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| 1 | 限制热量摄入6个月对超重者寿命指标、代谢调节及氧化应激的影响——随机对照试验AuthorAffiliations:PenningtonBiomedicalResearchCenter.LouisianaStateUniversity.BatonRouge;andGarvan.InstituteforMedicalResearch.Dadinghurst,AustraIia(DrHeilbronn).显示文摘背景:长期限制热量摄入可延长啮齿类动物的寿命。但是,尚未有研究观测长期限制人体热量是否会影响其寿命及氧化应激指标,降低代谢率。
目的:在超重但不肥胖(体重指数为25—30)的人群中研究限制热量6个月伴/不伴运动对其产生的影响。
设计、地点及参试者:于2002年3月至2004年8月在位于路易斯安娜州首府巴顿鲁治的研究中心对48名不好动的健康人进行随机对照研究。
干预:参试者在6个月内随机分为4个组:对照组(饮食可维持体重);限制热量组(限制基线所需能量的25%);限制热量+运动组(限制12.5%的热量+运动增加12.5%的能耗);极低热量饮食组(每日摄入890keal,直至体重减少15%,随后采用维持体重的饮食)。
主要观测指标:机体组成;硫酸脱氢表雄酮(dehydroepiandrostemne sulfate,DHEAS)、葡萄糖及胰岛素水平;蛋白羰基化合物;DNA损伤;24小时能耗;核心体温。
结果:6个月时各组体重变化的均值(标准误)为:对照组-1.0%(1.1%);限制热量组-10.4%(0.9%);限制热量+运动组-10.0%(0.8%);极低热量饮食组-13.9%(0.7%)。6个月时,各干预组空腹血糖水平较基线明显降低(P均〈0.01),而DHEAS和葡萄糖水平没有改变。限制热量组及限制热量+运动组核心体温有所下降(P均〈0.05)。对机体组成进行校正后发现,对照组24小时静息能耗无变化,但限制热量组(-135kcal/d[42kcal/d])、限制热量+运动组(-117kcal/d[52kcal/d])和极低热量饮食组(-125kcal/d[35kcal/d])24小时静息能耗有所下降(P均〈0.008)。上述“代谢调节”(超出预计值的-6%)与对照组相比存在显著差异(P〈0.05)。6个月时,各组蛋白羰基化合物的浓度较基线时无变化,而各干预组DNA损伤有所减少(P〈0.005)。
结论:我们的研究结果显示,长期限制热量可降低人类寿命的2种指标(即空腹胰岛素水平和体温)。此外,我们的研究结果还支持下述理论,即限制热量能降低代谢率,且超过缩小代谢面积产生的相应效应。我们尚需开展远期研究来评价限制热量能否延缓人类衰老过程。 | Leonie K. Heibronn Lilian de Jonge Madlyn I. Frisard James P. DeLany D. Enette Larson-Meyer Jennifer Rood Tuong Nguyen Corby K. Martin Julia Volaufova Marlene M. Most Frank L. Greenway Steven R. Smith Walter A. Deutsch Donald A. Williamson Eric Ravussin 顾佳(译) | 2006 | 美国医学会杂志(中文版)2006，25，5： | 18 |
| 2 | Fundamental motor skills,screen-time,and physical activity in preschoolers显示文摘Purpose: To examine the associations among preschoolers fundamental motor skills, screen-time, physical activity(PA), and sedentary behavior(SB).Methods: Children ages 3à4 years were enrolled in a prospective observational trial of PA. Trained assessors conducted the Test of Gross Motor Development-3 rd edition(TGMD-3), and the Movement Assessment Battery for Children-2 nd edition, and parent-reported child screen-time and sociodemographic information. Children wore an accelerometer for 7 days to examine SB and total PA(TPA). TPA was further characterized as moderateto-vigorous PA(MVPA) or vigorous PA(VPA). Mixed linear models were calculated, controlling for age(for TGMD-3), sex, household income, and accelerometer wear time(for accelerometry models), with childcare center as a random effect. The primary analysis reported on the cross-sectional baseline data of 126 children with complete fundamental motor skill and screen-time data; a subanalysis included 88 children with complete accelerometry data.Results: Children were 3.4 § 0.5 years of age(54% girls; 46% white, 42% African American, 12% other). A total of 48% lived in households at or below the federal poverty level. Children engaged in 5.1 § 3.6 h/day of screen-time. Children's screen-time was inversely related to the Movement Assessment Battery for Children-2 nd edition, manual dexterity skills percentile(b(SE) = ?1.7(0.8), p = 0.049). In the accelerometry subsample,children engaged in 5.9 § 0.9 h/day of TPA of which 1.7 § 0.6 h/day was MVPA. Boys engaged in more MVPA and VPA and less SB compared with girls(all p < 0.05). A higher TGMD-3, total score(b(SE) = 0.4(0.2), p = 0.017) and locomotor score(b(SE) = 0.7(0.3), p = 0.018) were associated with more VPA but not with TPA or MVPA. Screen-time and television in the bedroom were not related to SB, TPA, MVPA, or VPA.Conclusion: Children's motor skills were positively related to VPA but inversely related to screen-time. Further inquiry into the implications of high exposure to screen-time in young children is needed. | E.Kipling Webster Corby K.Martin Amanda E.Staiano | 2019 | Journal of Sport and Health Science2019，8，2： | 12 |
| 3 | Cancer stem cells in colorectal cancer from pathogenesis to therapy: Controversies and perspectives显示文摘Colorectal cancer remains one of the most common and lethal malignancies worldwide despite the use of various therapeutic strategies.A better understanding of the mechanisms responsible for tumor initiation and progression is essential for the development of novel,more powerful therapies.The traditional,so-called'stochastic model'of tumor development,which assumes that each cancer cell is tumorigenic,has been deeply challenged during the past decade by the identification of cancer stem cells(CSCs),a biologically distinct subset of cells within the bulk of tumor