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| 1 | Wegener肉芽肿病CD4^+CD28^-T细胞的免疫表型及功能的研究显示文摘目的 研究Wegener 肉芽肿病( Wegener′s granulomatosis,WG) 协同刺激分子(costimulatory molecules,CosM)CD28/CTLA4CD80/CD86 的表达以及CD4 + CD28 - T 细胞的免疫表型特征和功能。方法 CosM 的表达用FACS多参数分析测定。CD4 + CD28- T细胞与不同刺激剂共同培养后测定其增生反应的程度及细胞因子的分泌。结果 WG 外周血中CD4 + CD28 - T 细胞明显增多。它们表达CD25、CD38 、CD45RO、HLADR 以及CD86 显著增加,且对自身抗原蛋白酶3 的刺激呈明显增生反应。在抗原提呈细胞(antigen presenting cell,APC) 及抗CD3 共同作用下,CD4+CD28- T 细胞的增生活跃,但这种增生反应不能被CTLA4 Ig、抗CD80 及抗CD86 所抑制。CD4+CD28- T细胞分泌IFNγ的量明显高于CD4 + CD28 - T 细胞。另外,CD4 + CD28 - T 细胞还能诱导正常CD4 + T 细胞的活化和增生。结论 WGCD4 + CD28- T 细胞明显增多,它们可能是一类已被活化的自身? | 王国春 王晓娣 Csernok E Gross W L | 1999 | 中华风湿病学杂志1999，3，4： | 3 |
| 2 | Update on the pathogenesis of Churg-Strauss syndrome显示文摘 | Hellmich B Ehlers S Csernok E | 2003 | Clin Exp Rheumatol2003，21，632： | 1 |
| 3 | Anti neutrophil cytoplastic antibodies (ANCA) directed against bactericidal permeability inereasing protein (BP1): A new seromarker for inflammatory bowel disease and associated disorders显示文摘 | Stoffel MP Csernok E Herzberg C | 1996 | Clin Exp Immunol1996，104，： | 1 |
| 4 | Anti-neutrophil cytoplasmic antibodies and pathogenesis of small vessel vasculitides显示文摘 | Csernok E | 2003 | Autoimmun Rev2003，2，3： | 1 |
| 5 | Immunopathology of ANCA-associated vasculitis显示文摘 | Csernok E Muller A Gross WL | 1999 | Intern Med1999，38，10： | 1 |
| 6 | 显示文摘 | Csernok E Holle J Hellmich B | 2004 | Rheumatology (Oxford)2004，43，2： | 1 |
| 7 | Anti-neutrophil cytoplasmic antibodies and pathogenesis of small vessel vasculitides显示文摘 | Csernok Elena | 2003 | Autoimmunity Reviews2003，2，3： | 1 |
| 8 | Prevalence and spectrum of rheumatic diseases associated with proteinase 3 - antineutrophil cytoplasmic antibodies (ANCA) and myeloperoxidase - AN- CA 显示文摘 | Sehonermarck U Amprecht P Csernok E | 2001 | Rheumatology2001，40，3： | 1 |
| 9 | Peripheral blood and granuloma CD4^+ CD28- T cells are a major source of interferon-γ and tumor necrosis factor-α in Wegener's granulomatosis显示文摘 | Komocsi A Lamprech P Csernok E | 2002 | Am J Pathol2002，160，5： | 1 |
| 10 | Cytokine profiles in Wegener's granulonatosis:predominance of type 1(Th1) in the granulomatous inflammation显示文摘 | Csernok E Trabandt A Muller A | 1999 | Arthritis Rheum1999，42，： | 1 |
| 11 | A critical evaluation of commercial immunoassays for antineutrophil cytoplasmic antibodies directed against proteinase 3 and myeloperoxidase in Wegener's granulomatosis and microscopic polyangiitis 显示文摘 | Csernok E Ahlquist D Ullrich S | 2002 | Rheumatology2002，41，11： | 1 |
| 12 | Antineutrophil cytoplasmic autoantibodies, autoantigens, and systemic vasculitis显示文摘 | Gross WL Csernok E Helmchen U | 1995 | APMIS1995，103，： | 1 |
| 13 | Use of native and recombinant bactericidal/permeability-increasing proteins (BPI)as antigens for detection of BPI-ANCA显示文摘 | Schultz H Csernok E Johnston TW | 1997 | J Immunol Methods1997，205，2： | 1 |
| 14 | Transforming growth factor-beta(TGF-beta) expression and interaction with proteinase 3 (PR3) in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis显示文摘 | Csernok E Szymkowiak CH Mistry N | 1996 | Clin Exp Immunol1996，105，1： | 1 |
| 15 | A novel high sensitive ELISA for detection of antineutrophil cytoplasm anti- bodies against proteinase-3显示文摘 | Hellmich B Csernok E Fredenhagen G | 2007 | Clin Exp Rheumatol2007，25，44： | 1 |
| 16 | Current and emerging techniques for ANCA detection in vasculitis显示文摘 | Csernok E Moosig F | 2014 | Nat Rev Rheumatol2014，10，8： | 1 |
| 17 | Cytokine profiles in Wegener's granulomatosis:predominance of type 1(Th1) in the granulomatous inflammation显示文摘 | Csernok E Trabandt A Mailer A | 1999 | Arthritis Rheum1999，42，： | 1 |
| 18 | Peripheral blood and granu- loma CIM( + )CD28( - ) T cells are a major source of interferon-gam- ma and tumor necrosis factor-alpha in Wegener' s granulomatosis 显示文摘 | Komocsi A Lamprecbt P Csernok E | 2002 | Am J Patho12002，160，5： | 1 |
| 19 | Comparison of eight commercial kits for quantitation of antineutrophil cytoplasmic antibodies (ANCA) 显示文摘 | Wang G Csernok E de Groot K | 1997 | Journal of Immunological Methods1997，208，： | 1 |
| 20 | Peripheral blood and granuloma CD4 + CD28-T cells are a major source of interferon-γ and tumor necrosis factor-α in Wegener's granulomatosis显示文摘 | Komocsi A Lamprecht P Csernok E | | 0，，： | 1 |
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