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| 1 | Low phase angle is associated with the development of hepatic encephalopathy in patients with cirrhosis显示文摘AIM Evaluate the association between phase angle and the development of hepatic encephalopathy in the longterm follow-up of cirrhotic patients.METHODS This was a prospective cohort study. Clinical, nutritional and biochemical evaluations were performed. MannWhitney's U and χ2 tests were used as appropriate. Kaplan-Meier curves and Cox proportional Hazards analysis were used to evaluate the prediction and incidence of hepatic encephalopathy.RESULTS Two hundred and twenty were included; the most frequent etiology of cirrhosis was hepatitis C infection, 52% of the patients developed hepatic encephalopathy(18.6% covert and 33.3% overt); the main precipitating factors were infections and variceal bleeding. KaplanMeier curves showed a higher proportion of HE in the group with low phase angle(39%) compared to the normal phase angle group(13%)(P = 0.012). Furthermore, creatinine and phase angle remained independently associated to hepatic encephalopathy in the Cox regression multivariate analysis [hazard ratio = 1.80(1.07-3.03)]. CONCLUSION In our cohort of patients low phase angle was associated with an increased incidence of hepatic encephalopathy. Phase angle is a useful nutritional marker that evaluates cachexia and could be used as a part of the integral assessment in patients with cirrhosis. | Astrid Ruiz-Margáin Ricardo Ulises Macías-Rodríguez Javier Ampuero Francisco Javier Cubero Luis Chi-Cervera Silvia L Ríos-Torres Andrés Duarte-Rojo Ángeles Espinosa-Cuevas Manuel Romero-Gómez Aldo Torre | 2016 | World Journal of Gastroenterology2016，22，45： | 4 |
| 2 | Sulbactam efficacy in experimental models caused by susceptible and intermediate Acinetobacter baumannii strains 显示文摘 | Rodriguez-Hemandcz M J Cuberos L Pichardo C | 2001 | J Antimicrob Chemother2001，47，4： | 1 |
| 3 | A method fordetermining regioisomer abundances of polyunsaturated triacyl-glycerols in omega-3 enriched fish oils using reversed-phase liq-uid chromatography and triple-stage mass spectrometry 显示文摘 | Cubero Herrera L Ramaley L Potvin MA | 2013 | FoodChem2013，139，1234： | 1 |
| 4 | Ameva:an autonomous discretization algorithm 显示文摘 | GONZALEZ A L CUBEROS F J VELASCO F | 2008 | Expert Systems with Applications2008，36，3： | 1 |
| 5 | Sulbactam efficacy in experimental models caused by susceptible and intermediate Acinetobacter baumannii strains显示文摘 | Rodriguez-Hernandez MJ Cuberos L Pichardo C | 2001 | J Antimicrob Chemother2001，47，4： | 1 |
| 6 | A method for determining regioisomer abundances of poly-unsaturated triacylglycerols in omega-3 enriched fish oils using reversed-phase liquid chromatography and triple-stage mass spectrometry显示文摘 | Cubero Herrera L Ramaley L Potvin MA | | 0，，1： | 1 |
| 7 | Sulbactam efficacy in experimental models caused by susceptible and intermediate Acinetobacter baumannii strains 显示文摘 | Rodrguez-Hemtndez MJ Cuberos L Pichardo C | 2001 | J Antimicrob Chemother2001，47，4： | 1 |
| 8 | Transgenic tobacco expressing a Trichoderma harzianum endochitinase encoding gene显示文摘 | Garcia L Cubero B Lorito M | 1997 | Phytopathology1997，，： | 1 |
| 9 | Sulbactam efficacy in experimental models caused by susceptible and intermediate Acinetobacter baumannii strains显示文摘 | RODRIGUEZ-HERNANDEZ M J CUBEROS L PICHARDO C | 2001 | J Antimicrob Chemother2001，47，4： | 1 |
| 10 | A simple extraction procedure for efficient routine detection of pathogenic bacteria in plant material by polymerase chain reaction显示文摘 | Pablo Llop Paola Caruso Jaime Cubero Clara Morente Mar??a M López | 1999 | Journal of Microbiological Methods1999，，1： | 1 |
