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| 1 | Phase Ⅰ of cardiac rehabilitation:A new challenge for evidence based physiotherapy显示文摘Cardiac rehabilitation protocols applied during the inhospital phase(phaseⅠ)are subjective and their results are contested when evaluated considering what should be the three basic principles of exercise prescription:specificity,overload and reversibility.In this review,we focus on the problems associated with the models of exercise prescription applied at this early stage in-hospital and adopted today,especially the lack of clinical studies demonstrating its effectiveness.Moreover,we present the concept of'periodization'as a useful tool in the search for better results. | Rafael Michel de Macedo JoséRocha Faria-Neto Costantino Ortiz Costantini Dayane Casali Andrea Pires Muller Costantino Roberto Costantini Katherine Athayde Teixeira de Carvalho Luiz César Guarita-Souza | 2011 | World Journal of Cardiology2011，3，7： | 11 |
| 2 | Reliability in endoscopic diagnosis of portal hypertensive gastropathy显示文摘AIM: To analyze reliability among endoscopists in diagnosing portal hypertensive gastropathy (PHG) and to determine which criteria from the most utilized classifications are the most suitable. METHODS: From January to July 2009, in an academic quaternary referral center at Santa Casa of S o Paulo Endoscopy Service, Brazil, we performed this singlecenter prospective study. In this period, we included 100 patients, including 50 sequential patients who had portal hypertension of various etiologies; who were previously diagnosed based on clinical, laboratory and imaging exams; and who presented with esophageal varices. In addition, our study included 50 sequentialpatients who had dyspeptic symptoms and were referred for upper digestive endoscopy without portal hypertension. All subjects underwent upper digestive endoscopy, and the images of the exam were digitally recorded. Five endoscopists with more than 15 years of experience answered an electronic questionnaire, which included endoscopic criteria from the 3 most commonly used Portal Hypertensive Gastropathy classifications (McCormack, NIEC and Baveno) and the presence of elevated or flat antral erosive gastritis. All five endosco- pists were blinded to the patients' clinical information, and all images of varices were deliberately excluded for the analysis. RESULTS: The three most common etiologies of portal hypertension were schistosomiasis (36%), alcoholic cirrhosis (20%) and viral cirrhosis (14%). Of the 50 patients with portal hypertension, 84% were Child A, 12% were Child B, 4% were Child C, 64% exhibited previous variceal bleeding and 66% were previously endoscopic treated. The endoscopic parameters, presence or absence of mosaic-like pattern, red point lesions and cherry-red spots were associated with high inter-observer reliability and high specificity for diagnosing Portal Hypertensive Gastropathy. Sensitivity, specificity and reliability for the diagnosis of PHG (%) were as follows: mosaic-like pattern (100; 92.21; High); fine pink speckling (56; 76.62; Unsatisfactory); superficial reddening (69.57; 66.23; Unsatisfactory); red-point lesions (47.83; 90.91; High); cherry-red spots (39.13; 96.10; High); isolated red marks (43.48; 88.31; High); and confluent red marks (21.74; 100; Unsatisfactory). Antral elevated erosive gastritis exhibited high reliability and high specificity with respect to the presence of portal hypertension (92%) and the diagnosis of portal hypertensive gastropathy (88.31%). CONCLUSION: The most suitable endoscopic criteria for the diagnosis of PHG were mosaic-like pattern, redpoint lesions and cherry-red spots with no subdivisions,which were associated with a high rate of inter-observer reliability. | George Fred Soares de Macedo Fabio Gon alves Ferreira Maurício Alves Ribeiro Luiz Arnaldo Szutan Mauricio Saab Assef Lucio Giovanni Battista Rossini | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，7： | 9 |
