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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Anticancer activity of a new compound from Camptotheca acuminata显示文摘 | WALL M E WANI M C COOK C E | 1966 | J Am Chem Soc1966，88，： | 1 |
| 3 | Immune modulation by altered nutrient metabolism:nutritional control of immune-induced growth depression显示文摘 | Cook M E Miller C C Park Y | 1993 | Poult-Sci1993，72，： | 1 |
| 4 | Structure of chlorotrifluoroethylene/vinylidene fluoride Random copolymers and homopolymers by molecular dynamics simulations显示文摘 | Gee R H Fried L E Cook R C | 2001 | Macromolecules2001，34，： | 1 |
| 5 | Atmospheric Corrosion of Different Steels in Marine, Rural and Industrial Environments 显示文摘 | Oh S J Cook D C Townsend H E | 1999 | Corrosion Science1999，41，3： | 1 |
| 6 | The deuterium to hydrogen ratios of sap in trees: implications for water sources and tree ring deuterium to hydrogen ratios显示文摘 | White J W C Cook E R Lawrence J R | 1985 | Geochimica Et Cosmochimiea Aeta1985，49，： | 1 |
| 7 | Isolation of Resistance Gene Candidates (RGCs) and characterization of an RGC cluster in cassava显示文摘 | Lopez C E Zuluaga A P Cooke R | 2003 | Molecular Genetics and Genomics2003，269，5： | 1 |
| 8 | Plant Antitutor Agent I:The isolation and structure of camptothecin,a novel alkaloidal Leukemia and tumor inhibitor from Camptotheca acuminate显示文摘 | Wall M E Wani M C Cook C E | 1966 | J Amer Chem Soc1966，88，16： | 1 |
| 9 | Interelemental relationship in the soil and plant tissue and photosynthesis of field cultivated wheat growing in naturally enriched copper soils 显示文摘 | Vardaka E Cook C M Lanaras T | 1997 | Journal of Plant Nutrition1997，20，1： | 1 |
| 10 | Electroencephalographic quantitation of opioid effect:Comparative pharmacodynamics of fentanyl and sufentanil显示文摘 | SCOTT J C COOKE J E STANSKI D R | 1991 | Anesthesiology1991，74，1： | 1 |
| 11 | A synthetic oestrus- exciting compound显示文摘 | Cook J W Dodds E C Hewtt C L | 1933 | Nature1933，131，： | 1 |
| 12 | Immune modulation by altered nutrient metabolism: nutritional control of immune-induced growth depression显示文摘 | Cook M E Miller C C Park Y | 1993 | Poult Sci1993，72，： | 1 |
| 13 | Atmospheric Corrosion of Different Steels in Marine, Rural and Industrial Environments 显示文摘 | Oh S J Cook D C Townsend H E | 1999 | Corrosion Scienee1999，41，9： | 1 |
| 14 | Self-processing 2A polyproteins-a system for co-ordinate expression of multiple pro teins in transgenic plants显示文摘 | Halpin C Cooke S E Barakate A | 1999 | J The Plant Joural1999，17，4： | 1 |
| 15 | Testing computer-controlled infusion pumps by simulation显示文摘 | SHAFER S L SIEGEL L C COOKE J E | 1988 | Anesthesiology1988，68，26： | 1 |
| 16 | Effect of Fracturing on Fracture Conductivity 显示文摘 | Cook C E | 1975 | JPT1975，10，： | 1 |
| 17 | MMR vaccination and pervasive developmental disorders: a case-control study显示文摘 | Smeeth L Cook C Fombonne E | 2004 | Lancet2004，364，： | 1 |
| 18 | Interelemental relationship in the soil and plant tissue and photosynthesis of field cultivated wheat growing in naturally enriched copper soils显示文摘 | Vardake E Cook C M Lanaras T | 1997 | J Plant Nutr1997，20，45： | 1 |
| 19 | Atmospheric cor rosion of different steels in marine, rural and industri al environments 显示文摘 | Sei J O Cook D C Townsend H E | 1999 | Corrosion Science1999，，： | 1 |
| 20 | The effect of Cu, Zn and Pb on the chlorophyll content of the lichens Cladonia convoluta and Cladonia rangiformis 显示文摘 | Chettri M K Cook C M Vardaka E | 1998 | Environ- mental and Experimental Botany1998，39，1： | 1 |
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