|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 在 esophagogastroduodenoscopy 使用 lidocaine 的实用性与 propofol 表现在镇静下面显示文摘 AIM:To determine whether topical lidocaine benefits esophagogastroduoduenoscopy(EGD) by decreasing propofol dose necessary for sedation or procedurerelated complications.METHODS:The study was designed as a prospective,single centre,double blind,randomised clinical trial and was conducted in 2012 between January and May(NCT01489891).Consecutive patients undergoing EGD were randomly assigned to receive supplemental topical lidocaine(L;50 mg in an excipient solution which was applied as a spray to the oropharynx) or placebo(P;taste excipients solution without active substance,similarly delivered) prior to the standard propofol sedation procedure.The propofol was administered as a bolus intravenous(iv) dose,with patients in the L and P groups receiving initial doses based on the patient’s American Society of Anaesthesiologists(ASA) classification(ASAⅠ-Ⅱ:0.50-0.60 mg/kg;ASA Ⅲ-Ⅳ:0.25-0.35 mg/kg),followed by 10-20 mg iv dose every 30-60 s at the anaesthetist’s discretion.Vital signs,anthropometric measurements,amount of propofol administered,sedation level reached,examination time,and the subjective assessments of the endoscopist’s and anaesthetist’s satisfaction(based upon a four point Likert scale) were recorded.All statistical tests were performed by the Stata statistical software suite(Release 11,2009;StataCorp,LP,College Station,TX,United States).RESULTS:No significant differences were found between the groups treated with lidocaine or placebo in terms of total propofol dose(310.7 ± 139.2 mg/kg per minute vs 280.1 ± 87.7 mg/kg per minute,P = 0.15) or intraprocedural propofol dose(135.3 ± 151.7 mg/kg per minute vs 122.7 ± 96.5 mg/kg per minute,P = 0.58).Only when the L and P groups were analysed with the particular subgroups of female,< 65-year-old,and lower anaesthetic risk level(ASA Ⅰ-Ⅱ) was a statistically significant difference found(L:336.5 ± 141.2 mg/kg per minute vs P:284.6 ± 91.2 mg/kg per minute,P = 0.03) for greater total propofol requirements).The total incidence of complications was also similar between the two groups,with the L group showing a complication rate of 32.2%(95%CI:21.6-45.0) and the P group showing a complication rate of 26.7%(95%CI:17.0-39.0).In addition,the use of lidocaine had no effect on the anaesthetist’s or endoscopist’s satisfaction with the procedure.Thus,the endoscopist’s satisfaction Likert assessments were equally distributed among the L and P groups:unsatisfactory,[L:6.8%(95%CI:2.2-15.5) vs P:0%(95%CI:0-4.8);neutral,L:10.1%(95%CI:4.2-19.9) vs P:15%(95%CI:7.6-25.7)];satisfactory,[L:25.4%(95%CI:10-29.6) vs P:18.3%(95%CI:15.5-37.6);and very satisfactory,L:57.6%(95%CI:54-77.7) vs P:66.6%(95%CI:44.8-69.7)].Likewise,the anaesthetist’s satisfaction Likert assessments regarding the ease of maintaining a patient at an optimum sedation level without agitation or modification of the projected sedation protocol were not affected by the application of lidocaine,as evidenced by the lack of significant differences between the scores for the placebo group:unsatisfactory,L:5.8%(95%CI:1.3-13.2) vs P:0%(95%CI:0-4.8);neutral,L:16.9%(95%CI:8.9-28.4) vs P:16.7%(95%CI:8.8-27.7);satisfactory,L:15.2%(95%CI:7.7-26.1) vs P:20.3%(95%CI:11.3-31.6);and very satisfactory,L:62.7%(95%CI:49.9-74.3) vs P:63.3%(95%CI:50.6-74.7).CONCLUSION:Topical pharyngeal anaesthesia is safe in EGD but does not reduce the necessary dose of propofol or improve the anaesthetist’s or endoscopist’s satisfaction with the procedure. | Felipe de la Morena Cecilio Santander Carlos Esteban Beatriz de Cuenca Juan Antonio García Javier Sánchez Ricardo Moreno | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，5： | 3 |
