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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Postoperative morbidity and mortality after D1 and D2 resections for gastric cancer: preliminary results of the MRC randomised controlled surgical trial显示文摘 | A Cuschieri V Joypaul P Fayers P Cook J Fielding J Craven J Bancewicz | 1996 | The Lancet . 1996 (9007)1996，，： | 2 |
| 3 | Short term evaluation of carbon coated and uncoated porous titanium implants clin显示文摘 | COOK S D HADDAD R J | 1989 | Clin Mater1989，4，： | 1 |
| 4 | Software process validation:quantitatively measuring the correspondence of a process to a model显示文摘 | WOLF A L | 1999 | ACM Transactions on Software Engineering and Methodology1999，8，2： | 1 |
| 5 | Diurnal variations in hydraulic conductivity and root pressure can be correlated with the expression of putative aquaporlns in the roots of Lotus japonicus显示文摘 | HENZLER T WATERHOUSE R N SMYTH A J CARVAJAL M COOKE D T SCHAFFNER A R STEUDLE E CLARKSOND T | 1999 | Planta1999，210，： | 1 |
| 6 | The pathogenesis of turkey rhinotracheitis virus in turkey poults inoculate with the virus alone or together with two stains of bacteria显示文摘 | Cook J K A Ellis M M Huggins M B | 1991 | Avian Pathol1991，20，： | 1 |
| 7 | An arbitrary Lagrangian-Eulerian computing method for all flow speeds 显示文摘 | Hirt G W Amsden A A Cook J L | 1974 | J Comp Phys1974，14，3： | 1 |
| 8 | Nutritional value of dietary nucleic acids to trout显示文摘 | Tacon A G J Cooke D J | 1980 | Nutr Rep Int1980，22，： | 1 |
| 9 | An arbitrary Lagrangian- Eulerian computing method for all flow speeds 显示文摘 | Hirt C W Amsden A A Cook J L | 1997 | Journal of Computational Physics1997，135，2： | 1 |
| 10 | National Ignition Facility target design and fabrication显示文摘 | COOK R C KOZIOZIEMSKI B J NIKROO A | 2008 | Laser and Particle Beams2008，26，3： | 1 |
| 11 | Nitric oxide regula- tion of gonadotrophin seeretion in prepubertal heifers显示文摘 | Honaramooz A Cook S J Beard A P et ol | 1999 | J Neu- roendoerinol1999，11，9： | 1 |
| 12 | From rural single- county to muhicounty regional transit systems: Benefits of consolidation显示文摘 | Cook T J J J Lawrie A J Henry | 2003 | Transportation Research Record2003，，1841： | 1 |
| 13 | A methodology for the as- sessment of unconventional(continuous) resources with an ap- plication to the Greater Natural Buttes Gas Field, Utah显示文摘 | Olea R A Cook T A Coleman J L | 2010 | Natural Resources Research2010，19，4： | 1 |
| 14 | The behavior of bearings used for seismic isolation under shear and axial load 显示文摘 | P J Moss N Cook A J Carr | 1999 | Earthquake Spectra1999，15，2： | 1 |
| 15 | The values of ternary quadratic forms at prime arguments显示文摘 | Cook R J Fox A | 2001 | Mathematika2001，48，： | 1 |
| 16 | Flame retardance and shrinkage reduction of polystyrene modified with amylate - con-taining phosphorus and crosslinkable spiro -orthoester moieties 显示文摘 | CANADELL J HUNT B J COOK A G | 2007 | Polymer Degradation and Stability2007，92，8： | 1 |
| 17 | Solvent forpaclitaxel,and toxicity显示文摘 | LIEBMANN J COOK J A MITCHELL J B | 1993 | Lancet1993，342，8884： | 1 |
| 18 | A recombinant fowlpox virus that expresses the VP2 antigen of infectious bursal disease virus induces protection against mortality caused by the virus显示文摘 | BAYLISS C D PETERS R W COOK J K A | 1991 | Arch Virol1991，120，： | 1 |
| 19 | The clinical signifcance of serum transferring receptor levels in sickle cell disease显示文摘 | Singhal A Cook J D Sikne B S | 1993 | Br J Haematol1993，84，： | 1 |
| 20 | Simultaneous axial and rotational electron beam velocity measurement using a phosphor scintillator显示文摘 | He W Cooke S J Cross A W | 2001 | Review of Scientific Instruments2001，72，5： | 1 |
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