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| 1 | 英国输血过程的国家审查显示文摘为改进输血工作质量和文件记录,英国皇家医师协会疗效评审部(CEEU)与英国血液学会、英国输血协会以及美国皇家病理学协会,根据英国皇家医师协会1995年的资料汇编,共同制定了9项审查方案。 1995年9月,国家卫生部(NHSE)资助了国家审查从两项审查方案开始。一项是对机构的输血工作审查,另一项是对输血的记录审查。虽然根据英国血液标准委员会(BCSH)关于医院输血记录指南,审查方案有了不明确的标准,但在此项目开展以前,并没有制定明确的标准。该项研究的目的是收集基本数据,以便制定严格有效的输血治疗标准和制定一个全国性的输血治疗审查质量的检测方法,修订全国的输血指南。 | M.F.Murphy J.Wilkinson D.Lowe etal 李执如 孙启凤 季阳 | 2003 | 国外医学(输血及血液学分册)2003，26，4： | 1 |
| 2 | Probing the architecture of the Mycobacterium marinum arylamine N-acetyltransferase active site显示文摘Treatment of latent tuberculosis infection remains an important goal of global TB eradication.To this end,targets that are essential for intracellular survival of Mycobacterium tuberculosis are particularly attractive.Arylamine N-acetyltransferase(NAT)represents such a target as it is,along with the enzymes encoded by the associated gene cluster,essential for mycobacterial survival inside macrophages and involved in cholesterol degradation.Cholesterol is likely to be the fuel for M.tuberculosis inside macrophages.Deleting the nat gene and inhibiting the NAT enzyme prevents survival of the microorganism in macrophages and induces cell wall alterations,rendering the mycobacterium sensitive to antibiotics to which it is normally resistant.To date,NAT from M.marinum(MMNAT)is considered the best available model for NAT from M.tuberculosis(TBNAT).The enzyme catalyses the acetylation and propionylation of arylamines and hydrazines.Hydralazine is a good acetyl and propionyl acceptor for both MMNAT and TBNAT.The MMNAT structure has been solved to 2.1Åresolution following crystallisation in the presence of hydralazine and is compared to available NAT structures.From the mode of ligand binding,features of the binding pocket can be identified,which point to a novel mechanism for the acetylation reaction that results in a 3-methyltriazolo[3,4-a]phthalazine ring compound as product. | Areej M.Abuhammad Edward D.Lowe Elizabeth Fullam Martin Noble Elspeth F.Garman Edith Sim | 2010 | Protein & Cell2010，1，4： | 1 |
| 3 | Integrating the Climate Science Modelling Language with geospatial software and services显示文摘Much consideration is rightly given to the design of metadata models to describe data.At the other end of the data-delivery spectrum much thought has also been given to the design of geospatial delivery interfaces such as the Open Geospatial Consortium standards,Web Coverage Service(WCS),Web Map Server and Web Feature Service(WFS).Our recent experience with the Climate Science Modelling Language shows that an implementation gap exists where many challenges remain unsolved.To bridge this gap requires transposing information and data from one world view of geospatial climate data to another.Some of the issues include:the loss of information in mapping to a common information model,the need to create‘views’onto file-based storage,and the need to map onto an appropriate delivery interface(as with the choice between WFS and WCS for feature types with coverage-valued properties).Here we summarise the approaches we have taken in facing up to these problems. | D.Lowe A.Woolf B.Lawrence S.Pascoe | 2009 | International Journal of Digital Earth2009，2，S01： | 0 |
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