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| 1 | Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease显示文摘AIM To determine if manipulation of dietary advanced glycation end product(AGE), intake affects nonalcoholic fatty liver disease(NAFLD) progression and whether these effects are mediated via RAGE. METHODS Male C57Bl6 mice were fed a high fat, high fructose, high cholesterol(HFHC) diet for 33 wk and compared with animals on normal chow. A third group were given a HFHC diet that was high in AGEs. Another group was given a HFHC diet that was marinated in vinegar to prevent the formation of AGEs. In a second experiment, RAGE KO animals were fed a HFHC diet or a high AGE HFHC diet and compared with wildtype controls. Hepatic biochemistry, histology, picrosirius red morphometry and hepatic mR NA were determined. RESULTS Long-term consumption of the HFHC diet generated significant steatohepatitis and fibrosis after 33 wk. In this model, hepatic 4-hydroxynonenal content(a marker of chronic oxidative stress), hepatocyte ballooning, picrosirius red staining, α-smooth muscle actin and collagen type 1A gene expression were all significantly increased. Increasing the AGE content of the HFHC diet by baking further increased these markers of liver damage, but this was abrogated by pre-marination in acetic acid. In response to the HFHC diet, RAGE-/-animals developed NASH of similar severity to RAGE+/+ animals but were protected from the additional harmful effects of the high AGE containing diet. Studies in isolated Kupffer cells showed that AGEs increase cell proliferation and oxidative stress, providing a likely mechanism through which these compounds contribute to liver injury. CONCLUSION In the HFHC model of NAFLD, manipulation of dietary AGEs modulates liver injury, inflammation, and liver fibrosis via a RAGE dependent pathway. This suggests that pharmacological and dietary strategies targeting the AGE/RAGE pathway could slow the progression of NAFLD. | Christopher Leung Chandana B Herath Zhiyuan Jia Sof Andrikopoulos Bronwyn E Brown Michael J Davies Leni R Rivera John B Furness Josephine M Forbes Peter W Angus | 2016 | World Journal of Gastroenterology2016，22，35： | 7 |
| 2 | Long-term carbon dioxide fluxes from a very tall tower in a northern forest:flux measurement method,ology显示文摘 | BERGER B W DAVIS K J YI C | 2001 | Atmos Ocean Technol2001，18，： | 1 |
| 3 | The autonomous underwater glider 'Spray' 显示文摘 | Sherman J Davis R E Owens W B | 2001 | IEEE Journal of Oceanic Engineering2001，26，4： | 1 |
| 4 | Laparoscopic dismembered pyeloplasty-the method of choice in the presence of an enlarged renal pelvis and crossing vessels显示文摘 | Turk I A Davis J W Winkelmann B | 2002 | Eur Urol2002，42，： | 1 |
| 5 | Genetics of Parkinsonism:A review显示文摘 | VAUGHAN J R DAVIS M B WOOD N W | 2001 | Annals of Human Genetics2001，65，2： | 1 |
| 6 | Development of a healthy biscuit: an alternative approach to biscuit manufacture 显示文摘 | W J Boobier J S Baker B Davies | 2006 | Nutri J2006，5，： | 1 |
| 7 | Nitrate and ammonium uptake by nitrogen deficient perennial ryegrass and kentucky bluegrass turf显示文摘 | Bowman D C Paul J L Davis W B | 1989 | Horticulture Science1989，114，： | 1 |
| 8 | Tackling antibiotic resistance显示文摘 | Bush K Courvalin P Dantas G Davies J Eisenstein B Huovinen P Jacoby GA Kishony R Kreiswirth BN Kutter E Lerner SA Levy S Lewis K Lomovskaya O Miller JH Mobashery S Piddock LJ Projan S Thomas CM Tomasz A Tulkens PM Walsh TR Watson JD Witkowski J Witte W Wr | | 0，，： | 1 |
| 9 | The autonomous underwater glider 'spray' 显示文摘 | SHERMAN J DAVIS R E OWENS W B | 2001 | IEEE Journal of Oceanic Engineering2001，126，4： | 1 |
| 10 | Angiotensin Ⅱ inhibits rat arterial KATP channels by inhibiting steady-state protein kinase A activity and activationg protein kinase Ce显示文摘 | Davies N W Standen N B | 2001 | J Physiol2001，530，2： | 1 |
| 11 | Thermal diffusivity/ conductivity of doped graphites显示文摘 | Enweani B N Davis J W Haasz A A | 1995 | Journal of Nuclear Materials1995，224，： | 1 |
| 12 | Prediction of building integrated photovohaic cell temperatures显示文摘 | Davis M W Fanney A H Dougherty B P | 2001 | Journal of Solar Energy Egineering Trans ASME2001，123，： | 1 |
| 13 | The effects of the amplitude distribution of equal energy exposures on noise-induced hearingloss:the kurtosi smetric显示文摘 | Hamemik R P Qiu W Davis B | 2003 | J Acouse Soc Am2003，114，1： | 1 |
| 14 | Morphological instability in epitaxially strained dislocation-free solid films显示文摘 | Spencer B J Voorhees P W Davis S H | 1991 | Physical Review Letters1991，67，26： | 1 |
| 15 | The preparation of 1-methyl-1-cyclohexen-6-one from 1-methylcyclohexene and from 1,2-cyclohexanedione显示文摘 | Butz L W Davis B L Gaddis A M | 1947 | Journal of Organic Chemistry1947，12，： | 1 |
| 16 | A conditional sterile mutation eliminates surface components from Arabidopsis pollen and disrupts cell signaling during fertilization显示文摘 | Preuss D Lemieux B Yen G Davis R W | | 0，，06： | 1 |
| 17 | Comparison of laser versus surface-touch registration for image-guided sinus surgery显示文摘 | WOODWORTH B A DAVIS G W SCHLOSSER R J | 2005 | Am J Rhinol2005，19，： | 1 |
| 18 | Diversity and sensitivity of epiphytes to oxides of nitrogen in London 显示文摘 | Davies L Bates J W Bell J N B | 2007 | Environmental Pollution2007，146，1： | 1 |
| 19 | The Suppression of Saturated Nucleate Boiling by Forced Convective Flow 显示文摘 | Bennett D L Davis M W Hertzler B L | 1980 | American Institute of Chemical Engineers1980，76，： | 1 |
| 20 | A model of the effects of realistic job previews 显示文摘 | Fedor D B Buckley M R Davis W D | 1997 | International Journal of Management1997，14，： | 1 |
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