mass.This discovery led to the development of the hierarchical model of tumorigenesis which assumes that only CSCs have the ability to initiate tumor growth,both at primary and metastatic sites.This model implies that the elimination of all CSCs is fundamental to eradicate tumors and that failure to do so might be responsible for the occurrence of relapses and/or metastases frequently observed in the clinical management of colorectal cancer patients.Identification and isolation of CSCs is essential for a better understanding of their role in the tumorigenetic process and for the development of CSC-specific therapies.Several methods have been used for this purpose and many efforts have been focused on the identification of specific CSC-surface markers.This review provides an overview of the proposed roles of CSC in human colorectal tumorigenesis focusing on the most important molecules identified as CSC-specific markers in colorectal cancer and on the potential strategies for the development of CSC-targeted therapy. | Caterina Fanali Donatella Lucchetti Marisa Farina Maddalena Corbi Valerio Cufino Achille Cittadini Alessandro Sgambato | 2014 | World Journal of Gastroenterology2014，20，4： | 7 |
| 4 | Properties and Applications of Bamboo Fiber—A Current-State-of-the Art显示文摘Fibers are used in many forms in engineering applications–one of the most common being used as reinforcement.Due to its renewable short natural growth cycle and abundance of bamboo resources,bamboo fiber has attracted attention over other natural fibers.Bamboo fiber has a complex natural structure but offers excellent mechanical properties,which are utilized in the textile,papermaking,construction,and composites industry.However,bam-boo fibers can easily absorb moisture and are prone to corrosion limiting their use in engineering applications.Therefore,a better understanding of bamboo fiber is particularly important.This paper reviews all existing research on the mechanical characterization of bamboo fiber with an emphasis on the extraction and treatment techniques,and their effect on relevant properties.The chemical composition of bamboo fibers has also been thoroughly investigated and presented herein.Current applications and future opportunities for bamboo fibers in various fields have been presented with a focus on research needs.This work can serve as a reference for future research on bamboo fiber. | Chen Chen Haitao Li Assima Dauletbek Feng Shen David Hui Milan Gaff Rodolfo Lorenzo Ileana Corbi Ottavia Corbi Mahmud Ashraf | 2022 | Journal of Renewable Materials2022，10，3： | 3 |
| 5 | Review on Connections for Original Bamboo Structures显示文摘Bamboo is a green construction material in line with sustainable development strategies.The use of raw bamboo in architecture has existed since ancient times.In the long development years of original bamboo buildings,many areas in the world gradually formed unique bamboo buildings,which have become an important local cultural feature.For building structures,joints are the key to ensure structural load transfer.Because of hollow and thin-walled material property of bamboo,the connection in raw bamboo buildings has always been a major difficulty and problem in the application of bamboo,which seriously hinders the development of original bamboo structures.In order to promote the use of raw bamboo,two traditional connection methods in raw bamboo structures are described in this paper firstly,with the advantages and disadvantages of the two methods pointed out.Also,research progress on four categories of raw bamboo building joints is described namely,bolt joints,steel member joints,filler reinforced joints and other types of joints.This work can provide a reference for future research and engineering applications. | Chaokun Hong Haitao Li Rodolfo Lorenzo Gang Wu Ileana Corbi Ottavia Corbi Zhenhua Xiong Dong Yang Huizhong Zhang | 2019 | Journal of Renewable Materials2019，7，8： | 3 |
