceviker K Aydin MS | 2015 | Niger J Clin Pract2015，18，1： | 1 |
| 11 | Psychological consequences of bullying for hospital and aged care nurses显示文摘 | Rodwell J Demir D | 2012 | Int Nurs Rev2012，59，4： | 1 |
| 12 | Fractalkine/CX3CR1: why a single chemokine-receptor duo bears a major and unique therapeutic potential显示文摘 | Jan G D’Haese Ihsan Ekin Demir Helmut Friess Güralp O Ceyhan | 2010 | Expert Opinion on Therapeutic Targets2010，，2： | 1 |
| 13 | Biochemical indicators and cardiac: function tests in chronic alcohol abusers显示文摘 | Avsaroglu D Inal T C Demir M | 2005 | Croat Med2005，46，2： | 1 |
| 14 | Survival benefit of post-mastec- tomy radiotherapy in breast carcinoma padents with T1-2 tumor and 1-3 axillary lymph node(s) metastasis显示文摘 | Duraker N Demir D Bad B | 2012 | Jpn J Clin Oncol2012，42，7： | 1 |
| 15 | The effects of ventila ted and non--ventilated nasal packs on Eustachian tube func tion: nine--step inflation-- deflation test results显示文摘 | Karahatay S Birkent H Demir D | 2006 | Rhinolo gy2006，44，197： | 1 |
| 16 | Post-treatment of anaerobically treated medium-age landfill leachate 显示文摘 | Akkaya E Demir A Karadag D | 2010 | Environmental Progress & Sustainable Energy2010，29，1： | 1 |
| 17 | The Binding Interface between Human APOBEC3F and HIV-1 Vif Elucidated by Genetic and Computational Approaches显示文摘 | Richards C Albin J S Demir O Shaban N M Luengas E M Land A M Anderson B D Holten J R Anderson J S Harki D A Amaro R E Harris R S | 2015 | Cell Rep2015，13，9： | 1 |
| 18 | Influence of surface modification of fillers and polymer on flammability and tensile behaviour of polypropylene-composites显示文摘 | Demir H Balkose D Ulku S | 2006 | Polymer Degradation and Stability2006，91，5： | 1 |
| 19 | Influence of surface modification of fillers and polymer on flammability and tensile behaviour of polypropylene - composites显示文摘 | Demir H Balkose D illktl S | 2006 | Polym Degrad Stab2006，91，5： | 1 |
| 20 | Synergistic effect of natural zeolitus on flame retardant additives显示文摘 | Demir H Arkis E Balkose D | 2005 | Polymer Degradation and Stability2005，89，3： | 1 |
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