|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Alcoholic liver disease:Utility of animal models显示文摘Alcoholic liver disease(ALD) is a major cause of acute and chronic liver injury. Extensive evidence has been accumulated on the pathological process of ALD during the past decades. However, effective treatment options for ALD are very limited due to the lack of suitable in vivo models that recapitulate the full spectrum of ALD. Experimental animal models of ALD, particularly rodents, have been used extensively to mimic human ALD. An ideal animal model should recapitulate all aspects of the ALD process, including significant steatosis, hepatic neutrophil infiltration, and liver injury. A better strategy against ALD depends on clear diagnostic biomarkers, accurate predictor(s) of its progression and new therapeutic approaches to modulate stop or even reverse the disease. Numerous models employing rodent animals have been established in the last decades to investigate the effects of acute and chronic alcohol exposure on the initiation and progression of ALD. Although significant progress has been made in gaining better knowledge on the mechanisms and pathology of ALD, many features of ALD are unknown, and require further investigation, ideally with improved animal models that more effectively mimic human ALD. Although differences in the degree and stages of alcoholic liver injury inevitably exist between animal models and human ALD, the acquisition and translational relevance will be greatly enhanced with the development of new and improved animal models of ALD. | Arantza Lamas-Paz Fengjie Hao Leonard J Nelson Maria Teresa Vázquez Santiago Canals Manuel Gómez del Moral Eduardo Martínez-Naves Yulia A Nevzorova Francisco Javier Cubero | 2018 | World Journal of Gastroenterology2018，24，45： | 26 |
| 2 | Dissecting the molecular pathophysiology of drug-induced liver injury显示文摘Drug-induced liver injury(DILI) has become a major topic in the field of Hepatology and Gastroenterology. DILI can be clinically divided into three phenotypes: hepatocytic, cholestatic and mixed. Although the clinical manifestations of DILI are variable and the pathogenesis complicated, recent insights using improved preclinical models, have allowed a better understanding of the mechanisms that trigger liver damage. In this review, we will discuss the pathophysiological mechanisms underlying DILI. The toxicity of the drug eventually induces hepatocellular damage through multiple molecular pathways, including direct hepatic toxicity and innate and adaptive immune responses. Drugs or their metabolites, such as the common analgesic, acetaminophen, can cause direct hepatic toxicity through accumulation of reactive oxygen species and mitochondrial dysfunction. The innate and adaptive immune responses play also a very important role in the occurrence of idiosyncratic DILI. Furthermore, we examine common forms of hepatocyte death and their association with the activation of specific signaling pathways. | Hui Ye Leonard J Nelson Manuel Gómez del Moral Eduardo Martínez-Naves Francisco Javier Cubero | 2018 | World Journal of Gastroenterology2018，24，13： | 19 |
| 3 | The Phosphate Transporter PHT4;6 Is a Determinant of Salt Tolerance that Is Localized to the Golgi Apparatus of Arabidopsis显示文摘破坏 PHT4 的功能的插入变化;(At5g44370 ) 6 引起 NaCl 被主要的根的减少的生长根尖端描绘,提高的侧面的分叉,并且胀大的 Arabidopsis 幼苗的超敏性。变异的显型被蔗糖,然而并非由甘露糖醇的 equiosmolar 集中加重,并且在媒介由低无机的磷酸盐稀释了。蛋白质 PHT4; 6 属于分享重要顺序类似到哺乳动物的类型的 permeases 的主要 Facilitator 总科 -- 我 Pi transporters 和小囊的 glutamate transporters,并且是植物的通常认为的细胞内部的磷酸盐 transporters 的 PHT4 家庭的一个成员。PHT4; 6 本地化那 PHT4 到膜和运输研究显示的 Golgi; 6 便于 Pi 然而并非氯化物或无机的阴离子的选择运输。有显示根胀大的另外的异种的 Phenotypic 类似建议那 PHT4;在蛋白质 N-glycosylation 和房间的 6 可能的功能围生合成,它为盐忍耐是必要的。一起,我们的结果显示那 PHT4;从为再循环免除 glycosylation 的 Pi 的 Golgi lumenal 空间的 6 运输 Pi 处理。 | Beatriz Cubero Yuko Nakagawa Xing-Yu Jiang Ken-Ji Miura Fang Li Kashchandra G. Raghothama Ray A. Bressan Paul M. Hasegawa Jose M. Pardo | 2009 | Molecular Plant2009，2，3： | 15 |