| 11 | Primitive and modern forms of Vicia faba 显示文摘 | Cubero J l Suso M | 1981 | Genet Res Crop Evol1981，29，1： | 1 |
| 12 | Sulbactam efficacy in experimental models caused by susceptible and intermediate Acinetobacter baumannii strains显示文摘 | Rodriguez-Hernandez M J Cuberos L Pichardo C | 2001 | J Antimicrob Chemother2001，47，4： | 1 |
| 13 | Molecular epidemiology and putative origin of hepatitis C virus in random volunteers from Argentina显示文摘AIM:To study the subtype prevalence and the phylogenetic relatedness of hepatitis C virus(HCV)sequences obtained from the Argentine general population,a large cohort of individuals was analyzed.METHODS:Healthy Argentinian volunteers(n=6251)from 12 provinces representing all geographical regions of the country were studied.All parents or legal guardians of individuals younger than 18 years provided informed written consent for participation.The corresponding written permission from all municipal authorities was obtained from each city or town where subjects were to be included.HCV RNA reverse transcription-polymerase chain reaction products were sequenced and phylogenetically analyzed.The 5’untranslated region(5’UTR)was used for RNA detection and initial genotype classification.The NS5B polymerase region,encompassing nt 8262-8610,was used for subtyping.RESULTS:An unexpectedly low prevalence of HCV infection in the general population(0.32%)was observed.Our data contrasted with previous studies that reported rates ranging from 1.5%to 2.5%,mainly performed in selected populations of blood donors or vulnerable groups.The latter values are in keeping with the prevalence reported by the 2007 Argentinian HCV Consensus(approximately 2%).HCV subtypes weredistributed as follows:1a(25%),1b(25%),2c(25%),3a(5%),and 2j(5%).Two isolates ascribed either to genotype 1(5%)or to genotype 3(5%)by 5’UTR phylogenetic analysis could not be subtyped.Subtype 1a sequences comprised a highly homogeneous population and clustered with United States sequences.Genotype1b sequences represented a heterogeneous population,suggesting that this genotype might have been introduced from different sources.Most subtype 2c sequences clustered close to the 2c reported from Italy and Southern France.CONCLUSION:HCV has a low prevalence of 0.32%in the studied general population of Argentina.The pattern of HCV introduction and transmission in Argentina appears to be a consequence of multiple events and different for each subtype. | Noemí del Pino José Raúl Oubia Francisco Rodríguez-Frías Juan Ignacio Esteban María Buti Teresa Otero Josep Gregori Damir García-Cehic Silvia Camos María Cubero Rosario Casillas Jaume Guàrdia Rafael Esteban Josep Quer | 2013 | World Journal of Gastroenterology2013，19，35： | 1 |
| 14 | Magnetic behavior in arrays of Ni79Fe21 and Ni79Fe21/Cu nanowires显示文摘 | Elbaile L Cubero I G Crespo R D | 2012 | Journal of Alloys and Compounds2012，，536： | 1 |
| 15 | Sulbactam efficacy in experimental models caused by susceptible and intermediate Acinetobacter baumannii strains显示文摘 | Rodriguez Hernandez MJ Cuberos L Pichardo C etal | 2001 | J Antimicrob Chemother2001，47，4： | 1 |
| 16 | Screening for human milk amino Acids by HPLC-ESI-MS/MS显示文摘 | S6nchez C L Cubero J S6nchez J | 2011 | Food Analytical Methods2011，5，2： | 1 |
| 17 | Ameva: An autono- mous discretization algorithm 显示文摘 | Gonzalez Abril L Cuberos F J Velascoa F | 2009 | Expert Systems with Applications2009，36，3： | 1 |
| 18 | Sulbactam efficacy in experimental models caused by sus ceptible and intermediate Acinetobacter baumannii strains 显示文摘 | Rodriguez-Hernandez MJ Cuberos L Pichardo C | 2001 | J Antimicrob Chemother2001，47，4： | 1 |
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