| 6 | A Review of Basic Mechanical Behavior of Laminated Bamboo Lumber显示文摘Over the past decade,the physical and mechanical performances of laminated bamboo lumber(LBL)–a bamboo-based structural material,have been extensively studied using experimental,analytical,and numerical approaches.This paper presents a review of existing knowledge in the literature about the mechanical properties of LBL.The paper involved the review of the response of LBL to different types of loading such as tension,bending,compres-sion,and shear.Based on results of the literature reviewed,the strength of LBL parallel to grain was 90–124 MPa with MOE of 10700 MPa in tension,29.55–72.60 MPa,and MOE of 8396–11022 MPa in compression,63.87–128.4 MPa,and MOE of 8320–10912 MPa in bending,and 7.15–17.5 MPa in shear.The average strength of LBL was similar and in some cases exceeded the average values of bamboo-or wood-based materials,while the variability of its mechanical parameters was lower.The variability in strength values of LBL was affected by bamboo species,density and thickness of bamboo strips,growth portion,type of treatment,strips arrange-ments,and type of adhesive which in turn calls for classification of LBL by strength grades,degree of hardness,the capability of impregnation and penetration,as well as by areas of application in construction.The study pro-vided and discussed concluding observations,the current research gap,and future research directions on the mechanical properties of LBL. | Assima Dauletbek Haitao Li Rodolfo Lorenzo Ileana Corbi Ottavia Corbi Mahmud Ashraf | 2022 | Journal of Renewable Materials2022，10，2： | 2 |
| 7 | Secretion of IL-6,IL-11 and LIF by humAN cardiomyocytes in primary culture显示文摘 | ANCEY C CORBI P FROGER J | 2002 | Cytokine2002，18，4： | 1 |
| 8 | Secondary tricuspid regurgitation or dilatation:which should be the criteria for surgical repair显示文摘 | Dreyfus GD Corbi PJ Chan KM | | 0，，1： | 1 |
| 9 | A Review of Fibre Reinforced Polymer (FRP) Reinforced Concrete Composite Column Members Modelling and Analysis Techniques显示文摘The use of fibre-reinforced polymer(FRP)to confine concrete columns improves the strength and ductility of the columns by reducing passive lateral confinement pressure.Many numerical and analytical formulations have been proposed in the literature to describe the compressive behaviour of FRP confined concrete under both monotonic and cyclic loads.However,the efect of a stress/strain level in the columns has not been well defined because of the lack of well-defined strategies of modeing and oversimplification of the model.This paper reviews the existing FRP combinations and the available numerical and analytical methods to determine the effectiveness of the adopted method.An effort has been made to examine the usage of FRP materials in column applications in exist-ing building regimes and highlights the possible future scopes to improve the use of FRP confined concrete in civil applications. | Mahdi Hosseini Bingyu Jian Haitao Li Dong Yang Ziang Wang Zixian Feng Feng Shen Jian Zhang Rodolfo Lorenzo Ileana Corbi Ottavia Corbi | 2022 | Journal of Renewable Materials2022，10，12： | 1 |
| 10 | Serrated flow in magnesium alloy AZ91显示文摘 | CORBY C CACERES C H LUKAC P | 2004 | Material Science and Engineering A2004，38，： | 1 |
| 11 | Longitudinal analysis of heritability for dental caries traits 显示文摘 | Bretz W A Corby P M Schork N J | 2005 | Dent Res2005，84，11： | 1 |
| 12 | Integrins:ICAMs and selectin:role and regulation of adhesion molecules in neutrophil recruitment to inflammatory sites显示文摘 | Kishimoto TK Larson RS Corbi AL | 1994 | Adv pharmacol1994，25，： | 1 |
| 13 | Intrathecal methotrexate 显示文摘 | Baum ES Koch HF Corby DG | 1971 | Lancet1971，1，7700： | 1 |
| 14 | Architecture analysis of a river flood-dominated delta during an overall sea-level rise (early Pliocene, SE Spain) 显示文摘 | GARCfA-GARCA F CORBI H SORIA J M | 2011 | Sedimentary Geology2011，237，12： | 1 |
| 15 | Heavy metals contents in agricultural topsoils in the Ebro basin(Spain)显示文摘 | Martin JAR Arias ML Corbi JMG | 2006 | Environmental Pollution2006，144，3： | 1 |
| 16 | Secondary tricuspid regurgitation or dilatation: which should be the criteria for surgical repair? 显示文摘 | Dreyfus GD Corbi PJ Chan KM | 2005 | Ann Thorac Surg2005，79，1： | 1 |
| 17 | Building and searching an XML-based corporate memory显示文摘 | Dieng R Corby O | 2000 | IEEE Intelligent Systems2000，15，3： | 1 |
| 18 | A new chestnut显示文摘 | Corby K | 2003 | The Atlantic Monthly2003，291，5： | 1 |
| 19 | Inflammatory response associated with cardiopulmonary bypass and effect of methylprednisolon 显示文摘 | Rshmati M Lecron JC | 2001 | J Thorac cardiovasc Surg2001，122，5： | 1 |
| 20 | Searching the semantic web: approximate query processing based on ontologies显示文摘 | Corby O Dieng-Kuntz R | 2006 | IEEE Intelligent Systems2006，21，1： | 1 |
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