| 4 | Clinical scenarios for the use of S100β as a marker of hepatic encephalopathy显示文摘AIM: To evaluate the association between serum concentrations of S100β in patients with cirrhosis and the presence of low grade hepatic encephalopathy(HE).METHODS: This was a cross-sectional study. The population was categorized into four groups healthy subjects, cirrhosis without HE, cirrhosis with covert hepatic encephalopathy(CHE) and cirrhosis with overt HE. Kruskal-Wallis, Mann Whitney's U with Bonferroni adjustment Spearman correlations and area under the ROC were used as appropriate.RESULTS: A total of 61 subjects were included, 46 cirrhotic patients and 15 healthy volunteers. S100β values were different among all groups, and differences remained significant between groups 1 and 2(P < 0.001), and also between groups 2 and 3(P = 0.016), but not between groups 3 and 4. In cirrhotic patients with HE S100β was higher than in patients without HE [0.18(0.14-0.28) ng/m L vs 0.11(0.06-0.14) ng/m L, P < 0.001]. There was a close correlation between serum concentrations of S100β and psychometric hepatic encephalopathy score in patients with cirrhosis without HE compared to the patients with cirrhosis with CHE(r =-0.413, P = 0.019). ROC curve analysis yielded > 0.13 ng/m L as the best cutoff value of S100β for the diagnosis of HE(sensitivity 83.3%, specificity 63.6%).CONCLUSION: Serum concentrations of S100β are higher in patients with cirrhosis than in healthy volunteers, and are further increased in the presence of hepatic encephalopathy. The results suggest that serum biomarkers such as S100β could help in the correct characterization of incipient stages of HE. | Andrés Duarte-Rojo Astrid Ruiz-Margáin Ricardo U Macias-Rodriguez Francisco Javier Cubero José Estradas-Trujillo Rosa Ma Munoz-Fuentes Aldo Torre | 2016 | World Journal of Gastroenterology2016，22，17： | 4 |
| 5 | Low phase angle is associated with the development of hepatic encephalopathy in patients with cirrhosis显示文摘AIM Evaluate the association between phase angle and the development of hepatic encephalopathy in the longterm follow-up of cirrhotic patients.METHODS This was a prospective cohort study. Clinical, nutritional and biochemical evaluations were performed. MannWhitney's U and χ2 tests were used as appropriate. Kaplan-Meier curves and Cox proportional Hazards analysis were used to evaluate the prediction and incidence of hepatic encephalopathy.RESULTS Two hundred and twenty were included; the most frequent etiology of cirrhosis was hepatitis C infection, 52% of the patients developed hepatic encephalopathy(18.6% covert and 33.3% overt); the main precipitating factors were infections and variceal bleeding. KaplanMeier curves showed a higher proportion of HE in the group with low phase angle(39%) compared to the normal phase angle group(13%)(P = 0.012). Furthermore, creatinine and phase angle remained independently associated to hepatic encephalopathy in the Cox regression multivariate analysis [hazard ratio = 1.80(1.07-3.03)]. CONCLUSION In our cohort of patients low phase angle was associated with an increased incidence of hepatic encephalopathy. Phase angle is a useful nutritional marker that evaluates cachexia and could be used as a part of the integral assessment in patients with cirrhosis. | Astrid Ruiz-Margáin Ricardo Ulises Macías-Rodríguez Javier Ampuero Francisco Javier Cubero Luis Chi-Cervera Silvia L Ríos-Torres Andrés Duarte-Rojo Ángeles Espinosa-Cuevas Manuel Romero-Gómez Aldo Torre | 2016 | World Journal of Gastroenterology2016，22，45： | 4 |
| 6 | Extracellular vesicles in liver disease and beyond显示文摘Extracellular vesicles(EVs) are membrane-derived vesicles which can be released by different cell types, including hepatocytes, hepatic stellate cells and immune cells in normal and pathological conditions. EVs carry lipids, proteins, coding and non-coding RNAs and mitochondrial DNA causing modifications on the recipient cells. These vesicles are considered potential biomarkers and therapeutic agents for human diagnostic and prognostic due to their function as intercellular mediators of cell-cell communication within the liver and between other organs. However, the development and optimization of methods for EVs isolation is required to characterize their biological functions as well as their potential as a treatment option in the clinic. Nevertheless, many