| 2 | Relation of atrophic gastritis with Helicobacter pylori-CagA^+ and interleukin-1 gene polymorphisms显示文摘AIM: To determine the association of Helicobacter pylori (H pylori) CagA+ infection and pro-inflammatory poly-morphisms of the genes interleukin (IL)-1RN and IL-1B with the risk of gastric atrophy and peptic ulcers in a dyspeptic population in Costa Rica, a country with high incidence and mortality of gastric cancer. METHODS: Seven biopsy specimens, a fasting blood sample and a questionnaire concerning nutritional and sociodemographic factors were obtained from 501 con-secutive patients who had undergone endoscopy for dyspeptic symptoms. A histopathological diagnosis was made. Pepsinogen concentrations were analyzed by enzyme linked immunosorbent assay (ELISA). Infection with H pylori CagA+ was determined by serology and polymerase chain reaction (PCR). IL-1B and IL-1RN polymorphisms genotyping was performed by PCR-restriction fragment length polymorphism (PCR-RFLP)and PCR respectively. RESULTS: In this dyspeptic population, 86% were H pylori positive and of these, 67.8% were positive for CagA. Atrophic antral gastritis (AAG) was associated with CagA+ status [odd ratio (OR) = 4.1; P < 0.000] and fruit consumption (OR = 0.3; P < 0.00). Atrophic body gastritis (ABG) was associated with pepsinogen PGI/PGII < 3.4 (OR = 4.9; P < 0.04) and alcohol consumption (OR = 7.3; P < 0.02). Duodenal ulcer was associated with CagA+ (OR = 2.9; P < 0.04) and smoking (OR = 2.4; P < 0.04). PGI < 60 μg/L as well as PGI/PGII < 3.4 were associated with CagA+. CONCLUSION: In a dyspeptic population in Costa Rica, H pylori CagA+ is not associated with ABG, but it is a risk factor for AAG. The pro-inflammatory cytokine poly-morphisms IL-1B + 3945 and IL-1RN are not associated with the atrophic lesions of this dyspeptic population. | Rafaela Sierra Clas Une Vanessa Ramírez Warner Alpízar-Alpízar María I González José A Ramírez Antoine de Mascarel Patricia Cuenca Guillermo Pérez-Pérez Francis Mégraud | 2008 | World Journal of Gastroenterology2008，14，42： | 2 |
| 3 | Good results with unreamed nail and bone grafting for humeral nonunion显示文摘 | ángel A Martínez Antonio Herrera Jorge Cuenca | 2002 | Acta Orthopaedica2002，，3： | 2 |
| 4 | Random ized clinical trial of fixation vs nonfixation of mesh in total extrapertioneal inguinal hemiop lasty显示文摘 | Moreno-Egea A Torralba Martinez JA Morales Cuenca G | 2004 | Arch Surg2004，139，12： | 1 |
| 5 | Novel retinoic acid generating activities in the neural tube and beart identified by conditional rescue of Raldh2 null mutant mice显示文摘 | Mic F A Haselback R J Cuenca A E | 2002 | Development2002，129，9： | 1 |
| 6 | Flavonoids from Inula viscosa 显示文摘 | Grande M Piera F Cuenca A | 1985 | Planta Med1985，51，4： | 1 |
| 7 | Randomized clinical trial of fixation vs nonfixation of mesh in total extraperitoneal inguinal hemioplasty显示文摘 | Moreno-Egea A Torralba Martinez JA Morales Cuenca G | 2004 | Arch Surg2004，139，12： | 1 |
| 8 | Angular variation of thermal Infrared emissivity for some natural surfaces from experimental measurements显示文摘 | Sobrino J A Juan Cuenca | 1999 | Applied Optics-LP1999，38，18： | 1 |
| 9 | Physiological modulation of intestinal motility by enteric dopaminergic neurons and the D2 receptor:analysis of dopamine receptor expression,location,development,and function in wild-type and knock-out mice显示文摘 | Li ZS Schmauss C Cuenca A | 2006 | J Neurosci2006，26，10： | 1 |
| 10 | Good results with unreamed nail and bone grafting for humeral nonunion:a retrospective study of 21 patients 显示文摘 | Martinez AA Herrera A Cuenca J | 2002 | Acta Orthop Scand2002，73，3： | 1 |
