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| 1 | Immune response in COVID-19:addressing a pharmacological challenge by targeting pathways triggered by SARS-CoV-2显示文摘To date,no vaccines or effective drugs have been approved to prevent or treat COVID-19 and the current standard care relies on supportive treatments.Therefore,based on the fast and global spread of the virus,urgent investigations are warranted in order to develop preventive and therapeutic drugs.In this regard,treatments addressing the immunopathology of SARS-CoV-2 infection have become a major focus.Notably,while a rapid and well-coordinated immune response represents the first line of defense against viral infection,excessive inflammatory innate response and impaired adaptive host immune defense may lead to tissue damage both at the site of virus entry and at systemic level.Several studies highlight relevant changes occurring both in innate and adaptive immune system in COVID-19 patients.In particular,the massive cytokine and chemokine release,the so-called“cytokine storm”,clearly reflects a widespread uncontrolled dysregulation of the host immune defense.Although the prospective of counteracting cytokine storm is compelling,a major limitation relies on the limited understanding of the immune signaling pathways triggered by SARS-CoV-2 infection.The identification of signaling pathways altered during viral infections may help to unravel the most relevant molecular cascades implicated in biological processes mediating viral infections and to unveil key molecular players that may be targeted.Thus,given the key role of the immune system in COVID-19,a deeper understanding of the mechanism behind the immune dysregulation might give us clues for the clinical management of the severe cases and for preventing the transition from mild to severe stages. | Michele Catanzaro Francesca Fagiani Marco Racchi Emanuela Corsini Stefano Govoni Cristina Lanni | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 11 |
| 2 | Quantum simulations of materials on near-term quantum computers显示文摘Quantum computers hold promise to enable efficient simulations of the properties of molecules and materials;however,at present they only permit ab initio calculations of a few atoms,due to a limited number of qubits.In order to harness the power of near-term quantum computers for simulations of larger systems,it is desirable to develop hybrid quantum-classical methods where the quantum computation is restricted to a small portion of the system.This is of particular relevance for molecules and solids where an active region requires a higher level of theoretical accuracy than its environment.Here,we present a quantum embedding theory for the calculation of strongly-correlated electronic states of active regions,with the rest of the system described within density functional theory.We demonstrate the accuracy and effectiveness of the approach by investigating several defect quantum bits in semiconductors that are of great interest for quantum information technologies.We perform calculations on quantum computers and show that they yield results in agreement with those obtained with exact diagonalization on classical architectures,paving the way to simulations of realistic materials on near-term quantum computers. | He Ma Marco Govoni Giulia Galli | 2020 | npj Computational Materials2020，，1： | 3 |
| 3 | The cyclooxygenase-2 inhibitor SC58236 is neuroprotective in an in vivo model of focal ischemia in the rat显示文摘 | Govoni S Masoero E Favalli L | 2001 | Neurosci Lett2001，3，2： | 1 |
| 4 | The epidemiology of alcoholic liver disease显示文摘 | Mann RE Smart RG Govoni R | 2003 | Alcohol Res Health2003，27，3： | 1 |
| 5 | SAPHO syndrome and infections显示文摘 | Govoni M Colina M Massara A | 2009 | Autoimmun Rev2009，8，3： | 1 |
| 6 | Incidence of status epilepticus in southern Europe: a population study in the health district of Ferrara, Italy显示文摘 | Govoni V Fallica E Monetti VC | 2008 | Eur Neurol2008，59，34： | 1 |
| 7 | The physiology of digestion in fish larvae显示文摘 | Govoni J J Boehlert G W Watanabe Y | 1986 | Envir Biol Fishes1986，16，： | 1 |
| 8 | p63 is an essential pro- apoptotie protein during neural development 显示文摘 | Jacobs WB Govoni G Ho D | 2005 | Neuron2005，，48： | 1 |
| 9 | DETERMINATION OF CHLORFENVINPHOS, FIPRONIL, AND CYPERMETHRIN RESIDUES IN MEAT AND BOVINE FAT USING QUECHERS METHOD AND GAS CHROMATOGRAPHY-MASS SPECTROMETRY显示文摘 | NatáliaCecília Sartarelli AdrianaNori de Macedo JulianaPane de Sousa AnaRita de Araujo Nogueira SilviaHelena Govoni Brondi | 2012 | Journal of Liquid Chromatography & Related Technologies2012，，13： | 1 |
| 10 | The epidemiology of alcoholicliver disease显示文摘 | Mann RE Smart RG Govoni R | 2003 | Alcohol Res Health2003，27，3： | 1 |
| 11 | Clinical and radiologic evolution of synovitis,acne,pustulosis,hyperostosis,and osteitis syndrome:a single center study of a cohort of 71subjects显示文摘 | Colina M Govoni M Orzincolo C | 2009 | Arthritis Rheum2009，61，6： | 1 |
| 12 | Human cytomegalovirus morphogenesis : an ultrastructural study of the late cytoplasmic phases 显示文摘 | Severi B Landini MP Govoni E | 1988 | Arch Virol1988，98，12： | 1 |
| 13 | Sex after stroke, A CNS only dys- function? 显示文摘 | Pistoia F Govoni S Boselli C | 2006 | Pharmacol Res2006，54，1： | 1 |
| 14 | Optimizing clinical monitoring of central nervous system involvement in SLE显示文摘 | Castellino G Govoni M Giacuzzo S | 2008 | Autoimmun Rev2008，7，4： | 1 |
| 15 | The epidemiology of alcohol liver disease显示文摘 | Mann RE Smart RG Govoni R | 2003 | Alcohol Res Health2003，27，3： | 1 |
| 16 | Depression and antidepressants:molecular and cellular aspects显示文摘 | Lanni C Govoni S Lucchelli A | 2009 | Cell Mol Life Sci2009，66，： | 1 |
| 17 | An Analysis of Selected Ice Accretion Measurements on a Wire at Mount Washington 显示文摘 | MCCOMBER P GOVONI J W | 1985 | Proceedings of the Forty-second Annual Eastern Snow Conference Montreal Canada1985，，： | 1 |
| 18 | The cyclooxygenase-2 inhibitor SC58236 is neuroprotective in an in vivo model of focal ischemia in the rat显示文摘 | Govoni S Masoero E Favalli L | 2001 | Neurosci Lett2001，303，2： | 1 |
| 19 | Effects of Dissolved and Colloidal Substances on Flocculation of Mechanical Pulps显示文摘 | Dunham A J Tubergen K R Govoni S T | 2000 | Journal of Pulp and Paper Science2000，26，3： | 1 |
| 20 | The physiology of digestion in fish larvae显示文摘 | Govoni J J Boehlert G W Watanabe Y W | 1986 | Environ Biol Fishes1986，16，： | 1 |
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