questions remain unanswered related to the function of EVs under physiological and pathological conditions. In the current editorial, the results obtained in different studies that investigated the role of intrahepatic EVs during liver diseases, including drug-induced liver injury, non-alcoholic fatty liver, nonalcoholic steatohepatitis, alcoholic liver disease and hepatocellular carcinoma and extrahepatic EVs in remote organs during pathological events such as pulmonary disease, cardiovascular diseases, neurodegenerative disorders e.g., Alzheimer's disease, Parkinson's disease and multiple sclerosis as well as in immunopathological processes, are discussed. Although much light needs to be shed on the mechanisms of EVs, these membranederived vesicles represent both a novel promising diagnostic, and a therapeutic tool for clinical use that we emphasize in the current editorial. | Laura Morán Francisco Javier Cubero | 2018 | World Journal of Gastroenterology2018，24，40： | 3 |
| 7 | Recent Advances and Applications of Hyperspectral Imaging for Fruit and Vegetable Quality Assessment显示文摘 | D. Lorente N. Aleixos J. Gómez-Sanchis S. Cubero O. L. García-Navarrete J. Blasco | 2012 | Food and Bioprocess Technology2012，，4： | 2 |
| 8 | Overexpression of c-myc in hepatocytes promotes activation of hepatic stellate cells and facilitates the onset of liver fibrosis显示文摘 | Yulia A. Nevzorova Wei Hu Francisco J. Cubero Ute Haas Julia Freimuth Frank Tacke Christian Trautwein Christian Liedtke | 2013 | BBA - Molecular Basis of Disease2013，，10： | 2 |
| 9 | Recent Advances and Applications of Hyperspectral Imaging for Fruit and Vegetable Quality Assessment显示文摘 | D. Lorente N. Aleixos J. Gómez-Sanchis S. Cubero O. L. García-Navarrete J. Blasco | 2012 | Food and Bioprocess Technology2012，，4： | 2 |
| 10 | Differential expression and function of Arabidopsis thaliana NHX Na^+/H^+ antiporters in the salt stress response显示文摘 | Yokoi1 S Francisco J Q Cubero B | 2002 | The Plant Journal2002，30，5： | 1 |
| 11 | Expression of activation molecules in neutrophils,monocytes and lymphocytes from patients with unstable angina treated with stent implantation显示文摘 | Sánchez-Margalet V Cubero JM Martín-Romero C | 2004 | Clin Chem Lab Med2004，42，3： | 1 |
| 12 | Decolorization of molasses effluents by coagulation-flocculation process显示文摘 | Benito G G Miranda M P Cubero M T G | 1999 | Sugar Industry1999，124，5： | 1 |
| 13 | Sulbactam efficacy in experimental models caused by susceptible and intermediate Acinetobacter baumannii strains 显示文摘 | Rodriguez-Hemandcz M J Cuberos L Pichardo C | 2001 | J Antimicrob Chemother2001，47，4： | 1 |
| 14 | Differential effects of peroxisome proliferator-activated receptor activators on the mRNA levels of genes involved in lipid metabolism in primary human monocyte-derived macrophages显示文摘 | Cabrero A Cubero M Laverias G | 2003 | Metabolism2003，52，5： | 1 |
| 15 | Genetic relationship amongworldwide strains of Xanthomonas causing canker in citrus spicies and design of new primers for their idetification by PCR显示文摘 | Cubero J Graham J H | 2002 | Appl Environ Microbiol2002，，68： | 1 |
| 16 | In-line sorting of irregular potatoes by using automated computer-based machine vision system显示文摘 | Gamal ElMasry Sergio Cubero Enrique Moltó José Blasco | 2012 | Journal of Food Engineering . 2012 (1-2)2012，，： | 1 |
| 17 | TBAR: An efficient method for association rule mining in relational databases显示文摘 | F Berzal J Cubero N Matin | 2001 | Data anti Knowl- edge Engineering2001，37，1： | 1 |
| 18 | Recent Advances and Applications of Hyperspectral Imaging for Fruit and Vegetable Quality Assessment显示文摘 | D. Lorente N. Aleixos J. Gómez-Sanchis S. Cubero O. L. García-Navarrete J. Blasco | 2012 | Food and Bioprocess Technology2012，，4： | 1 |
| 19 | Prediction of infarction related artery occlusion and multivessel disease in postinfarction anggina显示文摘 | Valenzuela LF Cubero J Cruz-Fernandez JM | 2007 | Int J Cardio2007，115，3： | 1 |
| 20 | Crystal structure of low magnesium-content alite: Application to Rietveld quantitative phase analysis 显示文摘 | DELATORRE A G DEVERA R N CUBEROS A J M | 2008 | Cem Concr Res2008，38，11： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员