| 3 | Lymphocyte subsets predictive value and possible involvement of human papilloma virus infection on breast cancer molecular subtypes显示文摘AIM To detect human papilloma virus(HPV) presence and to characterize cellular immune response in breast cancer patients. METHODS A total of 74 women were included, of which 48 samples were from patients diagnosed with breast cancer and 26 patients with benign pathology of the breast. Molecular subtype classification was performed based on the immunohistochemical reports of the tumor piece. HPV genome detection and genotyping from fresh breast biopsies was performed using the INNO-LIPA HPV Genotyping Extra test(Innogenetics, Ghent, Belgium). CD3+, CD4+, CD8+ and natural killer(NK)+ cells levels from peripheral blood samples from patients with breast cancer and benign pathology were measured by flow cytometry. RESULTS Luminal A was the most frequent breast cancer molecular subtype(33.33%). HPV was detected in 25% of the breast cancer patients, and genotype 18 was the most frequent in the studied population. The mean of CD3+, CD4+ and CD8+ subpopulations were decreased in patients with breast cancer, in relation to those with benign pathology, with a statistically significant difference in CD8+ values(P = 0.048). The mean of NK+ cells was increased in the benign pathology group. The average level of CD3+, CD4+, CD8+ and NK+ cells decreased as the disease progressed. HER2+ and Luminal B HER2+ tumors had the lowest counts of cell subsets. HPV breast cancer patients had elevated counts of cellular subsets. CONCLUSION Determining level changes in cellular subsets in breast cancer patients is a useful tool to evaluate treatment response. | Andreína Fernandes Adriana Pesci-Feltri Isabel García-Fleury Marco López Vincent Guida Marisol De Macedo María Correnti | 2018 | World Journal of Clinical Oncology2018，9，7： | 5 |
| 4 | Femtosecond laser-assisted deep anterior lamellar keratoplasty in phototherapeutic keratectomy versus the big-bubble technique in keratoconus显示文摘AIM:To compare the functional and anatomic results of femtosecond laser(FSL)-assisted deep anterior lamellar keratoplasty(DALK) associated with phototherapeutic keratectomy(PTK) and FSL-assisted DALK performed using the big-bubble technique in keratoconus.METHODS:During the first phase of the study,an electron microscopy histopathology pilot study was conducted that included four unsuitable donor corneas divided into two groups:in FSL group,FSL lamellar cuts were performed on two corneas and in FSL+PTK group,PTK was performed at the stromal beds of two corneas after FSL lamellar cuts were made.During the second phase of the study,a randomized clinical trial was conducted that included two treatment groups of patients with keratoconus:group 1(n=14 eyes) underwent FSL-assisted DALK associated with PTK and group 2(n=12 eyes) underwent FSL-assisted DALK associated with the bigbubble technique.The main outcome measures were the postoperative visual acuity(VA) and optical coherence tomography(OCT) measurements,confocal microscopic findings,and contrast sensitivity.RESULTS:In the pilot study,histopathology showed a more regular stromal bed in the FSL+PTK group.In the clinical trial,group 1 had significantly worse best spectaclecorrected VA and contrast sensitivity(P<0.05 for both comparisons).The residual stromal bed measured by OCT was significantly(P<0.05) thicker in group 1.Confocal microscopy detected opacities only at the donor-receptor interface in group 1.CONCLUSION:Patients with keratoconus treated with FSL-assisted DALK performed using the big-bubble technique fare better than treated with FSL-assisted DALK associated with PTK. | Jarbas Pereira de Macedo Lauro Augusto de Oliveira Flavio Hirai Luciene Barbosa de Sousa | 2018 | International Journal of Ophthalmology(English edition)2018，11，5： | 2 |
