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| 1 | Duhuo Jisheng Decoction inhibits SDF-1-induced inflammation and matrix degradation in human degenerative nucleus pulposus cells in vitro through the CXCR4/NF-KB pathway显示文摘 | Zong-chao LIU Zhen-long WANG Chen-yi HUANG Zhi-jiang FU Yong LIU Zhang-chao WEI Shi-gui LIU Chuan MA Jie-liang SHEN Dayue Darrel DUAN | 2018 | Acta Pharmacologica Sinica2018，39，6： | 29 |
| 2 | The CIC-3 chloride channels in cardiovascular disease显示文摘 | Dayue Darrel DUAN | 2011 | Acta Pharmacologica Sinica2011，32，6： | 26 |
| 3 | Iron and non-alcoholic fatty liver disease显示文摘The mechanisms that promote liver injury in non-alcoholic fatty liver disease(NAFLD) are yet to be thoroughly elucidated. As such, effective treatment strategies are lacking and novel therapeutic targets are required. Iron has been widely implicated in the pathogenesis of NAFLD and represents a potential target for treatment. Relationships between serum ferritin concentration and NAFLD are noted in a majority of studies, although serum ferritin is an imprecise measure of iron loading. Numerous mechanisms for a pathogenic role of hepatic iron in NAFLD have been demonstrated in animal and cell culture models. However, the human data linking hepatic iron to liver injury in NAFLD is less clear, with seemingly conflicting evidence, supporting either an effect of iron in hepatocytes or within reticulo-endothelial cells. Adipose tissue has emerged as a key site at which iron may have a pathogenic role in NAFLD. Evidence for this comes indirectly from studies that have evaluated the role of adipose tissue iron with respect to insulin resistance. Adding further complexity, multiple strands of evidence support an effect of NAFLD itself on iron metabolism. In this review, we summarise the human and basic science data that has evaluated the role of iron in NAFLD pathogenesis. | Laurence J Britton V Nathan Subramaniam Darrell HG Crawford | 2016 | World Journal of Gastroenterology2016，22，36： | 14 |
| 4 | LA-ICPMS原位微区面扫描分析技术及其矿床学应用实例显示文摘LA-ICPMS原位微区面扫描技术的发展对解析具有包裹体、环带结构的矿物或受多期岩浆/热液活动影响形成的溶蚀再结晶的矿物具有重要的地质意义。黄铁矿作为最普遍的硫化物种类之一,可形成于各种类型矿床中,其微量元素组份记录了矿床形成过程的重要信息。通过LA-ICPMS原位微区面扫描技术获得的黄铁矿晶体内部结构组份信息可用来限定成矿流体的性质、厘定成矿流体的演化规律、示踪成矿物质来源、约束变形变质作用过程中元素的活化和迁移行为,以及约束矿床成因等。本次研究选取了内蒙古二连盆地中巴彦乌拉大型铀矿床、辽宁青城子地区榛子沟铅锌矿、加拿大Pardo砂金矿中的黄铁矿作为研究对象,运用原位微区LA-ICPMS元素面扫描技术揭示其内部组份及结构信息,探索该技术在不同类型矿床中的应用价值。巴彦乌拉大型砂岩型铀矿床中的黄铁矿的内部组构信息显示成矿体系的p H和Eh对硫酸盐还原细菌活动均有影响,并控制与之相关的铀矿化;且成矿体系的p H和Eh受到外界不断供给的地下水的影响,呈振荡性变化。辽宁榛子沟铅锌矿中的黄铁矿的内部组构信息显示矿化过程受到了至少两期流体活动的叠加影响,包括早期同沉积时期的流体以及晚期与燕山期岩浆活动有关的热液流体。加拿大Pardo金矿中黄铁矿的内部组构信息显示矿床中半自形-自形的黄铁矿实际包含碎屑成因的磨圆状核部及后期热液活动形成的增生边;金主要呈浸染状分布在碎屑成因的黄铁矿核部,后期热液活动对金矿化影响微弱。 | 周伶俐 曾庆栋 孙国涛 段晓侠 BONNETTI Christophe RIEGLER Thomas LONG Darrel GF KAMBER Balz | 2019 | 岩石学报2019，35，7： | 13 |
