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| 1 | Management of nonalcoholic fatty liver disease:An evidence-based clinical practice review显示文摘AIM:To build a consensus among Chilean specialists on the appropriate management of patients with nonalcoholic fatty liver disease(NAFLD)in clinical practice.METHODS:NAFLD has now reached epidemic proportions worldwide.The optimal treatment for NAFLD has not been established due to a lack of evidence-based recommendations.An expert panel of members of the Chilean Gastroenterological Society and the Chilean Hepatology Association conducted a structured analysis of the current literature on NAFLD therapy.The quality of the evidence and the level of recommendations supporting each statement were assessed according to the recommendations of the United States Preventive Services Task Force.A modified three-round Delphi technique was used to reach a consensus among the experts.RESULTS:A group of thirteen experts was established.The survey included 17 open-ended questions that were distributed among the experts,who assessed the articles associated with each question.The levels of agreement achieved by the panel were 93.8%in the first round and 100%in the second and third rounds.The final recommendations support the indication of lifestyle changes,including diet and exercise,for all patients with NAFLD.Proven pharmacological therapies include only vitamin E and pioglitazone,which can be used in nondiabetic patients with biopsy-proven nonalcoholic steatohepatitis(the progressive form of NAFLD),although the long-term safety and efficacy of these therapies have not yet been established.CONCLUSION:Current NAFLD management is rapidly evolving,and new pathophysiology-based therapies are expected to be introduced in the near future.All NAFLD patients should be evaluated using a three-focused approach that considers the risks of liver disease,diabetes and cardiovascular events. | Juan P Arab Roberto Candia Rodrigo Zapata Cristián Mu?oz Juan P Arancibia Jaime Poniachik Alejandro Soza Francisco Fuster Javier Brahm Edgar Sanhueza Jorge Contreras M Carolina Cuellar Marco Arrese Arnoldo Riquelme | 2014 | World Journal of Gastroenterology2014，20，34： | 11 |
| 2 | Therapeutic alternatives for the treatment of type 1 hepatorenal syndrome: A Delphi technique-based consensus显示文摘AIM To propose several alternatives treatment of type 1 hepatorenal syndrome(HRS-1) what is the most severe expression of circulatory dysfunction on patients with portal hypertension.METHODS A group of eleven gastroenterologists and nephrologists performed a structured analysis of available literature.Each expert was designated to review and answer a question.They generated draft statements for evaluation by all the experts.Additional input was obtained from medical community.In order to reach consensus,a modified three-round Delphi technique method was used.According to United States Preventive Services Task Force criteria,the quality of the evidence and level of recommendation supporting each statement was graded.RESULTS Nine questions were formulated.The available evidence was evaluated considering its quality,number of patients included in the studies and the consistency of its results.The generated questions were answered by the expert panel with a high level of agreement.Thus,a therapeutic algorithm was generated.The role of terlipressin and norepinephrine was confirmed as the pharmacologic treatment of choice.On the other hand the use of the combination of octreotide,midodrine and albumin without vasoconstrictors was discouraged.The role of several other options was also evaluated and the available evidence was explored and discussed.Liver transplantation is considered the definitive treatment for HRS-1.The present consensus is an important effort that intends to organize the available strategies based on the available evidence in the literature,the quality of the evidence and the benefits,adverse effects and availability of the therapeutic tools described.CONCLUSION Based on the available evidence the expert panel was able to discriminate the most appropriate therapeutic alternatives for the treatment of HRS-1. | Juan P Arab Juan C Claro Juan P Arancibia Jorge Contreras Fernando Gomez Cristian Munoz Leyla Nazal Eric Roessler Rodrigo Wolff Marco Arrese Carlos Benítez | 2016 | World Journal of Hepatology2016，8，25： | 3 |
