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| 1 | Narrow-band imaging with magnifying endoscopy is accurate for detecting gastric intestinal metaplasia显示文摘AIM:To investigate the predictive value of narrowband imaging with magnifying endoscopy (NBI-ME) for identifying gastric intestinal metaplasia (GIM) in unselected patients. METHODS:We prospectively evaluated consecutive patients undergoing upper endoscopy for various indications, such as epigastric discomfort/pain, anaemia, gastro-oesophageal reflux disease, suspicion of peptic ulcer disease, or chronic liver diseases. Patients underwent NBI-ME, which was performed by three blinded, experienced endoscopists. In addition, five biopsies (2 antrum, 1 angulus, and 2 corpus) were taken and examined by two pathologists unaware of the endoscopic findings to determine the presence or absence of GIM. The correlation between light blue crest (LBC) appearance and histology was measured. Moreover, we quantified the degree of LBC appearance as less than 20% (+), 20%-80% (++) and more than 80% (+++) of an image field, and the semiquantitative evaluation of LBC appearance was correlated with IM percentage from the histological findings. RESULTS:We enrolled 100 (58 F/42 M) patients who were mainly referred for gastro-esophageal reflux disease/dyspepsia (46%), cancer screening/anaemia (34%), chronic liver disease (9%), and suspected celiac disease (6%); the remaining patients were referred for other indications. The prevalence of Helicobacter pylori (H. pylori ) infection detected from the biopsies was 31%, while 67% of the patients used proton pump inhibitors. LBCs were found in the antrum of 33 patients (33%); 20 of the cases were classified as LBC+, 9 as LBC++, and 4 as LBC+++. LBCs were found in the gastric body of 6 patients (6%), with 5 of them also having LBCs in the antrum. The correlation between the appearance of LBCs and histological GIM was good, with a sensitivity of 80% (95%CI:67-92), a specificity of 96% (95%CI:93-99), a positive predictive value of 84% (95%CI:73-96), a negative predictive value of 95% (95%CI:92-98), and an accuracy of 93% (95%CI:90-97). The NBI-ME examination overlooked GIM in 8 cases, but the GIM was less than 5% in 7 of the cases. Moreover, in the 6 false positive cases, the histological examination showed the presence of reactive gastropathy (4 cases) or H. pylori active chronic gastritis (2 cases). The semiquantitative correlation between the rate of LBC appearance and the percentage of GIM was 79% (P < 0.01). CONCLUSION:NBI-ME achieved good sensitivity and specificity in recognising GIM in an unselected population. In routine clinical practice, this technique can reliably target gastric biopsies. | Edoardo Savarino Marina Corbo Pietro Dulbecco Lorenzo Gemignani Elisa Giambruno Luca Mastracci Federica Grillo Vincenzo Savarino | 2013 | World Journal of Gastroenterology2013，19，17： | 23 |
| 2 | Leukocyte telomere length and plasma interleukin-1β and interleukin-18 levels in mild cognitive impairment and Alzheimer's disease: new biomarkers for diagnosis and disease progression?显示文摘Alzheimer's disease and mild cognitive impairment biomarkers: Alzheimer's disease(AD) is a progressive neurodegenerative disease of advancing age.It affects around 47 million people in the world and the number is estimated to increase to 152 million by 2050.Someone develops dementia every three seconds and the current annual cost of dementia is estimated at US $1 trillion, a figure set to double by 2030(Alzheimer's Disease International, 2019). | Rosa Maria Corbo Rita Businaro Daniela Scarabino | 2021 | Neural Regeneration Research2021，16，7： | 3 |