| 5 | Fangjiomics: revealing adaptive omics pharmacological mechanisms of the myriad combination therapies to achieve personalized medicine显示文摘 | Dayue Darrel DUAN Zhong WANG Bo-li ZHANG Yong-yan WANG | 2015 | Acta Pharmacologica Sinica2015，36，6： | 11 |
| 6 | 药物表型组学:药理毒理学和个体化医学的新模式(英文)显示文摘近年来,药物基因组学(pharmacogenomics)研究收集了大量有关遗传多态性对药物反应(疗效和毒性反应)的普遍影响的信息,并突出显示了基因组指导下的个体化药物治疗的必要性。然而,由于疾病和药物治疗临床效果和毒性反应的内在复杂性,并且往往涉及数十个或数百个基因和环境因素的动态变化的影响,将药物基因组学的知识转化为个体化医学的临床实践面临着重大的挑战和障碍。为了克服这些障碍,些包括药物蛋白质组学(pharmacoproteomics)和药物代谢组学(pharmacometabolomics)等在内的新学科应运而生。同时,这些'组学'研究也揭示了在越来越详细的基因组/蛋白质组学/代谢组学的变异性与目前定义的各种临床疾病和药物治疗表型的复杂性之间存在着种非平行关系。因而要种新的研究模式来重新定义这种表型与基因组/蛋白质组/代谢组之间的非平行关系。此文将介绍个跨领域的新学科,它能为从只注重于单纯的表型-基因型关系的研究模式转化到系统性的表型组-基因组关系的研究方法提供整套新的技术平台,从而在系统生物学水平重新定义具有整合性的药物治疗靶点群,改进药物研究的模式,使其更适合于临床个体化医学与药物治疗。这个新学科就是'药物表型组学(pharmacophenomics)'。表型组(phenome)是在特定环境影响下有机体基因组/蛋白质组/代谢组表达的整体表型特征的总和。表型组学(phenomics)则是对表型组与基因组/转录组(transcritome)/蛋白质组/代谢组/相互作用组(interactome)和环境因素变化之间的复杂关系的定量研究。药物表型组学将系统性地确定对应于定义明确的疾病表型组的综合性药物靶标群。因此,药物表型组学将与药物基因组学、药物蛋白质组学组学和药物代谢组学等学科互补,为药物作用和毒性的研究提供个革命性的新模式。 | Dayue Darrel DUAN 韩业山 李立 赵建中 王忠 | 2014 | 中国药理学与毒理学杂志2014，28，1： | 10 |
| 7 | Tumor exosomes: a double-edged sword in cancer therapy显示文摘肿瘤房间比正常房间生产并且藏匿更多的 nucleic 酸,蛋白质和类脂化合物。这些分子在包含膜的 exosomes 在血或在房间附近被搬运。导出肿瘤或联系肿瘤的 exosomes (通常在直径的 30-100 nm ) 包含与为涉及癌症的致病,发展,前进,和转移的细胞间的通讯表明送信人一起父母房间类似于那些的丰富的生物内容。当这些 exosomes 能从各种各样的身体液体被检测并且孤立,他们为癌症的诊断和预后成为了吸引人的新 biomarkers。而且,肿瘤 exosomes 也为癌症的治疗由于他们的潜在的同样新奇的治疗学的策略吸引了增加的注意。在一方面,包含膜的泡正在答应药和指向特定的癌症房间的另外的治疗学的材料的搬运人的类脂化合物 bilayer。在另一方面,肿瘤 exosomes 是为象 chemoresistance 一样安排对癌症房间的生长和转移批评的事件的微型环境的调整的重要调停人。这里,我们在最近的年里在我们联系肿瘤或导出肿瘤的 exosomes 的理解总结进展,并且更重要地在癌症的癌症开发,前进,侵略,和转移并且,讨论他们的角色,他们在为各种各样的癌症以及重要警告的精确治疗的策略的潜力。 | Wei SUN Ju-dong LUO Hua JIANG Dayue Darrel DUAN | 2018 | Acta Pharmacologica Sinica2018，39，4： | 9 |
| 8 | Characterization of a critical role for CFTR chloride channels in cardioprotection against ischemia/ reperfusion injury显示文摘目的: 进一步描绘膀胱的纤维变性 transmembrane 传导力管理者(CFTR ) 的功能的角色在早、迟了(第二扇窗户) ischemic preconditioning (欧洲电脑生产厂商)- 并且 postconditioning (停靠港) 调停了对 ischemia/reperfusion (I/R ) 的 cardioprotection 损害。 | Sunny Yang XIANG Linda L YE Li-lu Marie DUAN Li-hui LIU Zhi-dong GE John A AUCHAMPACH Garrett J GROSS Dayue Darrel DUAN | 2011 | Acta Pharmacologica Sinica2011，32，6： | 9 |
