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| 1 | Relation of atrophic gastritis with Helicobacter pylori-CagA^+ and interleukin-1 gene polymorphisms显示文摘AIM: To determine the association of Helicobacter pylori (H pylori) CagA+ infection and pro-inflammatory poly-morphisms of the genes interleukin (IL)-1RN and IL-1B with the risk of gastric atrophy and peptic ulcers in a dyspeptic population in Costa Rica, a country with high incidence and mortality of gastric cancer. METHODS: Seven biopsy specimens, a fasting blood sample and a questionnaire concerning nutritional and sociodemographic factors were obtained from 501 con-secutive patients who had undergone endoscopy for dyspeptic symptoms. A histopathological diagnosis was made. Pepsinogen concentrations were analyzed by enzyme linked immunosorbent assay (ELISA). Infection with H pylori CagA+ was determined by serology and polymerase chain reaction (PCR). IL-1B and IL-1RN polymorphisms genotyping was performed by PCR-restriction fragment length polymorphism (PCR-RFLP)and PCR respectively. RESULTS: In this dyspeptic population, 86% were H pylori positive and of these, 67.8% were positive for CagA. Atrophic antral gastritis (AAG) was associated with CagA+ status [odd ratio (OR) = 4.1; P < 0.000] and fruit consumption (OR = 0.3; P < 0.00). Atrophic body gastritis (ABG) was associated with pepsinogen PGI/PGII < 3.4 (OR = 4.9; P < 0.04) and alcohol consumption (OR = 7.3; P < 0.02). Duodenal ulcer was associated with CagA+ (OR = 2.9; P < 0.04) and smoking (OR = 2.4; P < 0.04). PGI < 60 μg/L as well as PGI/PGII < 3.4 were associated with CagA+. CONCLUSION: In a dyspeptic population in Costa Rica, H pylori CagA+ is not associated with ABG, but it is a risk factor for AAG. The pro-inflammatory cytokine poly-morphisms IL-1B + 3945 and IL-1RN are not associated with the atrophic lesions of this dyspeptic population. | Rafaela Sierra Clas Une Vanessa Ramírez Warner Alpízar-Alpízar María I González José A Ramírez Antoine de Mascarel Patricia Cuenca Guillermo Pérez-Pérez Francis Mégraud | 2008 | World Journal of Gastroenterology2008，14，42： | 2 |
| 2 | Flavonoids from Inula viscosa 显示文摘 | Grande M Piera F Cuenca A | 1985 | Planta Med1985，51，4： | 1 |
| 3 | Scopulariopsis brevicaulis , a fungal pathogen resistant to broad- spectrum antifungal agents 显示文摘 | Cuenca - Estrella M Gomez - Lopez A Mellado E | 2003 | Antimicrob Agents Chemother2003，47，7： | 1 |
| 4 | Marchetti nailing of closed fresh humeral shaftfractures显示文摘 | Martinez A A Malillos M Cuenca J | 2004 | Chir Main2004，23，5： | 1 |
| 5 | Adenosine reverses a preestablished CC14 - induced micronodular cirrhosis through enhancing eollagenolytic aeivity and stimulating hepatocyte cell proliferation in rats 显示文摘 | HERNANDEZ MUAOZ R DIAZ MUAOZ M SUAREZ CUENCA J A | 2001 | Hepatology2001，34，41： | 1 |
| 6 | A paradoxical role for myeloid-derived suppressor cells in sepsis and trauma显示文摘 | Cuenca A G Delano M J Kelly-Scumpia K M | 2011 | Mol Med2011，17，34： | 1 |
| 7 | Surface deformation induced by water influx in the abandoned coal mines in Limburg,The Netherlands observed by satellite radar interferometry显示文摘 | Caro Cuenca M Hooper A J Hanssen R F | 2013 | Journal of Applied Geophysics2013，88，： | 1 |
| 8 | Hybrid E-tongue for the evaluation of sweetness and bitterness of soft drinks fortified with epigallocatechin gallate显示文摘 | Bulbarello A Cuenca M Schweikert L Mannino S Scampicchio M | | 0，，： | 1 |
| 9 | Investigation of gaseous ozone as an anti -fungal fumigant for stored wheat 显示文摘 | Wu J N Doan H Cuenca M A | 2006 | Chemical Technology and Biotechnology2006，81，： | 1 |
| 10 | Soybean,a promising health source显示文摘 | Mateos-Aparicio I Redondo Cuenca A Villanueva-Suárez M J | 2008 | Nutrición Hospitalaria2008，23，4： | 1 |
| 11 | Monot- erpenes and lignans from mikania saltensis 显示文摘 | Cuenca M D R Catalan C A N C6sar A N | 1991 | J Nat Prod1991，54，4： | 1 |
| 12 | Biodegradation of diesel fuel-contaminated wastewater using a three-phase fluidized bed reactor显示文摘 | Lohi A Alvarez Cuenca M Anania G | 2008 | Journal of Hazardous Materials2008，154，： | 1 |
| 13 | Soybean, a promising heahh source显示文摘 | Mateos-Aparicio I Redondo Cuenca A Villanueva-Su6rez M J | 2008 | Nutricion Hospitalaria2008，23，4： | 1 |
| 14 | Biodegradation of diesel fuel-contaminated wastewater using a three-phase fluidized bed reactor显示文摘 | Lohi A Alvarez Cuenca M Anania G | 2008 | Journal of Hazardous Materials2008，154，123： | 1 |
| 15 | Soil water balance of annual crop-native shrub systems in Senegal's Bassin:The missing link显示文摘 | Kizito F Sène M Dragila MI Lufala A Diedhou I Dossa E Cuenca R Selker J Dick RP | | 0，，： | 1 |
| 16 | Agreement of non-contact pachymetry after LASIK: comparison of combined scanning- slit/placido disc topography and specular microscopy显示文摘 | Lopez Miguel A Nieto JC Diez Cuenca M | 2010 | Eye2010，24，6： | 1 |
| 17 | Surface Deforma- tion Induced by Water Influx in the Abandoned Coal Mines in Limburg,The Netherlands Observed by Satellite Radar Inter- ferometry显示文摘 | Caro Cuenca M Hooper A J Hanssen R F | 2013 | Journal of Applied Geophysics2013，88，： | 1 |
| 18 | Pea pod, broad bean pod and okara, potential sources of func- tional compounds 显示文摘 | Mateos - Aparicio I Redondo - Cuenca A Villanueva - Su~trez M - J | 2010 | LWT -Food Science and Technology2010，43，： | 1 |
| 19 | Combined activity in vitro of caspofungin,amphotericin B,and azole agents against itraconazole-resistant clinical isolates of Aspergillus fumigatus显示文摘 | Cuenca Estrella M Gomez Lopez A Garcia Effron G | 2005 | Antimicrob Agents Chemother2005，49，3： | 1 |
| 20 | Randomized clinical trial of fixation vs nonfixation of mesh in total extraperitoneal inguinal hemioplasty 显示文摘 | Moreno-Egea A Martinez J A T Cuenca G M | 2004 | Archives Surgery2004，139，12： | 1 |
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