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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | 电针减少大鼠神经元缺血性损伤并增强碱性成纤维生长因子的表达显示文摘采用线栓法MCAO缺血动物模型 ,观察了不同时程电针对局灶性脑缺血大鼠脑梗死、脑肿胀、纹状体 ,皮层神经元数量的影响 ,同时观察了缺血再灌注和电针对碱性成纤维生长因子 (bFGF)免疫活性在纹状体梗死周边区和额顶叶皮质表达的影响。结果表明 :在中动脉阻塞引起的脑缺血后 ,可见受损脑侧有明显的脑梗死 ,脑肿胀 ,神经元丢失 ,并伴随有显著的bFGF免疫活性物质表达增加。在纹状体梗死周边区 ,bFGF免疫活性物质主要位于星型胶质细胞 ,但在紧临梗塞的区域 ,一些神经元中也有bFGF表达。在额顶叶皮质 ,神经元中有非常显著的bFGF免疫活性增加。对于减少脑梗塞和脑肿胀 ,无论是缺血或再灌期间电针均能取得显著性效果 ,并且 ,对于减少脑肿胀 ,再灌期间电针作用可能较强。缺血再灌后 ,在纹状体梗死周边区和额顶叶皮质bFGF免疫活性表达增加。缺血或再灌期间电针均能进一步上调bFGF免疫活性表达。结果提示 ,在纹状体 ,胶质细胞可能通过表达bFGF起到神经保护作用 ;在额顶叶皮质 ,神经元可能主要通过分泌bFGF而实现自我保护。电针的神经保护效应可能部分通过增强内源性bFGF表达实现。 | 欧阳伟 HUANG YL DA CD | 2000 | 山西医科大学学报2000，，z1： | 9 |
| 3 | Imaging of craniofaeial fibrous dysplasia显示文摘 | Lisle DA Monsour PA Maskiell CD | 2008 | J Med Imaging Radiat Oncol2008，52，4： | 1 |
| 4 | D-dimers in the diagnosis of pul- monary embolism显示文摘 | Quinn DA Fogel FB Smith CD | 1999 | Am J Respir Crit Care Med1999，159，： | 1 |
| 5 | Zebrafish neurotransmitter systems as potential pharmacological and toxico logical targets显示文摘 | Rico EP Rosemberg DB Seibt KJ Capiotti KM Da Silva RS Bonan CD | 2011 | Neurotoxicol Teratol2011，33，6： | 1 |
| 6 | MDM2 protein expression is a negative prognostic marker in breast carcinoma 显示文摘 | Turbin DA Cheang MC Bajdik CD | 2006 | Mod- Patho2006，19，1： | 1 |
| 7 | An antagonist of integrinav^3 prevents maturation of blood vessels during embiyonic neovascular-ization显示文摘 | Urake CJ Cheresh DA Little CD | 1995 | J Cell Sci1995，108，7： | 1 |
| 8 | Alteration of basic fi- broblast growth factor expression in rat during cerebral isch- emia显示文摘 | Wei OY Huang YL Da CD | 2000 | Acta Pharmacol Sin2000，21，4： | 1 |
| 9 | Schlafen, a flew family of growth regulatory genes that affect thymocyte development 显示文摘 | Schwarz DA Katayama CD Hedrick SM | 1998 | Immunity1998，9，5： | 1 |
| 10 | Inhibition by nitrioxide and nitricoxide-producing rasculators of DNA systhesis in vascular smooth muscle eell显示文摘 | Parks DA Strasser A Gregorv CD | 1983 | Surgery1983，94，： | 1 |
| 11 | D- dimer in the diagnosis of pulmonary embolism显示文摘 | Quinn DA Fogel RB Smith CD | 1999 | Am J Respir Crit Care Med1999，159，： | 1 |
| 12 | Adenoma detection rate and risk of colorectal cancer and death显示文摘 | Corley DA Jensen CD Marks AR | 2014 | N Engl J Med2014，370，14： | 1 |
| 13 | Influence of acupuncture upon expressing levels of basic fibroblast growth factor in rat brain following focal cerebral ischemia-evaluated by time-resolved fluorescence immunoassay显示文摘 | Ou YW Han L Da CD | 2001 | Neurol Res2001，23，1： | 1 |
| 14 | A comparison ofaprotinin and lysine analogues in high-risk cardiac surgery显示文摘 | Fergusson DA Hebert PC Mazer CD | 2008 | N Engl J Med2008，358，22： | 1 |
| 15 | Whole - body CT screening: spectrum of findings and recommendations in 1192 pa- tients显示文摘 | Furtado CD Aguirre DA Sirlin CB | 2005 | Radiology2005，237，： | 1 |
| 16 | Differences beween syncope resulting from rapid onset acceleration and orthostaic stress显示文摘 | Self DA White CD Shaffstall RM | 1996 | Aviat Space Environ Med1996，67，6： | 1 |
| 17 | A comparison of aprotinin and lysine analogues in high-risk cardiac surgery显示文摘 | Fergusson DA Hebert PC Mazer CD | 2008 | N Engl J Med2008，358，22： | 1 |
| 18 | Alteration of basic fibroblast growth factor expression in rat during cerebral ischemia显示文摘 | Wei OY Huang YL Da CD | 2000 | Acta Pharmacol Sin2000，21，4： | 1 |
| 19 | In vitro and in vivo inhibition of skin matrix metalloproteinases by Pothomorphe umbellata root extract显示文摘 | Ropke CD da Silva VV Kera CZ | 2006 | Photochem Photobiol2006，82，2： | 1 |
| 20 | Reduction of infarct size and preservation of endothelial function by multidose intravenous adenosine during extended reperfusion显示文摘 | MORRIS CD VELEZ DA | 2004 | J Surg Res2004，116，1： | 1 |
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