| 9 | Chrysophanol protects against doxorubicin-induced cardiotoxicity by suppressing cellular PARylation显示文摘The clinical application of doxorubicin(DOX) in cancer chemotherapy is limited by its lifethreatening cardiotoxic effects. Chrysophanol(CHR), an anthraquinone compound isolated from the rhizome of Rheum palmatum L., is considered to play a broad role in a variety of biological processes.However, the effects of CHR’s cardioprotection in DOX-induced cardiomyopathy is poorly understood. In this study, we found that the cardiac apoptosis, mitochondrial injury and cellular PARylation levels were significantly increased in H9 C2 cells treated by Dox, while these effects were suppressed by CHR. Similar results were observed when PARP1 activity was suppressed by its inhibitors 3-aminobenzamide(3 AB)and ABT888. Ectopic expression of PARP1 effectively blocked this CHR’s cardioprotection against DOX-induced cardiomyocyte injury in H9 C2 cells. Furthermore, pre-administration with both CHR and 3 AB relieved DOX-induced cardiac apoptosis, mitochondrial impairment and heart dysfunction in Sprague–Dawley rat model. These results revealed that CHR protects against DOX-induced cardiotoxicity by suppressing cellular PARylation and provided critical evidence that PARylation may be a novel target for DOX-induced cardiomyopathy. | Jing Lu Jingyan Li Yuehuai Hu Zhen Guo Duanping Sun Panxia Wang Kaiteng Guo Dayue Darrel Duan Si Gao Jianmin Jiang Junjian Wang Peiqing Liu | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 8 |
| 10 | Interleukin-7 Receptor Signaling Network:An Integrated Systems Perspective显示文摘Interleukin-7 (IL-7) is an essential cytokine for the development and homeostatic maintenance of T and B lymphocytes. Binding of IL-7 to its cognate receptor,the IL-7 receptor (IL-7R),activates multiple pathways that regulate lymphocyte survival,glucose uptake,proliferation and differentiation. There has been much interest in understanding how IL-7 receptor signaling is modulated at multiple interconnected network levels. This review examines how the strength of the signal through the IL-7 receptor is modulated in T and B cells,including the use of shared receptor components,signaling crosstalk,shared interaction domains,feedback loops,integrated gene regulation,multimerization and ligand competition. We discuss how these network control mechanisms could integrate to govern the properties of IL-7R signaling in lymphocytes in health and disease. Analysis of IL-7 receptor signaling at a network level in a systematic manner will allow for a comprehensive approach to understanding the impact of multiple signaling pathways on lymphocyte biology. | Megan J. Palmer Vinay S. Mahajan Lily C. Trajman Darrell J. Irvine Douglas A.Lauffenburger Jianzhu Chen | 2008 | Cellular & Molecular Immunology2008，5，2： | 8 |
