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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Prevention of ventilator associated pneumonia:Current practice in Canadian intensive care units显示文摘 | Heyland D K Cook D J Dodek P M | 2002 | J Crit Care2002，17，3： | 1 |
| 3 | The pathogenesis of turkey rhinotracheitis virus in turkey poults inoculate with the virus alone or together with two stains of bacteria显示文摘 | Cook J K A Ellis M M Huggins M B | 1991 | Avian Pathol1991，20，： | 1 |
| 4 | Aromas of rosemary and lavender essential oils differentially affect cognition and mood in healthy adults显示文摘 | Moss M Cook J wesnes K | | 0，，01： | 1 |
| 5 | Effects of T-2 mycotoxin on gastrointestinal tissues : a review of in vivo and in vitro models 显示文摘 | WORRELL N R MALLETT A K COOK W M | 1989 | Environ Toxicol1989，18，1： | 1 |
| 6 | Multiplex real-time reverse transcription PCR assay for determination of hepatitis C virus genotypes显示文摘 | Cook L Sullivan K Krantz E M | 2006 | J Clin Microbiol2006，44，： | 1 |
| 7 | Rela- tionship between sequence variation in the S1 spike protein of infectious bronchitis virus and the extent of cross-protection in vivo显示文摘 | CAVANAGH D ELUS M M COOK J K | 1997 | Avian Pathol1997，26，1： | 1 |
| 8 | Prediction of headcut migration using a deterministic approach 显示文摘 | HANSON G J ROBINSON K M COOK K R | 2001 | Transactions of the ASAE2001，44，3： | 1 |
| 9 | Stability and Thresholds in some Age - structured Epidemics 显示文摘 | Busenberg S Cooke K Iannelli M | 1989 | Springer Lecture Notes in Biomathematics1989，81，： | 1 |
| 10 | Micromarrows- three-dimensional coculture of hematopoietic stem cells and mesenchymal stromal cells显示文摘 | Cook M M Futrega K Osiecki M | 2012 | Tissue Eng Part C Methods2012，18，5： | 1 |
| 11 | Retention of nitrogen, phosphorus and silicon in a large semi-arid riverine lake system 显示文摘 | Pert'an L Cook M Aldridge K T | 2010 | Biogeochemistry2010，99，13： | 1 |
| 12 | Locoweed poison ing in livestock显示文摘 | Cook D Ralphs M H Welch K D | 2009 | Soci Ran Manage2009，，2： | 1 |
| 13 | Aromas of rosemary and lavender essential oils differentially affect cognition and mood in healthy adults显示文摘 | Moss M Cook J Wesnes K | 2003 | Int J Neurosci2003，113，1： | 1 |
| 14 | Effects of synthetic and naturally occurring flavonoids on metabolic activation of benzopyrene in hamster embryo cell cultures显示文摘 | CHAE Y H HO D K CASSADY J M COOK V M MARCUS C B BAIRD W M | 1992 | Chemico-biological Interactions1992，82，2： | 1 |
| 15 | Betaine in sub- acute and sub-chronic rat studies显示文摘 | HAYES K C PRONCZUK A COOK M W | 2003 | Food Chem Toxicol2003，41，12： | 1 |
| 16 | Large-scale analysis of the human and mouse rranscriptomes显示文摘 | SU A I COOKE M P CHING K A | 2002 | Proc Natl Acad Sci USA2002，99，7： | 1 |
| 17 | Asian monsoon failure and megadrought during the last millennium显示文摘 | Cook E R Anchukaitis K J Buckley B M | 2010 | Science2010，328，5977： | 1 |
| 18 | Asian monsoon failure and megadrought during the last millennium 显示文摘 | Cook E R Anchukaitis K J Buckley B M | | Science0，328，5977： | 1 |
| 19 | The effect of Cu, Zn and Pb on the chlorophyll content of the lichens Cladonia convoluta and Cladonia rangiformis 显示文摘 | Chettri M K Cook C M Vardaka E | 1998 | Environ- mental and Experimental Botany1998，39，1： | 1 |
| 20 | Relative lability of gold-oxide thin films in contact with air, solvents, or electrolyte solutions 显示文摘 | COOK K M FERGUSON G S | 2013 | Journal of Vacuum Science Technology A2013，31，021508： | 1 |
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