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| 1 | 5-ASA colonic mucosal concentrations resulting from different pharmaceutical formulations in ulcerative colitis显示文摘AIM:To compare the mucosal concentrations of 5-aminosalicylic acid(5-ASA)resulting from different pharmaceutical formulations and analyse the influence of inflammation on the mucosal concentrations.METHODS:The study included 130 inflammatory bowel disease(IBD)patients receiving 5-ASA as pH-dependent-release formulations(73 patients),time-dependent-release formulations(11 patients),or pro-drugs(18patients).In addition,28 patients were receiving topical treatment(2-4 g/d)with pH-dependent-release formulations.Endoscopic biopsies were obtained from the sigmoid region during the colonoscopy.The 5-ASA concentrations(ng/mg)were measured in tissue homogenatesusing high-pressure liquid chromatography with electrochemical detection.The t test and Mann-Whitney test,when appropriate,were used for statistical analysis.RESULTS:Patients receiving pH-dependent-release formulations showed significantly higher mucosal concentrations of 5-ASA(51.75±5.72 ng/mg)compared with patients receiving pro-drugs(33.35±5.78 ng/mg,P=0.01)or time-dependent-release formulations(38.24±5.53 ng/mg,P=0.04).Patients with endoscopic remission had significantly higher mucosal concentrations of5-ASA than patients with active disease(60.14±7.95ng/mg vs 35.66±5.68 ng/mg,P=0.02).Similar results were obtained when we compared patients with the histological appearance of remission and patients with active histological inflammation(67.53±9.22 ng/mg vs 35.53±5.63 ng/mg,P<0.001).Significantly higher mucosal concentrations of 5-ASA were detected in patients treated with both oral and topical treatments in combination compared with patients who received oral treatment with pH-dependent-release formulations alone(72.33±11.23 ng/mg vs 51.75±5.72 ng/mg,P=0.03).CONCLUSION:IBD patients showed significant variability in mucosal 5-ASA concentrations depending on the type of formulation,and the highest mean concentration was achieved using pH-dependent-release formulations. | Renata D’Incà Martina Paccagnella Romilda Cardin Surajit Pathak Vincenzo Baldo Maria Cecilia Giron Giacomo Carlo Sturniolo | 2013 | World Journal of Gastroenterology2013，19，34： | 4 |
| 2 | Solute clearances during continuous venovenous heamofiltration at various ultrafiltration flow rates using multiflow-100 and HF1000 filters 显示文摘 | Troyanov S Cardinal J Geadah D | 2003 | Nephrol Dial Transplant2003，18，： | 2 |
| 3 | The use of knowledge for technological innovation within diversified firms显示文摘 | Miller D J Fern M J Cardinal L B | 2007 | Academy of Management Journal2007，50，2： | 1 |
| 4 | Serial Surgical Debridement:a Retrospective Study on Clinical Outcomes in Chronic Lower Extremity Wounds显示文摘 | Cardinal M Eisenbud D E Armstrong D G | 2009 | Wound Repair Regen2009，17，3： | 1 |
| 5 | Ultrasonic Doppler Velocimetry in Liquid Gallium 显示文摘 | Brito D Natal H C Cardin P | 2001 | Experiments in Fluids2001，31，6： | 1 |
| 6 | The use of knowledge fortechnological innovation within diversified firms 显示文摘 | Miller D J Fern M J Cardinal L B | 2007 | Academy ofManagement Journal2007，50，2： | 1 |
| 7 | Structuring research and development teams in the technological conversion process显示文摘 | Cardinal L B Lei D Beyerlein M M | 2000 | Team Performance Management2000，6，3： | 1 |
| 8 | Study of the microbial ecology of cold-smoked salmon during storage at 8°C显示文摘 | Fran?oise Leroi Jean-Jacques Joffraud Frédérique Chevalier Mireille Cardinal | 1998 | International Journal of Food Microbiology1998，，1： | 1 |
| 9 | Evolution of the atrial fibrillation substrate in experimental congestive heart failure : angiotensin-dependent and-independent pathways 显示文摘 | Cardin S Li D Thorin-Trescases N | 2003 | Cardiovasc Res2003，60，： | 1 |
| 10 | Three-dimensional ultrasound imaging 显示文摘 | Fenster A Downey D B Cardinal H N | 2001 | Phys Med Biol2001，46，5： | 1 |
| 11 | Three-dimensional ultrasound imaging显示文摘 | FENSTER A DOWNEY D B CARDINAL H N | 2001 | Phys Med Biol2001，46，5： | 1 |
| 12 | Evolution of the atrial fibrillation substrate in experimental congestive heart failure: Angiotensin-dependent and -independent pathways显示文摘 | Cardin S Li D Thorin-Trescases N | 2003 | Cardiovasc Res2003，60，： | 1 |
| 13 | The use of knowledge for technological innovation within diversified firms显示文摘 | Miller D J Fern M J Cardinal L B | 2007 | The Academy of Management Journal2007，50，2： | 1 |
| 14 | The use of knowledge for technological innovation within diversified firms 显示文摘 | Miller D J Fern M J Cardinal L B | 2007 | Academy of Management Journal2007，50，2： | 1 |
| 15 | Determination of refractive index, thickness, and the optical losses of thin films from prism-film coupling measurements 显示文摘 | Cardin J Leduc D | 2008 | Appl Opt2008，47，7： | 1 |
| 16 | Silicon isotopic fraetionafion during adsorption of aqueous monosilicie acid onto iron oxide显示文摘 | S Delstanche S Opfergelt D Cardinal | 2009 | Geochimica et Cosmochimica Acta2009，73，： | 1 |
| 17 | Three-dimensional ultrasound imaging显示文摘 | Fenster A Downey D B Cardinal H N | 2001 | Physics in Medicine and Biology2001，46，5： | 1 |
| 18 | Evolution of the atrial fibrillation substrate in experimental congestive heart failure: angiotensin-dependent and -independent pathways显示文摘 | Cardin S Li D Thorin-Trescases N | 2003 | Cardiovasc Res2003，60，： | 1 |
| 19 | Evolution of the atrial fibrillation substrate in experimental congestive heart tailure; angiotensin-de- pendent and indpendent pathways 显示文摘 | Cardin S Li D Thorn TN | 2003 | Cardiovasc Res2003，60，2： | 1 |
| 20 | The Use of Knowledge for Technological Innovation with- in Diversified Firms 显示文摘 | kMILLER D J FERN M J CARDINAL L B | 2007 | Academy of Management Journal2007，50，2： | 1 |
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