| 11 | Chloride channels in stroke显示文摘脉管包括脉管的光滑的肌肉房间(VSMC ) 的增长,移植,和 apoptosis,服的小动脉改变在大脑是在动脉和血流动或出血的突然的打断的代表性的区域和直径的变化的主要原因,即,中风。积累的证据强烈为氯化物支持一个重要角色(在脉管的改变和击的 Cl −) 隧道。至少三 Cl − 隧道基因在 VSMC 被表示:1 ) TMEM16A (或 Ano1 ) ,它可以编码激活钙的 Cl − 隧道(CACC ) ;2 ) CLC-3 Cl − 隧道和 Cl −/H+ antiporter,它是仔细与调整卷的 Cl − 隧道(VRCC ) 有关;并且 3 ) 膀胱的纤维变性 transmembrane 传导力管理者(CFTR ) 它编码激活 PKA 、激活 PKC 的 Cl − 隧道。由细胞内部的 Ca 2+ 的导致收缩筋的增加的 CACC 的激活引起 VSMC 的膜去极,血管缩小,和抑制增长。由房间体积增加或膜段的 VRCC 的激活支持反应的氧种类的生产,导致增长并且禁止 VSMC 的 apoptosis。CFTR 的激活禁止氧化应力并且可以阻止高血压的发展。另外, Cl − 电流由 gamma-aminobutyric 酸(伽马氨基丁酸) 调停了受体也被含有在 ischemic 神经原死亡的一个角色。这评论在中风的发展集中于 Cl − 隧道的功能的角色并且在未来方向上提供一个观点让研究和潜力为中风的预防和治疗作为新目标开发 Cl − 隧道。 | Ya-ping ZHANG Hao ZHANG Dayue Darrel DUAN | 2013 | Acta Pharmacologica Sinica2013，34，1： | 8 |
| 12 | New frontiers for the materials genome initiative显示文摘The Materials Genome Initiative(MGI)advanced a new paradigm for materials discovery and design,namely that the pace of new materials deployment could be accelerated through complementary efforts in theory,computation,and experiment.Along with numerous successes,new challenges are inviting researchers to refocus the efforts and approaches that were originally inspired by the MGI.In May 2017,the National Science Foundation sponsored the workshop“Advancing and Accelerating Materials Innovation Through the Synergistic Interaction among Computation,Experiment,and Theory:Opening New Frontiers”to review accomplishments that emerged from investments in science and infrastructure under the MGI,identify scientific opportunities in this new environment,examine how to effectively utilize new materials innovation infrastructure,and discuss challenges in achieving accelerated materials research through the seamless integration of experiment,computation,and theory.This article summarizes key findings from the workshop and provides perspectives that aim to guide the direction of future materials research and its translation into societal impacts. | Juan J.de Pablo Nicholas E.Jackson Michael A.Webb Long-Qing Chen Joel E.Moore Dane Morgan Ryan Jacobs Tresa Pollock Darrell G.Schlom Eric S.Toberer James Analytis Ismaila Dabo Dean M.DeLongchamp Gregory A.Fiete Gregory M.Grason Geoffroy Hautier Yifei Mo Krishna Rajan Evan J.Reed Efrain Rodriguez Vladan Stevanovic Jin Suntivich Katsuyo Thornton Ji-Cheng Zhao | 2019 | npj Computational Materials2019，，1： | 7 |
| 13 | Humanin attenuates Alzheimer-like cognitive deficits and pathological changes induced by amyloid β-peptide in rats显示文摘Amyloid β-peptide(Aβ) has been implicated as a key molecule in the neurodegenerative cascades of Alzheimer 's disease(AD). Humanin(HN) is a secretory peptide that inhibits the neurotoxicity of Aβ. However, the mechanism(s) by which HN exerts its neuroprotection against Aβ-induced ADlike pathological changes and memory deficits are yet to be completely defined. In the present study,we provided evidence that treatment of rats with HN increases the number of dendritic branches and the density of dendritic spines, and upregulates