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| 1 | Treatment of chronic hepatitis C with direct-acting antivirals: The role of resistance显示文摘The use of direct-acting antivirals(DAAs) to treat chronic hepatitis C has resulted in a significant increase in rates of sustained viral response(around 90%-95%) as compared with the standard treatment of peginterferon/ribavirin. Despite this, however, the rates of therapeutic failure in daily clinical practice range from 10%-15%. Most of these cases are due to the presence of resistant viral variants, resulting from mutations produced by substitutions of amino acids in the viral target protein that reduce viral sensitivity to DAAs, thus limiting the efficacy of these drugs. The high genetic diversity of hepatitis C virus has resulted in the existence of resistance-associated variants(RAVs), sometimes even before starting treatment with DAAs, though generally at low levels. These preexisting RAVs do not appear to impact on the sustained viral response, whereas those that appear after DAA therapy could well be determinant in virological failure with future treatments. As well as the presence of RAVs, virological failure to treatment with DAAs is generally associated with other factors related with a poor response, such as the degree of fibrosis, the response to previous therapy, the viral load or the viral genotype. Nonetheless, viral breakthrough and relapse can still occur in the absence of detectable RAVs and after the use of highly effective DAAs, so that the true clinical impact of the presence of RAVs in therapeutic failure remains to be determined. | Miguel Jiménez-Pérez Rocío González-Grande Pilar Espana Contreras Isabel Pinazo Martínez Jesús de la Cruz Lombardo Raúl Olmedo Martín | 2016 | World Journal of Gastroenterology2016，22，29： | 3 |
| 2 | Friction-stir welding of a beryllium-aluminum powder metallurgy alloy显示文摘 | CONTRERAS F TRILLO E A MURR L E | 2002 | Journal of materials science2002，37，： | 1 |
| 3 | Optical and crystallization behavior of TiO2 and V/TiO2 thin films prepared by plasma and ion beam assisted methods显示文摘 | Holgado J P Contreras L | 2003 | Thin Solid films2003，429，12： | 1 |
| 4 | Arsenic interactions during co-combustion processes based on thermodynamic equilibrium calculations显示文摘 | CONTRERAS M L AROSTEGUI J M ARMESTO L | 2009 | Fuel2009，88，3： | 1 |
| 5 | Gas chromatographic determination of pesticides in vegetable samples by sequential positive and negative chemical ionization and tandem mass spectrometric fragmentation using an ion trap analyzer显示文摘 | Hemando M D Aguera A Fernandez-Alba A R Piedra L Contreras M | | 0，，： | 1 |
| 6 | Pharmacokinetics of inhaled rifampicin porous particles for tuberculosis treatment: insight into rifampicin absorption from the lungs of guinea pigs显示文摘 | Garcia Contreras L Sung J Ibrahim M | 2015 | Mol Pharrn2015，12，8： | 1 |
| 7 | Differential responses to copper-induced oxidative stress in the marine macroalgae Lessonia nigrescens and Scytosiphon lomentaria (Phaeophyeeae) 显示文摘 | Contreras L Mella D Moenne A | 2009 | Aquatic Toxicology2009，94，2： | 1 |
| 8 | Wettability and spreading kinetics of AI and Mg on TiC显示文摘 | Contreras A Leon C A Drew R A L | 2003 | Scripta Materialia2003，48，： | 1 |
| 9 | Intelligent multi-Agent support for the contingency management system 显示文摘 | SHEREMETOV L B CONTRERAS M VALENCIA C | 2004 | Expert Systems with Applications2004，26，1： | 1 |
| 10 | Developmem and validation of a method for the simultaneous extraction and separate measurement of oxytetracycline, florfenicol, oxolinic acid and flumequine from marine sediments 显示文摘 | NORAMBUENA L GRAS N CONTRERAS S | 2013 | Marine Pollu- tion Bulletin2013，73，1： | 1 |
| 11 | Habitat loss and population decline: A meta-analysis of the patch size effect显示文摘 | Bender D J Contreras T A Fahring L | 1998 | Ecology1998，79，2： | 1 |
| 12 | Estimation of the actual bubble surface area flux in flotation 显示文摘 | J Leiva L Vinnett F Contreras | 2010 | Minerals Engineering2010，23，： | 1 |
| 13 | Patterns of electromyo- graphic activity in subjects with different sleletal facial types显示文摘 | Miralles R Hevia R Contreras L | 1991 | Angel Orthod1991，61，： | 1 |
| 14 | Mutational analysis of the hormone-sensitive lipase transloeation reaction in adipocytes显示文摘 | Su C L Sztalryd C Contreras J A | 2003 | J Biol Chem2003，278，43： | 1 |
| 15 | Haem O and a putative eytochrome bo in a mutant of Bacillus cereus impaired in the synthesis of haem a 显示文摘 | Del Arenal I P Contreras M L Svlateorova B B | 1997 | Archives of Microbiology1997，167，1： | 1 |
| 16 | Integrating Simulation Modeling and Equipment Condition Diagnostics for Predictive Maintenance Strategies-a Case Study显示文摘 | CONTRERAS L R MODI C PENNATHUR A | 2002 | Proceedings of the 2002 Winter Simulation Conference2002，10，： | 1 |
| 17 | Levels of amino acid neurotransmitters during mouse cerebellar neurogensis and in histostypic cerebellar cultures显示文摘 | Miranda Contreras L Benitez Diaz P R Mendoza Briceno R V | 1999 | Dev Neurosci1999，21，2： | 1 |
| 18 | Fixing FRAND: A Pseudo-Pool Approach To Standards-Based Patent Licensing 显示文摘 | CONTRERAS J L | 2013 | Antitrust Law Journal2013，79，1： | 1 |
| 19 | Halophilic hydrolases as a new tool for the biotechnological industries显示文摘 | Mariana Delgado‐García Blanca Valdivia‐Urdiales Cristóbal Noe Aguilar‐González Juan Carlos Contreras‐Esquivel Raúl Rodríguez‐Herrera | 2012 | J. Sci. Food Agric2012，，13： | 1 |
| 20 | Role of electrohydraulic extracorporeal shockwave lithotripsy(Dornier HM 4)in the treatment of caliceal diverticulum lithiasis显示文摘 | Torrecilla O C Marco P L Contreras G J | 1998 | Actas Urol Esp1998，22，9： | 1 |
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