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| 1 | Current and future treatments for hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC) represents a unique challenge for physicians and patients.There is no definitively curative treatment.Rather,many treatment and management modalities exist with differing advantages and disadvantages.Both current guidelines and individual patient concerns must be taken into account in order to properly manage HCC.In addition,quality of life issues are particularly complex in patients with HCC and these concerns must also be factored into treatment strategies.Thus,considering all the options and their various pros and cons can quickly become complex for both clinicians and patients.In this review,we systematically discuss the current treatment modalities available for HCC,detailing relevant clinical data,risks and rewards and overall outcomes for each approach.Surgical options discussed include resection,transplantation and ablation.We also discuss the radiation modalities:conformal radiotherapy,yttrium 90 microspheres and proton and heavy ion radiotherapy.The biologic agent Sorafenib is discussed as a promising new approach,and recent clinical trials are reviewed.We then detail currently described molecular pathways implicated in the initiation and progression of HCC,and we explore the potential of each pathway as an avenue for drug exploitation.We hope this comprehensive and forward-looking review enables both clinicians and patients to understand various options and thereby make more informed decisions regarding this disease. | Alexander Schlachterman Willie W Craft Jr Eric Hilgenfeldt Avir Mitra Roniel Cabrera | 2015 | World Journal of Gastroenterology2015，21，28： | 76 |
| 2 | Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study显示文摘 | Mark S Pearce Jane A Salotti Mark P Little Kieran McHugh Choonsik Lee Kwang Pyo Kim Nicola L Howe Cecile M Ronckers Preetha Rajaraman Alan W Craft Louise Parker Amy Berrington de González | 2012 | The Lancet . 2012 (9840)2012，，： | 3 |
| 3 | Sediment and nutrient accumulation in floodplain and depressional freshwater wetlands of Georgia, USA显示文摘 | Craft C B and Casey W P | 2000 | Wetlands2000，20，2： | 1 |
| 4 | Toxicity of arsenic, borax, chlorate and their combinations in three California soils显示文摘 | Crafts A S Cleary C W | 1936 | Hilgardia1936，10，： | 1 |
| 5 | Electrical derivarive characteristics of InGaAsP buried heterostructure lasers显示文摘 | Wright P D Joyce W B Craft D C | 1982 | J Appl Phys1982，53，： | 1 |
| 6 | Induction of ovulation for in vitro fertilization using buserelin and gonadotropins显示文摘 | PORTER RN SMITH W CRAFT IL | 1984 | Lancet1984，2，8414： | 1 |
| 7 | Induction of ovulation for in vitro fertilization using buserelin and gonadotrophins 显示文摘 | Porter RN Smith W Craft IL | 1984 | Lancet1984，2，84414： | 1 |
| 8 | Induction of ovulation of ovulation for invitro using buserelin and gonadotropins 显示文摘 | Porter RN Smith W Craft IL | 1984 | Lanect1984，2，8414： | 1 |
| 9 | Induction of ovulation for in vitro fertilization using buserelin and gonadotropins显示文摘 | Porter RN Smith W Craft L | 1984 | Lancet1984，2，： | 1 |
| 10 | Induction of ovulation for in vitro fertilization using buserelin and gonadotrophins显示文摘 | Porter RN Smith W Craft IL | 1984 | Lancet1984，2，8414： | 1 |
| 11 | Induction of ovulation for in-vitro fertilization using buserelin and gonadotropins 显示文摘 | PORTER R N SMITH W CRAFT I L | 1984 | Lancet1984，2，8414： | 1 |
| 12 | Impinging jet studies for turbulence model assessment Part Ⅱ:an examination of the performance of four turbulence models显示文摘 | CRAFT T J GRAHAM L J W LAUNDER B E | | 0，，： | 1 |
| 13 | Induction of ovulation for in-vitro fertilisation using buserelin and gonadotropins 显示文摘 | Porter RN Smith W Craft IL | 1984 | Lancet1984，2，8414： | 1 |
| 14 | Induction of ovulation for in vitro fertilization using buserelin and gonadotropins 显示文摘 | Porter RN Smith W Craft IL | 1984 | Lancet1984，2，8414： | 1 |
| 15 | Effects of four years of nitrogen and phosphorus additions on everglades plant communities显示文摘 | CHIANG C CRAFT C B ROGERS D W | | 0，，01： | 1 |
| 16 | A systematic review of the effectiveness of magnetic resonance imaging (MRI) as an addition to mammography and ultrasound in screening young women at high risk of breast cancer显示文摘 | Lord SJ Lei W Craft P | 2007 | Eur J Cancer2007，43，13： | 1 |
| 17 | Glucocorticoid- induced impairment in declarative memory performance in adult human显示文摘 | Newcomer J W Craft S Hershey T | 1994 | J Neurosci1994，14，4： | 1 |
| 18 | Induction of ovulation for in vitro fertilization using buserelin and gonadotrophins显示文摘 | Porter RN Smith W Craft IL | 1984 | Lancet1984，2，8414： | 1 |
| 19 | Absorption and mal absorption of glycine and glycine peptides in man显示文摘 | CRAFT I L GEDDES D HYDE C W | 1968 | Gut1968，9，4： | 1 |
| 20 | Induction of ovulation for in-vitro fertilization using buserelin and gonadotropins 显示文摘 | Porter RN Smith W Craft IL | 1984 | Lancet1984，2，： | 1 |
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