pre- and post-synaptic protein levels; these effects lead to enhanced long-term potentiation and amelioration of the memory deficits induced by Aβ1-42. HN also attenuated Aβ1-42-induced tau hyperphosphorylation,apparently by inhibiting the phosphorylation of Tyr307 on the inhibitory protein phosphatase-2A(PP2A)catalytic subunit and thereby activating PP2 A. HN also inhibited apoptosis and reduced the oxidativestress induced by Aβ1-42. These findings provide novel mechanisms of action for the ability of HN to protect against Aβ1-42-induced AD-like pathological changes and memory deficits. | Gao-Shang Chai Dong-Xiao Duan Rong-Hong Ma Jian-Ying Shen Hong-Lian Li Zhi-Wei Ma Yu Luo Lu Wang Xin-Hua Qi Qun Wang Jian-Zhi Wang Zelan Wei Darrell D.Mousseau Li Wang Gongping Liu | 2014 | Neuroscience Bulletin2014，30，6： | 7 |
| 14 | 牧草系统的生化它感显示文摘植物次级代谢物及其降解产物对包括牧草在内的所有农业生态系统都有重要影响。生化它感影响耕作制度和一物种进入另一已建植物种的草场。自体毒性和异体毒性都是生化它感的类型。苜蓿是既具自毒又具它毒的物种,收后立即重播苜蓿常因自毒而生长不良。还有几种牧草也具自体毒性,许多牧草则表现与杂草间的异体毒性。业已鉴别出一些起生化它感作用的生化它感物质。这类物质的鉴别有助于培育出抗性的牧草品种和维持其生产力。轮作、作物覆盖、间作、双季作、免耕、非轮作均涉及到生化它感。某些牧草对生化它感物具有一定抗性,可以用作抗性种质。一些牧草和杂草对苜蓿有生化它感效应;而苜蓿对某些杂草有生化它感效应。这可以启示苜蓿生产中的除草剂的研究。 | Darrell A.Miller 白朴 | 1997 | 国外畜牧学(草原与牧草)1997，，4： | 5 |
| 15 | 脑海绵状血管畸形临床诊疗指南概要:血管瘤联盟科学咨询委员会临床专家组基于系统文献评价的共识推荐显示文摘背景尽管脑海绵状血管畸形(cerebral cavernous malformation, CCM)的相关研究文献已相当丰富,但在诊断和治疗策略方面仍存在着争议。目的制订CCM诊疗指南。方法作为代表CCM患者和研究的患者支持团体,血管瘤联盟(www.angioma.org)召集了一个包括CCM临床专家在内的多学科写作组来帮助总结现有的CCM临床诊疗相关文献,重点关注5个主题:(1)流行病学和自然病程;(2)遗传检测和咨询;(3)诊断标准和影像学标准;(4)神经外科注意事项;(5)神经内科注意事项。写作组根据预定方案进行了文献回顾和证据评价,最终制定推荐意见,并且确立了共识、争议和知识空白。结果根据方法学标准从1983年1月1日至2014年9月31日期间公开发表的1 270篇文献中筛选出98篇,并确定了另外38篇近期或相关的文献。各主题作者利用这些文献总结了现有知识并形成了23项共识诊疗推荐,同时根据美国心脏协会/美国卒中协会标准进行了推荐强度(效应量)和证据水平(确定性估计)评级。其中,尚无A级证据(因为缺乏随机对照试验),B级证据11项(48%),C级证据12项(52%);Ⅰ级推荐8项(35%),Ⅱ级推荐10项(43%),Ⅲ级推荐5项(22%)。结论现有证据支持对CCM诊疗的推荐,但这些证据的级别和推荐强度普遍较低,因此需要进一步研究来帮助进行更好的临床实践并更新这些推荐。完整的推荐文档包括引用文献的纳入标准、关于各项推荐更详尽的评判标准以及各种争议和知识空白的总结,同样通过了同行评议并可在线获取(www.angioma.org/CCMGuidelines)。 | Amy Akers Rustam Al-Shahi Salman Issam A. Awad Kristen Dahlem Kelly Flemming Blaine Hart Helen Kim Ignacio Jusue-Torres Douglas Kondziolka Cornelia Lee Leslie Morrison Daniele Rigamonti Tania Rebeiz Elisabeth Toumier-Lasserve Darrel Waggoner Kevin Whitehead 鄂同舟 雷宇 倪伟 顾宇翔 | 2017 | 国际脑血管病杂志2017，25，7： | 4 |
| 16 | 项目管理知识体系(PMBOK~)指南第三版概述显示文摘项目管理知识体系(PMBOK)指南第三版的发表标志着美国项目管理协会(PMI)在致力于将其项目管理标准演化为更易于使用、内容更为统一完整的进程中迈出的重要一步。本文将简要说明通过《项目管理知识体系指南2004》修订项目组的努力工作所做出的修订内容。修订工作组自2001年2月起开始修订工作, | Dennis Bolles Darrel G.Hubbard 薛岩 | 2004 | 项目管理技术2004，2，12： | 4 |