| 3 | Optical and crystallization behavior of TiO2 and V/TiO2 thin films prepared by plasma and ion beam assisted methods显示文摘 | Holgado J P Contreras L | 2003 | Thin Solid films2003，429，12： | 1 |
| 4 | Sorption of 2,4-dichlorophenol on modified hydrotalcites 显示文摘 | Klumpp E Contreras 0 C Klahre P | 2003 | Colloids and SurfacesA : Physicochemical Engineering Aspects2003，230，123： | 1 |
| 5 | Heart rate variability as early marker of multiple organ dysfunction syndrome in septic patients显示文摘 | Pontet J Contreras P Curbelo A | 2003 | J Crit Care2003，18，3： | 1 |
| 6 | Chronic caregiver stress and IgE expression,allergen-induced proliferation,and cytokine profiles in a birth cohort predisposed to atopy显示文摘 | Wright RJ Finn P Contreras JP Cohen S Wright RO Staudenmayer J | | 0，，： | 1 |
| 7 | Hypercapnic acidosis attenuates pulmonary epithelial wound repair by an NF-κB dependent mechanism显示文摘 | O′Toole D Hassett P Contreras M | 2009 | Thorax2009，64，： | 1 |
| 8 | Comp arison between an in vitro method to determine carbohydrate digestion rate and the gly- caemic response in young men 显示文摘 | Araya H Contreras P Alvina M | 2002 | European Journal of Clinical Nutrition2002，56，： | 1 |
| 9 | Elevated extracellular glucose and uncontrolled type 1 diabetes enhance NFAT5 signaling and disrupt the transverse tubular network in mouse skeletal muscle 显示文摘 | Hemandez-Ochoa EO Robison P Contreras M | 2012 | Exp Biol Med( Maywood)2012，237，9： | 1 |
| 10 | Field and laboratoryselection of Frankliniella occidentalis (Pergande) for resistance to insecticides显示文摘 | Espinosa P J Bielza P Contreras J | 2002 | Pest Management Science2002，58，9： | 1 |
| 11 | A general model of rift basin evolution : constraints of first order stratigraphic observations 显示文摘 | Contreras J Scholz C H King G C P | 1997 | Journal of Geophysical Research1997，102，： | 1 |
| 12 | Characterization and catalytic activity of CoMo HDS catalysts supported on alumina-MCM-41显示文摘 | RAMIREZ J CONTRERAS R CASTILLO P | 2000 | Appl Catal: A2000，197，1： | 1 |
| 13 | Bluetongue virus: virology, pathogenesis and immunity显示文摘 | Schwarta-Cornil I Mertens P P Contreras V | 2008 | Veterinary Research2008，39，5： | 1 |
| 14 | Haem O and a putative eytochrome bo in a mutant of Bacillus cereus impaired in the synthesis of haem a 显示文摘 | Del Arenal I P Contreras M L Svlateorova B B | 1997 | Archives of Microbiology1997，167，1： | 1 |
| 15 | Levels of amino acid neurotransmitters during mouse cerebellar neurogensis and in histostypic cerebellar cultures显示文摘 | Miranda Contreras L Benitez Diaz P R Mendoza Briceno R V | 1999 | Dev Neurosci1999，21，2： | 1 |
| 16 | Multi-fed power electronic transformer for use in modern distribution systems显示文摘 | Contreras J P Ramirez J M | 2014 | IEEE Transactions on Smart Grid2014，，5： | 1 |
| 17 | Role of electrohydraulic extracorporeal shockwave lithotripsy(Dornier HM 4)in the treatment of caliceal diverticulum lithiasis显示文摘 | Torrecilla O C Marco P L Contreras G J | 1998 | Actas Urol Esp1998，22，9： | 1 |
| 18 | A comparison between an in vitro method to determine carbohydrate digestion rate and the glycemic response in young men 显示文摘 | Araya H Contreras P Alvina M | 2002 | European Journal of Clinical Nutrition2002，56，： | 1 |
| 19 | Evaluation of quantitative cultures ofendotracheal aspirates for pediatric ventilator - ssociatedpneumonia diagnosis : analytic,prospective study 显示文摘 | Contreras P Milet B Coria P | 2011 | Rev Chilerralixfectol2011，28，4： | 1 |
| 20 | UV and UV/Fe(Ⅲ) - enhanced ozonation of nitrobenzene 显示文摘 | Contreras S P odrl'guez M Chamarro E | 2001 | J Photochem Photobiol A2001，142，： | 1 |
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