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| 1 | Increased virulence of the oral microbiome in oral squamous cell carcinoma revealed by metatranscriptome analyses显示文摘Oral squamous cell carcinoma(OSCC) is the most prevalent and most commonly studied oral cancer. However, there is a void regarding the role that the oral microbiome may play in OSCC. Although the relationship between microbial community composition and OSCC has been thoroughly investigated, microbial profiles of the human microbiome in cancer are understudied. Here we performed a small pilot study of community-wide metatranscriptome analysis to profile mRNA expression in the entire oral microbiome in OSCC to reveal molecular functions associated with this disease. Fusobacteria showed a statistically significantly higher number of transcripts at tumour sites and tumour-adjacent sites of cancer patients compared to the healthy controls analysed. Regardless of the community composition, specific metabolic signatures were consistently found in disease. Activities such as iron ion transport, tryptophanase activity, peptidase activities and superoxide dismutase were over-represented in tumour and tumour-adjacent samples when compared to the healthy controls. The expression of putative virulence factors in the oral communities associated with OSCC showed that activities related to capsule biosynthesis, flagellum synthesis and assembly, chemotaxis, iron transport, haemolysins and adhesins were upregulated at tumour sites. Moreover, activities associated with protection against reactive nitrogen intermediates, chemotaxis, flagellar and capsule biosynthesis were also upregulated in non-tumour sites of cancer patients. Although they are preliminary, our results further suggest that Fusobacteria may be the leading phylogenetic group responsible for the increase in expression of virulence factors in the oral microbiome of OSCC patients. | Susan Yost Philip Stashenko Yoonhee Choi Maria Kukuruzinska Caroline A.Genco Andrew Salama Ellen O.Weinberg Carolyn D.Kramer Jorge Frias-Lopez | 2018 | International Journal of Oral Science2018，10，4： | 9 |
| 2 | P3: An installation for high-energy density plasma physics and ultra-high intensity laserematter interaction at ELI-Beamlines显示文摘ELI-Beamlines(ELI-BL),one of the three pillars of the Extreme Light Infrastructure endeavour,will be in a unique position to perform research in high-energy-density-physics(HEDP),plasma physics and ultra-high intensity(UHI)ð>10^(22) W=cm^(2)) lasereplasma interaction.Recently the need for HED laboratory physics was identified and the P3(plasma physics platform)installation under construction in ELI-BL will be an answer.The ELI-BL 10 PW laser makes possible fundamental research topics from high-field physics to new extreme states of matter such as radiation-dominated ones,high-pressure quantum ones,warm dense matter(WDM)and ultra-relativistic plasmas.HEDP is of fundamental importance for research in the field of laboratory astrophysics and inertial confinement fusion(ICF).Reaching such extreme states of matter now and in the future will depend on the use of plasma optics for amplifying and focusing laser pulses.This article will present the relevant technological infrastructure being built in ELI-BL for HEDP and UHI,and gives a brief overview of some research under way in the field of UHI,laboratory astrophysics,ICF,WDM,and plasma optics. | S.Weber S.Bechet S.Borneis L.Brabec M.Bucka E.Chacon-Golcher M.Ciappina M.DeMarco A.Fajstavr K.Falk E.-R.Garcia J.Grosz Y.-J.Gu J.-C.Hernandez M.Holec P.Janecka M.Jantac M.Jirka H.Kadlecova D.Khikhlukha O.Klimo G.Korn D.Kramer D.Kumar T.Lastovicka P.Lutoslawski L.Morejon V.Olsovcova M.Rajdl O.Renner B.Rus S.Singh M.Smid M.Sokol R.Versaci R.Vrana M.Vranic J.Vyskocil A.Wolf Q.Yu | 2017 | Matter and Radiation at Extremes2017，2，4： | 8 |
| 3 | Immunohistochemical and molecular characterization of cultured keratinocytes after dispase‐mediated detachment from the growth substratum显示文摘 | B. M.Schaefer R.Wallich K.Schmolke W.Fink M.Bechtel J.Reinartz M. D.Kramer | 2001 | Experimental Dermatology2001，，1： | 1 |
| 4 | The L4n laser beamline of the P3-installation:Towards high-repetition rate high-energy density physics at ELI-Beamlines显示文摘The P3 installation of ELI-Beamlines is conceived as an experimental platform for multiple high-repetition-rate laser beams spanning time scales from femtosecond via picosecond to nanosecond.The upcoming L4n laser beamline will provide shaped nanosecond pulses of up to 1.9 kJ at a maximum repetition rate of 1 shot/min.This beamline will provide unique possibilities for high-pressure,high-energy-density physics,warm dense matter,and laser–plasma interaction experiments.Owing to the high repetition rate,it will become possible to obtain considerable improvements in data statistics,in particular,for equation-of-state data sets.The nanosecond beam will be coupled with short sub-picosecond pulses,providing high-resolution diagnostic tools by either irradiating a backlighter target or driving a betatron setup to generate energetic electrons and hard X-rays. | N.Jourdain U.Chaulagain M.Havlik D.Kramer D.Kumar V.T.Tikhonchuk G.Korn S.Weber | 2021 | Matter and Radiation at Extremes2021，6，1： | 0 |
| 5 | 美国的蚊虫防治与机遇显示文摘 | Mr.Richard D.Kramer 程心智 | 2003 | 中华卫生杀虫药械2003，9，2： | 0 |
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