| 17 | Enhanced Efficiency of Milk Utilization for Growth in Surviving Low-Birth-Weight Piglets显示文摘This study determined effects of birth weights (0.70 to 1.09, 1.10 to 1.49, 1.50 to 1.89, and≥1.90 kg) on the efficiency of milk utilization for growth in sow-reared piglets. One-hundred-sixty piglets from 18 multiparous sows (Landrace×Large White) were individually weighed immediately after birth (day 0) and at 7-day intervals for 35 days. Milk consumption of piglets was determined weekly using the weigh-suckle-weigh method. Deaths of piglets were recorded daily. Piglets with the lightest birth weight had the highest incidence of mortality. Birth weights between 0.70 and 1.89 kg were positively associated with average daily gains (ADG, g/day) during the suckling period (P<0.01). Compared with piglets having birth weights of 1.50 to 1.89 kg, birth weights≥1.90 kg did not confer any additional benefit on preweaning survival or ADG. Colostrum or milk consumption per kilogram of body weight among low-, normal-, and large-birth-weight piglets did not differ in the first week. At days 14 to 35, milk consumption of piglets (g/kg BW/day) increased (P<0.01) but the ratio of gain to milk consumption decreased (P<0.01) progressively, as their birth weights increased from 0.70 to ≥1.90 kg. Additionally, surviving low-birth-weight piglets had a higher relative growth rate (%/day) than normal-and large-birth-weight piglets. Based on these novel findings, it is imperative that great efforts be made to improve the survival of low-birth-weight piglets so as to increase the efficiency of nutrient utilization by both lactating sows and suckling piglets. | Reza Rezaei Darrell A. Knabe Xilong Li Shuo Feng Guoyao Wu | 2011 | Journal of Animal Science and Biotechnology2011，2，2： | 4 |
| 18 | New omic and network paradigms for deep understanding of therapeutic mechanisms for Fangji of traditional Chinese medicine显示文摘 | Dayue Darrel DUAN Zhong WANG Yong-yan WANG | 2018 | Acta Pharmacologica Sinica2018，39，6： | 4 |
| 19 | Risk of Cerebrovascular Accidents and Ischemic Heart Disease in Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-analysis显示文摘 | Siddharth Singh Harkirat Singh Edward V. Loftus Darrell S. Pardi | 2014 | Clinical Gastroenterology and Hepatology2014，，3： | 3 |
| 20 | Biologics:how far can they go in Crohn’s disease?显示文摘Crohn’s disease is a chronic gastrointestinal inflammatory disorder,characterized by episodes of relapsing and remitting flares.As the disease mechanism becomes better elucidated,there is a significant increase in the number of available biologic therapies.This article summarizes and synthesizes current Food and Drug Administration-approved biological therapy for Crohn’s disease and examines the positioning of medical therapy as emerging biologics break onto the market. | Katie A.Dunleavy Darrell S.Pardi | 2022 | Gastroenterology Report2022，10，1： | 3 |
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