|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Allele-aware chromosome-level genome assembly of Artemisia annua reveals the correlation between ADS expansion and artemisinin yield显示文摘Artemisia annua is the major natural source of artemisinin,an anti-malarial medicine commonly used worldwide.Here,we present chromosome-level haploid maps for two A.annua strains with different artemisinin contents to explore the relationships between genomic organization and artemisinin production.High-fidelity sequencing,optical mapping,and chromatin conformation capture sequencing were used to assemble the heterogeneous and repetitive genome and resolve the haplotypes of A.annua.Approximately 5o,ooo genes were annotated for each haplotype genome,and a triplication event that occurred approximately 58.12million years ago was examined for the first time in this species.A total of 3,903,467-5,193,414 variants(SNPs,indels,and structural variants)were identified in the 1.5-Gb genome during pairwise comparison between haplotypes,consistent with the high heterozygosity of this species.Genomic analyses revealed a correlation between artemisinin concents and the copy number of amorpha-4,11-dienes ynthasegenes.This correlation was further confirmed by resequencing of 36A.annua samples with varied artemisinin contents.Circular consensus sequencing of transcripts facilitated the detection of paralog expression.Collectively,our study provides chromosome-level allele-aware genome assemblies for two A.annua strains and new insights into the biosynthesis of artemisinin and its regulation,which will contribute to conquering malaria worldwide. | Baosheng Liao Xiaofeng Shen Li Xiang Shuai Guo Shiyu Chen Ying Meng Yu Liang Dandan Ding Junqi Bai Dong Zhang Tomasz Czechowski Yi Li Hui Yao Tingyu Mai Caroline Howard Chao Sun Haitao Liu Jiushi Liu Jin Pei Jihai Gao Jigang Wang Xiaohui Qiu Zhihai Huang Hongyi Li Ling Yuan Jianhe Wei lan Graham Jiang Xu Boli Zhang Shilin Chen | 2022 | Molecular Plant2022，15，8： | 9 |
| 2 | EPR investigations of structure of humic acids from compost, soil, peat and soft brown coal upon oxidation and metal uptake显示文摘 | JEZIERSKI A CZECHOWSKI F JERZYKIEWICZ M | 2000 | Applied Magnetic Resonance2000，18，1： | 1 |
| 3 | Surfactant protein D as a biomarker for lung injury显示文摘 | Czechowski M Karpel E Duda I | 2008 | Anestezjol Intens Ter2008，40，1： | 1 |
| 4 | EPR investigations of structure ofhumic acids from compost, soil, peat and soft brown coal upon oxidation and metal uptake显示文摘 | Jezierski A Czechowski F Jerzykiewicz M | 2000 | Applied Magnetic Resonance2000，18，1： | 1 |
| 5 | Genome-wide identification and testing of superior reference genes for transcript normalization in Arabidopsis 显示文摘 | Czechowski T Stitt M Altmann T | 2005 | Plant Physiol2005，139，1： | 1 |
| 6 | Conventional radiography and ultrasonography in the diagnosis of small bowel obstruction and strangulation显示文摘 | Czechowski J | 1996 | Acta Radiol1996，37，2： | 1 |
| 7 | Manufacture and properties of Al2O3-TiN particulate composites显示文摘 | Zbigniew S Rak Jerzy Czechowski | 1998 | Journal of the European Ceramic Society1998，18，1998： | 1 |
| 8 | Supercritical fluid extracts from brown coal lithotypes and their group components-molecular composition of non-polar compounds显示文摘 | Franciszek Czechowski Marek Stolarski Bernd R T Simoneit | 2002 | Fuel2002，81，： | 1 |
| 9 | Genome-wide identification and testing of superior reference genes for transcript normalization in Arabidopsis显示文摘 | Czechowski T Stitt M Altmann T | 2005 | Plant Physiol2005，139，： | 1 |
| 10 | Genome-wide identification and testing of superior reference genes for transcript normalization in Arabidopsis显示文摘 | Czechowski T Stitt M Altmann T Udvardi MK Scheible WR | | 0，，01： | 1 |
| 11 | TAPP ver-sus TEP: a retrospective analysis 5 yearsafter laparoscopic transperitonealand totalendoscopic extraperitoneal repair in in-guinal and femoralhmiia显示文摘 | Czechowski A Schafinayer A | 2010 | Chiruig2010，74，12： | 1 |
| 12 | Manufacture and properties of Al2O3-TiN particulate composities显示文摘 | RAK Z S CZECHOWSKI J | 1998 | J Eur Ceram Soc1998，18，4： | 1 |
| 13 | Low-cycle fatigue of friction stir welded AlMg alloys 显示文摘 | Czechowski M | 2005 | J Mater Proc Techn2005，，： | 1 |
| 14 | Genome -Wide Identifi- cation and Testing of Superior Reference Genes for Transcript Nor- malization in Arabidopsis显示文摘 | Czechowski T Stitt M Altmann T | 2005 | Plant Physiology2005，139，1： | 1 |
| 15 | Genomewide identification and testing of superior reference genes for transcript normalization in Arabidopsis显示文摘 | Czechowski T Stitt M Altmann T | 2005 | Plant Physiol2005，139，： | 1 |
| 16 | Genome-wide iden- tifieation and testing of superior reference genes for transcript normalization in Arabidopsis 显示文摘 | Czechowski T Stitt M Altmann T | 2005 | Plant Physiol2005，139，： | 1 |
| 17 | Procalcitonin amplifies inducible nitric oxide synthase gene expression and nitricoxide production in vascular smooth muscle cells显示文摘 | Hoffmann G Czechowski M Schloesser M | 2002 | Crit Care Med2002，30，9： | 1 |
| 18 | Multiple-region scapular fractures had more severe chest injury than single-region fractures:a prospective study of 107 blunt trauma patients 显示文摘 | Tadros AM Lunsjo K Czechowski J | 2007 | J Trauma2007，63，4： | 1 |
| 19 | Genomewide identification and testing of superior reference genes for transcript normalization in Arabidopsis显示文摘 | Czechowski T Stitt M Altmann T | | 0，，01： | 1 |
| 20 | Genome-wide identification and testing of superior reference genes for transcript normalization in Arabi- dopsis 显示文摘 | Czechowski T Stitt M Altmann T | 2005 | Plant Physiol2005，139，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员