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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | An arbitrary Lagrangian- Eulerian computing method for all flow speeds 显示文摘 | Hirt C W Amsden A A Cook J L | 1997 | Journal of Computational Physics1997，135，2： | 1 |
| 3 | National Ignition Facility target design and fabrication显示文摘 | COOK R C KOZIOZIEMSKI B J NIKROO A | 2008 | Laser and Particle Beams2008，26，3： | 1 |
| 4 | Biodiversity and the tourism value of Changbai Mountain Biosphere Reserve, China: A travel cost approach 显示文摘 | Xue D Cook A Tisdell C | 2000 | Tourism Economics2000，6，4： | 1 |
| 5 | A recombinant fowlpox virus that expresses the VP2 antigen of infectious bursal disease virus induces protection against mortality caused by the virus显示文摘 | BAYLISS C D PETERS R W COOK J K A | 1991 | Arch Virol1991，120，： | 1 |
| 6 | The deglacial history of surface and intermediate water of the Bering Sea显示文摘 | Cook M S Keigwin L D Sancetta C A | 2005 | Deep-Sea Research IT2005，52，： | 1 |
| 7 | Isolation of Resistance Gene Candidates (RGCs) and characterization of an RGC cluster in cassava显示文摘 | Lopez C E Zuluaga A P Cooke R | 2003 | Molecular Genetics and Genomics2003，269，5： | 1 |
| 8 | Relationship between serum mullerian-inhibiting substance and other reproductive hormones in untreated women with polycystic ovary syndrome and normal women显示文摘 | Cook C L Siow Y Brenner A G | 2002 | Fertility and Sterility2002，77，1： | 1 |
| 9 | Birkhead revised:petrological and geochemical studies of the Birkhead formation, Eromanga Basin显示文摘 | Smyth M Cook A C Philp R P | 1984 | APEA1984，24，1： | 1 |
| 10 | Survey of veterinary practitioners on PMWS and PDNS in the UK显示文摘 | Gresham A Cook A J C Thomson J R | 2003 | Veterinary Record2003，153，13： | 1 |
| 11 | An arbitrary Lagrangian-Eulerian computing method for all flow speeds显示文摘 | Hirt C W Amsden A A Cook H K | 1974 | J Comput Phys1974，14，： | 1 |
| 12 | Analysis of the human type I insulin - like growth factor receptor promoter region 显示文摘 | Cooke D W Bankert L A Roberts C T Jr | 1991 | Biochemical and Biophysical Research Communications1991，177，3： | 1 |
| 13 | Factors influencing bond strength of adhesive anchors显示文摘 | Cook Ronald A Konz Robert C | 2001 | ACI Structural Journal2001，98，： | 1 |
| 14 | Betaine in sub- acute and sub-chronic rat studies显示文摘 | HAYES K C PRONCZUK A COOK M W | 2003 | Food Chem Toxicol2003，41，12： | 1 |
| 15 | The inner centro- mere protein (INCENP) antigens: movement from inner een- tromere to midbody during mitosis显示文摘 | Cooke C A Heck M M Earnshaw W C | 1987 | J Cell Biol1987，105，5： | 1 |
| 16 | Self-processing 2A polyproteins-a system for co-ordinate expression of multiple pro teins in transgenic plants显示文摘 | Halpin C Cooke S E Barakate A | 1999 | J The Plant Joural1999，17，4： | 1 |
| 17 | Phosphorylation of histone H3 at serine 10 is correlated with chromosome condensation during mitosis and meiosis in Tetrahymena显示文摘 | Wei Y Mizzen C A Cook R G | 1998 | Proc Natl Acad Sci USA1998，95，： | 1 |
| 18 | The mechanisms of the formation and growth of water bubbles and associated dislocation loops in synthetic quartz显示文摘 | McLaren A C Cook R F Hyde S T | 1983 | Phys Chem Mineral1983，9，： | 1 |
| 19 | Supported ionic liquid eataly- sis-a new concept for homogeneous hydroformylation ca- talysls 显示文摘 | Mehnert C P Cook R A | 2002 | J Am Chem Soc2002，124，12： | 1 |
| 20 | Effect of partial middle turbinectomy on nasal airflow and resistance 显示文摘 | COOK P R BEGEGNI A BRYANT W C | 1995 | Otolaryngol Head Neck Surg1995，113，： | 1 |
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