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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | 向在人的察觉到钙的受体的 allosteric 药的结构的理解显示文摘allosterically 指向人的察觉到钙的受体(CaSR ) 的药有实质的治疗学的潜力,但是当前被限制。给 CaSR 的高分辨率的结构的缺席,我们把 mutagenesis 与一条新奇分析途径并且开发 “ 的分子的建模相结合; enriched”为在 Ca 2+ 在 CaSRs 7 transmembrane (7TM ) 以内的 o 和 allosteric 调节的人领域。修改多重有约束力的地点以适应在结构上的一个扩大的洞多样的 ligands 被识别。Phenylalkylamines 绑在与通常认为的 Ca 2+ o -binding 地点并且向一个细胞外的门厅延长。相反,在结构上和 pharmacologically 不同的 AC-265347 在 7TM 领域以内更深绑。而且,不同氨基酸网络被发现调停由不同调节的人的 cooperativity。这些调查结果可以与不同、潜在地偏导小径的药理学效果便于 allosteric 调节的人的合理设计。 | Katie Leach Karen J Gregory Irina Kufareva Elham Khajehali Anna E Cook Ruben Abagyan Arthur D Conigrave Patrick M Sexton Arthur Christopoulos | 2016 | Cell Research2016，26，5： | 2 |
| 3 | Prevention of ventilator associated pneumonia:Current practice in Canadian intensive care units显示文摘 | Heyland D K Cook D J Dodek P M | 2002 | J Crit Care2002，17，3： | 1 |
| 4 | Diurnal variations in hydraulic conductivity and root pressure can be correlated with the expression of putative aquaporlns in the roots of Lotus japonicus显示文摘 | HENZLER T WATERHOUSE R N SMYTH A J CARVAJAL M COOKE D T SCHAFFNER A R STEUDLE E CLARKSOND T | 1999 | Planta1999，210，： | 1 |
| 5 | The pathogenesis of turkey rhinotracheitis virus in turkey poults inoculate with the virus alone or together with two stains of bacteria显示文摘 | Cook J K A Ellis M M Huggins M B | 1991 | Avian Pathol1991，20，： | 1 |
| 6 | Arthroscopic verification of ultrasonographic diagnosis of meniscal pathology in dogs显示文摘 | Mahn M M Cook J L Cook C R | 2005 | Vet Surg2005，34，4： | 1 |
| 7 | Archive,records,and power:the making of modern memory显示文摘 | Schwartz J M Cook T | 2002 | Archival Science2002，2，12： | 1 |
| 8 | Recognizing speech under a processing load:Dissociatting energetic from informational factors显示文摘 | Mattys S L Brooks J Cooke M | | 0，，03： | 1 |
| 9 | Aromas of rosemary and lavender essential oils differentially affect cognition and mood in healthy adults显示文摘 | Moss M Cook J wesnes K | | 0，，01： | 1 |
| 10 | Nonhuman primate models of stroke for translational neuroprotection research显示文摘 | Cook D J Tymianski M | 2012 | Neurotherapeuties2012，9，2： | 1 |
| 11 | Tetanus显示文摘 | Farrar J J Yen L M Cook T | 2000 | J Neurol Neurosurg Psychiatry2000，69，： | 1 |
| 12 | Construction and testing of micmsatellite database containing more than 500 tomoto varieties 显示文摘 | BREDEMEIJER G M M COOK R J GANAL M W | 2002 | Theor Appl Genet2002，105，： | 1 |
| 13 | Geological and geochemical characteristics of the Sawaya'erdun gold deposit, southwestern Chinese Tianshan显示文摘 | Liu J J Zheng M H Cook N J | 2007 | Ore Geology Reviews2007，32，： | 1 |
| 14 | CFD modelling of natural displacement ventilation in an enclosure connected to an atrium显示文摘 | JI Y COOK M J HANBY V | 2007 | Building and Environment2007，42，3： | 1 |
| 15 | Decomposition of gear vibration signals by the generalized S transform 显示文摘 | Mefadden P D Cook J G Forster L M | 1999 | Mechanical Systems and Signal Processing1999，13，5： | 1 |
| 16 | Phylogenetic analysis of Phytophthora species based on ITS1 and ITS2 sequences of the ribosomal RNA gene repeat显示文摘 | Cooke D E L Duncan J M | 1997 | Mycological Research1997，101，： | 1 |
| 17 | Rela- tionship between sequence variation in the S1 spike protein of infectious bronchitis virus and the extent of cross-protection in vivo显示文摘 | CAVANAGH D ELUS M M COOK J K | 1997 | Avian Pathol1997，26，1： | 1 |
| 18 | The ProSeal laryngeal mask airway: a review of the literature显示文摘 | COOK T M LEE G NOLAN J P | 2005 | Can J Anaesth2005，52，7： | 1 |
| 19 | The aetiology, consequences and prevention of barotrauma: a critical review of the literature 显示文摘 | Meade M O Cook D J | 1995 | Clin Intensive Care1995，6，4： | 1 |
| 20 | Assessment of the uniformity of wheat and tomato varieties at DNA microsatel- lite loci 显示文摘 | Cooke R J Bredemeijer G M M Ganal M W el al | 2003 | 132 : 33 ! -3412003，132，： | 1 |
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