| 5 | Therapeutic and biological activities of Calotropis procera(Ait.) R.Br.显示文摘Medicinal plants have been used to treat various ailments of the poor population around the world;hence the interest among researchers to know the active ingredients of certain plants has being increased.The Calotropis procera(C.procera) is a plant original from Africa,commonly found in northeastern Brazil.It is well known for their pharmacological properties,since it produces large amounts of latex.The important role that medicinal plants play in folk medicine has led us to develop this article in order to review the major pharmacological activities of C. procera. | Marcia Calheiros Chaves Silva Antonio Batista da Silva Fabiano Moura Teixeira Paulo Cesar Pereira de Sousa Regina Maria Macedo Rondon Jose Eduardo Ribeiro Honorio Junior Luiz Rafael Leite Sampaio Samanda Lima Oliveira Angela Nadyla Martins Holonda Silvania Maria Mendes de Vasconcelos | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，4： | 2 |
| 6 | Detection of contaminants in cell cultures, sera and trypsin显示文摘 | Tatiana Flávia Pinheiro de Oliveira Ant?nio Augusto Fonseca Marcelo Fernandes Camargos Anapolino Macedo de Oliveira Ana Cláudia Pinto Cottorello Antonizete dos Reis Souza Iassudara Garcia de Almeida Marcos Bryan Heinemann | 2013 | Biologicals2013，，6： | 2 |
| 7 | Scientific Collaboration in Biotechnology : the Case of the Northeast Region in Brazil 显示文摘 | Costa B M G da Silva Pedro E de Macedo G R | 2013 | Scientometrics2013，，： | 1 |
| 8 | Neurosyphilis presenting as mania显示文摘 | Barbosa IG Vale TC de Macedo DL | 2012 | Bipolar Dsiord2012，14，： | 1 |
| 9 | DETERMINATION OF CHLORFENVINPHOS, FIPRONIL, AND CYPERMETHRIN RESIDUES IN MEAT AND BOVINE FAT USING QUECHERS METHOD AND GAS CHROMATOGRAPHY-MASS SPECTROMETRY显示文摘 | NatáliaCecília Sartarelli AdrianaNori de Macedo JulianaPane de Sousa AnaRita de Araujo Nogueira SilviaHelena Govoni Brondi | 2012 | Journal of Liquid Chromatography & Related Technologies2012，，13： | 1 |
| 10 | Spinodal decomposition mechanism study on the duplex stainless steel UNSS31803 using ultrasonic speed measurements 显示文摘 | Victor Hugo C de Albuquerque Edgard de Macedo Silv Josinaldo Pereira Leile | 2010 | Materials and Design2010，31，： | 1 |
| 11 | Prediction of success in external cephalic version under toco- lysis: still a challenge显示文摘 | VAZ DE MACEDO C CLODE N MENDES DA GRA A L | 2015 | Acta Medica Portuguesa2015，28，5： | 1 |
| 12 | Characterization of the isoprenoid chain of coenzyme Q in Plasmodium falci- parum显示文摘 | de Macedo CS Uhrig ML Kimura EA | 2002 | FEMS Mierobiol Lett2002，207，1： | 1 |
| 13 | Reattachment of anterior teeth fragments:a conservative approach显示文摘 | Macedo GV Diaz PI De O | 2008 | J Esthet Restor Dent2008，20，1： | 1 |
| 14 | Investigation of pyridine sorption in USY and Ce/USY zeolites by liquid phase mierocalorimetry and thermogravimetry studies 显示文摘 | Ghesti G F de Macedo J L Parente V C I | 2007 | Microporous and mesoporous materials2007，100，1： | 1 |
| 15 | Laparoscopic sleeve gastrectomy with ileal interposition ('neuroendocrine brake')-pilot study of a new operation显示文摘 | de Paula AL Macedo AL Prudente AS | 2006 | Surg Obes Relat Dis2006，2，4： | 1 |
| 16 | In vitro activation of the hemolysin in Prevotella nigrescens ATCC 33563 and Prevotella intermedia ATCC 25611 显示文摘 | Silva TA Noronha FS de Macedo Farias L | 2004 | Res Microbiol2004，155，1： | 1 |
| 17 | The role of innate immune receptors in the control of Brucella abortus infec- tion: Toll- like receptors and beyond 显示文摘 | Oliveira S C de Oliveira F S Macedo G C | 2008 | Microbes and In- fection2008，10，9： | 1 |
| 18 | Trypsininhibitor from Dimorphandra mollis seeds: purification andproperties显示文摘 | Macedo M L de Matos D G Manhado 0 L | 2000 | Phytochemistry2000，54，6： | 1 |
| 19 | Impact of biodegradation of organic matters on ammonia oxidation in compost显示文摘 | Yang Zeng Amaury De Guardia Christine Ziebal Flávia Junqueira De Macedo Patrick Dabert | 2013 | Bioresource Technology2013，，： | 1 |
| 20 | Selection of A1resistance Plants from a sensitire rice cultivar,using somaclonal variation,in vitro and hydroponic cultures显示文摘 | Sint JanV van Costa de Macedo C Kinet J M | 1997 | Euphytica1997，3，： | 1 |
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