| 3 | Profiling mTOR pathway in neuroendocrine tumors显示文摘 | S. Cingarlini M. Bonomi V. Corbo A. Scarpa G. Tortora | 2012 | Targeted Oncology2012，，3： | 2 |
| 4 | Assessment of Value and Applications of In Vitro Testing of Topical Dermatological Drug Products显示文摘 | Gordon L. Flynn Vinod P. Shah Srinivas N. Tenjarla Michael Corbo David DeMagistris Terry G. Feldman Thomas J. Franz Deborah R. Miran David M. Pearce Joel A. Sequeira James Swarbrick Jonas C. T. Wang Avaraham Yacobi Joel L. Zatz | 1999 | Pharmaceutical Research1999，，9： | 2 |
| 5 | Oxidation behaviour of ledeburitic steels for hot rolls显示文摘 | A Molinari G Straffelini A Tomasi A Biggi G Corbo | 2000 | Materials Science & Engineering A2000，，2： | 2 |
| 6 | The Pricing of Manufactured Goods during Trade Liberalization: Evidence from Chile, Israel, and Korea显示文摘 | Corbo Vittorio and McNelis Paul D | 1989 | The Review of Economics and Statistics1989，，3： | 1 |
| 7 | Microbiological and biochemical characteristics of Canestrato Pugliese cheese made from raw milk, pasteurized milk or by heating the curd in hot whey显示文摘 | ALBENZIO M CORBO M R REHMAN S U | 2001 | Int J good Microblol2001，67，1： | 1 |
| 8 | Use of a copper electrode in alkaline medium as an amperometric sensor for sulphite in a flow-through configuration显示文摘 | Corbo D Bertotti M | 2002 | Anal And Bioanal Chem2002，374，3： | 1 |
| 9 | Size versus shape differences:contrasting voxel-based and volumetric analyses of the anterior cingulate cortex in individuals with acute posttraumatic stress disorder显示文摘 | Corbo V Clement MH Armony JL | 2005 | Biol Psychiatry2005，58，2： | 1 |
| 10 | Use of natural antimicrobials and high pressure homogenization to control the growth of Saccharomyces bayanus in apple juice显示文摘 | Bevilacqua A Corbo M R Sinigaglia M | 2012 | Food Control2012，24，： | 1 |
| 11 | Beta-Glucuronidase(GUS) transposons for ecological and genetic studies of rhizobia and other gram-negative bacteria显示文摘 | Wilson K J Sessitsch A Corbo J C | 1995 | Microbiology1995，141，7： | 1 |
| 12 | In vivo suppression of Bcl-xL expression facilitates chemotherapy-induced leukaemia cell death in a SCID/NOD-Hu model显示文摘 | Fennell DA Corbo MV Dean NM | 2001 | Br J Haematol2001，112，3： | 1 |
| 13 | Snoring in 9- to 15- year-old children: risk factors and clinical relevance 显示文摘 | Corbo GM Forastiere F Agabiti N | 2001 | Pediat- ties2001，108，5： | 1 |
| 14 | Beta- Glucuronidase (GUS)transposons for ecological and genetic studies of rhizobia and other gram- negative bacteria 显示文摘 | Wilson K J Sessitsch A Corbo J C | 1995 | Microbiology1995，141，7： | 1 |
| 15 | Snoring in 9-to 15- year-old children: risk factors and clinical relevance 显示文摘 | Corbo GM Forastiere F Agabiti N | 2001 | Pediatrics2001，108，5： | 1 |
| 16 | Relationships between plasma CoQ10 levels and thyroid hormones in chronic obstructive pulmonary disease显示文摘 | Maneini A Corbo GM Gaballo A | 2005 | Biolactors2005，25，14： | 1 |
| 17 | Snoring in children:association with respiratory symptoms and passive smoking显示文摘 | Corbo GM Fuciarelli F Foresi A | 1989 | BMJ1989，299，： | 1 |
| 18 | In vivo suppression of Bcl-XL expression facilitates chemotherapy-induced leukaemia cell death in a SCID/NOD-Hu model显示文摘 | Fennell DA Corbo MV Dean NM | 2001 | Br J Haematol2001，112，3： | 1 |
| 19 | Nonnutritive sucking during heel stick procedures decreases behavioral distress in the newborn infant显示文摘 | Corbo MG Mansi G Stagni A | 2000 | Biol Neon2000，77，： | 1 |
| 20 | Encapsulation of probiotic bacteria in lamb rennet paste: Effects on the quality of Pecorino cheese显示文摘 | A. Santillo M. Albenzio A. Bevilacqua M.R. Corbo A. Sevi | 2012 | Journal of Dairy Science2012，，7： | 1 |
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