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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Interactive High-Dimensional Data Visualization 显示文摘 | Buja A Cook D Swayne D F | 1996 | Journal of Computational and Graphical Statistics1996，5，1： | 2 |
| 3 | Interactive high-dimensional data visualization显示文摘 | BUJA A COOK D SWAYNE D | 1996 | Journal of Computational and Graphical Statistics1996，5，： | 1 |
| 4 | Short term evaluation of carbon coated and uncoated porous titanium implants clin显示文摘 | COOK S D HADDAD R J | 1989 | Clin Mater1989，4，： | 1 |
| 5 | Fibroblast growth factor, epidermal growth factor, and platelet derived growth factor-BB stimulate proliferation of clonally derived porcine myogenic satellite cells显示文摘 | Doumit M E Cook D R Merkel R A | 1993 | J Cell Physiol1993，157，： | 1 |
| 6 | Diurnal variations in hydraulic conductivity and root pressure can be correlated with the expression of putative aquaporlns in the roots of Lotus japonicus显示文摘 | HENZLER T WATERHOUSE R N SMYTH A J CARVAJAL M COOKE D T SCHAFFNER A R STEUDLE E CLARKSOND T | 1999 | Planta1999，210，： | 1 |
| 7 | Nutritional value of dietary nucleic acids to trout显示文摘 | Tacon A G J Cooke D J | 1980 | Nutr Rep Int1980，22，： | 1 |
| 8 | Shock Tube Studies of Methane and Ethane Oxidation 显示文摘 | Cooke D F Williams A | 1975 | Combustion and Flame1975，24，： | 1 |
| 9 | Biodiversity and the tourism value of Changbai Mountain Biosphere Reserve, China: A travel cost approach 显示文摘 | Xue D Cook A Tisdell C | 2000 | Tourism Economics2000，6，4： | 1 |
| 10 | A recombinant fowlpox virus that expresses the VP2 antigen of infectious bursal disease virus induces protection against mortality caused by the virus显示文摘 | BAYLISS C D PETERS R W COOK J K A | 1991 | Arch Virol1991，120，： | 1 |
| 11 | The clinical signifcance of serum transferring receptor levels in sickle cell disease显示文摘 | Singhal A Cook J D Sikne B S | 1993 | Br J Haematol1993，84，： | 1 |
| 12 | Thermal volatile generation in barley malt: on-line MS studies显示文摘 | CHANNELL G A YAI-IYA I-I COOK D J | 2010 | J Am Soc Brew Chern2010，68，4： | 1 |
| 13 | The deglacial history of surface and intermediate water of the Bering Sea显示文摘 | Cook M S Keigwin L D Sancetta C A | 2005 | Deep-Sea Research IT2005，52，： | 1 |
| 14 | paihogenesis of venous ulceration in relation to the calt muscle pump function显示文摘 | Christopoulos D Nicolaioles AN cook A | 1989 | sugery1989，，： | 1 |
| 15 | Inflammation and type one diabetes显示文摘 | Bending D Zaccone P Cooke A | | 0，，06： | 1 |
| 16 | Generalized linear inversion of reflection seismic data显示文摘 | COOKE D A SCHNEIDER WA | 1983 | Geophysics1983，48，6： | 1 |
| 17 | Nuclear Level Densities in Intermediate and Heavy Nuclei显示文摘 | COOK J L FERGUSON H MUSGROVE A R D | 1967 | Australian Journal of Physics1967，20，： | 1 |
| 18 | A molecular phylogeny of Phytophthora and related oomycetes显示文摘 | COOKE D E L DRENTH A DUNCAN J M | 2000 | Fungal Genetics and Biology2000，30，： | 1 |
| 19 | Analysis of the human type I insulin - like growth factor receptor promoter region 显示文摘 | Cooke D W Bankert L A Roberts C T Jr | 1991 | Biochemical and Biophysical Research Communications1991，177，3： | 1 |
| 20 | Population-based evaluation of type-specific HPV prevalence among women in British Columbia,Canada显示文摘 | OGILVIE G S COOK D A TAYLOR D L | 2013 | Vaccine2013，31，： | 1 |
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