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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Anticancer activity of a new compound from Camptotheca acuminata显示文摘 | WALL M E WANI M C COOK C E | 1966 | J Am Chem Soc1966，88，： | 1 |
| 3 | Examination of the melatonin hypothesis in women exposed at night to EMF or bright light显示文摘 | GRAHAM C COOK M R GERKOVICH M M | 2001 | Environ Health Perspect2001，109，5： | 1 |
| 4 | Immune modulation by altered nutrient metabolism:nutritional control of immune-induced growth depression显示文摘 | Cook M E Miller C C Park Y | 1993 | Poult-Sci1993，72，： | 1 |
| 5 | Arthroscopic verification of ultrasonographic diagnosis of meniscal pathology in dogs显示文摘 | Mahn M M Cook J L Cook C R | 2005 | Vet Surg2005，34，4： | 1 |
| 6 | The deglacial history of surface and intermediate water of the Bering Sea显示文摘 | Cook M S Keigwin L D Sancetta C A | 2005 | Deep-Sea Research IT2005，52，： | 1 |
| 7 | Birkhead revised:petrological and geochemical studies of the Birkhead formation, Eromanga Basin显示文摘 | Smyth M Cook A C Philp R P | 1984 | APEA1984，24，1： | 1 |
| 8 | Estimating paleorecharge and paleoclimate from unsaturated zone profiles显示文摘 | COOK P G EDMUNDS W M GAYE C B | 1992 | Water Resources Research1992，28，： | 1 |
| 9 | The reversible reduction of disulfide bonds in polyalanyl ribonuclease 显示文摘 | ANFINSEN C B SELA M COOKE J P | 1962 | J Biol Chem1962，237，： | 1 |
| 10 | Users' perceptions of library service quality: a LibQUAL + qualitative study显示文摘 | Cook C Heath F M | 2001 | Library Trends2001，49，4： | 1 |
| 11 | Plant Antitutor Agent I:The isolation and structure of camptothecin,a novel alkaloidal Leukemia and tumor inhibitor from Camptotheca acuminate显示文摘 | Wall M E Wani M C Cook C E | 1966 | J Amer Chem Soc1966，88，16： | 1 |
| 12 | Interelemental relationship in the soil and plant tissue and photosynthesis of field cultivated wheat growing in naturally enriched copper soils 显示文摘 | Vardaka E Cook C M Lanaras T | 1997 | Journal of Plant Nutrition1997，20，1： | 1 |
| 13 | Effects of synthetic and naturally occurring flavonoids on metabolic activation of benzopyrene in hamster embryo cell cultures显示文摘 | CHAE Y H HO D K CASSADY J M COOK V M MARCUS C B BAIRD W M | 1992 | Chemico-biological Interactions1992，82，2： | 1 |
| 14 | Betaine in sub- acute and sub-chronic rat studies显示文摘 | HAYES K C PRONCZUK A COOK M W | 2003 | Food Chem Toxicol2003，41，12： | 1 |
| 15 | The inner centro- mere protein (INCENP) antigens: movement from inner een- tromere to midbody during mitosis显示文摘 | Cooke C A Heck M M Earnshaw W C | 1987 | J Cell Biol1987，105，5： | 1 |
| 16 | Di- ameter dependent radial and tangential elastic moduli of ZnO nanowires 显示文摘 | Stan G Ciobanu C V Parthangal P M Cook R F | 2007 | Nano Letters2007，7，12： | 1 |
| 17 | Immune modulation by altered nutrient metabolism: nutritional control of immune-induced growth depression显示文摘 | Cook M E Miller C C Park Y | 1993 | Poult Sci1993，72，： | 1 |
| 18 | Users' perceptions of Library Service Quality: A LibQUALt qualitative study 显示文摘 | Cook C Heath F M | 2001 | Library Trends2001，49，4： | 1 |
| 19 | Interelemental relationship in the soil and plant tissue and photosynthesis of field cultivated wheat growing in naturally enriched copper soils显示文摘 | Vardake E Cook C M Lanaras T | 1997 | J Plant Nutr1997，20，45： | 1 |
| 20 | The underwater sound generated by heavy rainfall显示文摘 | Nystuen J A McGlothin C Cook M | | 0，，06： | 1 |
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