| 11 | Risk Factors for Preeclampsia:Results from a Cohort of Over 5000 Pregnancies in Spain显示文摘Objective:To determine the incidence of preeclampsia(PE)and preterm PE in Spain and to identify the risk factors for developing the disease.Methods:This is a multicenter prospective cohort study performed at six maternity units across Spain.Women with singleton pregnancies attending their first-trimester routine visit at the hospital were offered participation.Maternal and pregnancy characteristics,including mean arterial pressure,as well as ultrasound findings were recorded.Univariate and multivariate logistic regression analyses were performed to identify independent risk factors for subsequent development of PE.Results:A total of 5868 pregnancies were recruited for this study,including 174(3.0%)cases of PE,47(0.8%)cases of preterm PE and 127(2.2%)cases of term PE.Median maternal age was 33.9 years(interquartile range:30.1 to 36.9)and median gestational age at the routine visit was 12.7 weeks(interquartile range:12.3 to 13.0).However,293(5.0%)of the women were on aspirin treatment during pregnancy,likely reducing the true incidence of the disease.As expected,increasing body mass index(P<0.001),uterine artery pulsatility index(P=0.011)and mean arterial pressure(P<0.001),assisted conception(P=0.013),previous personal(P<0.001)or family history of PE(P=0.024)and chronic hypertension(P=0.001)were identified as independent risk factors for developing subsequent PE during pregnancy.Screening for PE by maternal factors alone leads to a detection rate of 36.8%(64/174)at 10.0%(587/5868)screen positive rate.Conclusion:In Spain,3.0%of singleton pregnancies are complicated by PE and 0.8%require delivery before term due to its severity.Screening of PE by risk factors alone is only able to detect about 40%of total PE at 10%screen-positive rate. | Diana Cuenca Valeria Rolle Katy de Paco Matallana Nuria Valiño Rocio Revello Begoña Adiego Manel Mendoza Belen Santacruz Maria del Mar Gil | 2021 | Maternal-Fetal Medicine2021，3，2： | 1 |
| 12 | Scopulariopsis brevicaulis , a fungal pathogen resistant to broad- spectrum antifungal agents 显示文摘 | Cuenca - Estrella M Gomez - Lopez A Mellado E | 2003 | Antimicrob Agents Chemother2003，47，7： | 1 |
| 13 | Compression therapyafter varicose vein surgery: Can the classic elastic bandage be improved upon?显示文摘 | Morales Cuenca G Moreno Egla A AguayoAlbasini JL | 2011 | Cir Esp2011，89，9： | 1 |
| 14 | Marchetti nailing of closed fresh humeral shaftfractures显示文摘 | Martinez A A Malillos M Cuenca J | 2004 | Chir Main2004，23，5： | 1 |
| 15 | Adenosine reverses a preestablished CC14 - induced micronodular cirrhosis through enhancing eollagenolytic aeivity and stimulating hepatocyte cell proliferation in rats 显示文摘 | HERNANDEZ MUAOZ R DIAZ MUAOZ M SUAREZ CUENCA J A | 2001 | Hepatology2001，34，41： | 1 |
| 16 | Randomized clinical trial of fixation vs nonfixa- tion of mesh in total extraperitoneal inguinal hemioplasty 显示文摘 | Moreno-Egea A Torralba Martinez JA Morales Cuenca G | 2004 | Arch Surg2004，139，12： | 1 |
| 17 | Randomized clinical trial of fixation vs nonfixation of mesh in total extraperitoneal in-guinal hernioplasty显示文摘 | Moreno-Egea A Torralba Martinez JA Morales Cuenca G | 2004 | Arch Surg2004，139，12： | 1 |
| 18 | Randomized clinical trial of fixation vs nonfixation of mesh in total extraperitoneal inguinal hernioplasty 显示文摘 | Moreno-Egea A Torralba Martlnez JA Morales Cuenca G | 2004 | Arch Surg2004，139，12： | 1 |
| 19 | A paradoxical role for myeloid-derived suppressor cells in sepsis and trauma显示文摘 | Cuenca A G Delano M J Kelly-Scumpia K M | 2011 | Mol Med2011，17，34： | 1 |
| 20 | A critical role for Stat3 signaling in immune tolerance显示文摘 | Cheng F Wang HW Cuenca A | 2003 | Immunity2003，19，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员