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| 1 | Capecitabine and cisplatin with or without cetuximab for patients with previously untreated advanced gastric cancer (EXPAND): a randomised, open-label phase 3 trial显示文摘 | Florian Lordick Yoon-Koo Kang Hyun-Cheol Chung Pamela Salman Sang Cheul Oh Gy?rgy Bodoky Galina Kurteva Constantin Volovat Vladimir M Moiseyenko Vera Gorbunova Joon Oh Park Akira Sawaki Ilhan Celik Heiko G?tte Helena Melezínková Markus Moehler | 2013 | Lancet Oncology2013，，6： | 14 |
| 2 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 3 | Effect of bombesin and neurotensin on gut barrier function in partially hepatectomized rats显示文摘AIM: To investigate the effect of regulatory peptides bombesin (BBS) and neurotensin (NT) on intestinal barrier function in partially hepatectomized rats.METHODS: Ninety male Wistar rats were randomly divided into five groups: Ⅰ (n = 10): controls, Ⅱ (n =20): sham operated, Ⅲ (n = 20): partial hepatectomy 70% (PHx), Ⅳ (n = 20): PHx+BBS (30 μg/kg/d), Ⅴ (n= 20): PHx+NT (300 μg/kg/d). Groups Ⅳ and Ⅴ were treated for 8 days before PHx and 48 h post surgery.At the end of the experiment, on day 10, intestinal barrier function was assessed by measuring endotoxin concentrations in portal and aortic blood. Tissue sections of the terminal ileum were examined histologically and villus density, mucosal thickness, mitotic activity and apoptosis in crypts were assessed. In addition, ileal mucosa was analyzed for DNA and protein content and microbiological analysis was performed in cecal contents.To estimate intestinal oxidative stress, lipid peroxidation was determined on tissue homogenates from terminal ileum.RESULTS: BBS or NT administration significantly reduced portal and systemic endotoxemia observed 48 h after partial hepatectomy. In hepatectomized rats (group Ⅲ), a trend towards induction of mucosal atrophy was observed, demonstrated by the reduction of villus density, mucosal thickness, protein content and significant reduction of DNA, while these alterations were reversed by regulatory peptides administration.This trophic effect of BBS and NT was accompanied by induction of mitoses above control levels and a significant reduction of apoptosis in intestinal crypts.Intestinal lipid peroxidation was found significantly lower in PHx group and regulatory peptides exerted an antioxidant action, further decreasing this parameter of oxidative stress. The bacterial population of E. coli and aerobic Gram (+) cocci was increased in cecal content of hepatectomized rats, while this parameter was not affected by the administration of BBS or NT.CONCLUSION: Gut regulatory peptides BBS and NT improve intestinal barrier function and reduce endotoxemia in experimental partial hepatectomy. This effect is, at least in part, mediated by their trophic,antiapoptotic, mitogenic, and antioxidant effect on the intestinal epithelium. This observation might be of potential value in patients undergoing liver resection. | Stelios F Assimakopoulos Ilias H Alexandris Chrisoula D Scopa Panagiotis G Mylonas Konstantinos C Thomopoulos Christos D Georgiou Vassiliki N Nikolopoulou Constantine E Vagianos | 2005 | World Journal of Gastroenterology2005，11，43： | 8 |
| 4 | Splenic arteriovenous fistula and sudden onset of portal hypertension as complications of a ruptured splenic artery aneurysm: Successful treatment with transcatheter arterial embolization. A case study and review of the literature显示文摘为不平常却记录得好的享受的脾的动静脉瘘(SAVF ) 报道门静脉高血压的有能力的原因([1-4 ]) 。突然由于 SAVF 形成开发了门静脉高血压的 50 岁的经产的女性的一个盒子被介绍。受不了的病人在过去的 12 天期间重复了 haematemesis 和 melaena 的事件,因此, emer 轻轻地为管理进入医院。临床并且实验室调查当肝实质的不在时建立了门静脉高血压的诊断疾病。内视镜检查法揭示了多重食道的流血静脉曲张。腹的计算断层摄影术(CT ) 和 transfemoral 腹的动脉 X 线摄影法记录了一根曲折、动脉瘤的脾的动脉并且一根扩大脾的静脉的早熟的充满的存在, SAVF 高度暗示的调查结果。上述的脉管的反常成功地与经皮的 transcatheter embolization 被对待。既不复发也不其它复杂并发症被观察。 | Dimitrios Siablis Zafiria G Papathanassiou Dimitrios Karnabatidis Nikolaos Christeas Konstantinos Katsanos Constantine Vagianos | 2006 | World Journal of Gastroenterology2006，12，26： | 6 |
| 5 | Athens Insomnia Scale: validation of an instrument based on ICD-10 criteria显示文摘 | Constantin R Soldatos Dimitris G Dikeos Thomas J Paparrigopoulos | 2000 | Journal of Psychosomatic Research2000，，6： | 2 |
| 6 | An IT view on perspectives of computer aided process planning research 显示文摘 | Faruk G Constantin C | 1997 | Computer in Industry1997，129，： | 1 |
| 7 | Ion chromatographic method for the simultaneous determination of nitrite and nitrate by post-column indirect fluorescence detection 显示文摘 | CONSTANTINE D S CONSTANTINA N K CHRISTOS G N | 2003 | Journal of Chromatography A2003，1002，： | 1 |
| 8 | Frictional characteristics of teflon-steel interfaces under dynamic conditions显示文摘 | Constantinou M C Caccese J Harris H G | 1987 | Earthquake Engineering and Structural Dynamics1987，15，6： | 1 |
| 9 | Virus-induced gene silencing as a tool for functional genomics in a legume species显示文摘 | CONSTANTIN G | 2004 | Plant J2004，40，： | 1 |
| 10 | Black smoker chimney fragments in Cyprus sulphide deposits 显示文摘 | Oudin E Constantinou G | 1984 | Nature1984，308，： | 1 |
| 11 | Safety of repair for severe duodenal injuries显示文摘 | Velmahos GC Constantinou C Kasotakis G | 2008 | World J Surg2008，32，1： | 1 |
| 12 | University-in- dustry knowledge transfer and network patterns in romania: does knowledge supply fit SMEs' regional profiles? 显示文摘 | Serbanica C M Constantin D L Dragan G | 2015 | European Planning Studies2015，23，2： | 1 |
| 13 | Role of MRI in clinical cardiology 显示文摘 | Constantine G Shan K Flamm S D | 2004 | Lancet2004，363，9427： | 1 |
| 14 | Role of cardiac magnetic resonance imaging in the assessment of myocardial viability显示文摘 | Shan K Constantine G Sivananthan M | 2004 | Circulation2004，109，11： | 1 |
| 15 | Role of cardiac magnetic resonance imaging in the assessment of myocardial viability显示文摘 | Shan K Constantine G Sivananthan M | 2004 | Circulation2004，109，3： | 1 |
| 16 | Ion chromatographic method for the simultaneous determination of nitrite and nitrate by post-column indirect fluorescence de- tection显示文摘 | CONSTANTINE D S CONSTANTINA N K CHRISTOS G N | 2003 | J Chromatogr A2003，100，2： | 1 |
| 17 | Age-associated leukoaraiosis and cortical cholinergic deafferentation显示文摘 | N I. Bohnen M L.T.M. Müller H Kuwabara G M. Constantine S A. Studenski | 2009 | Neurology2009，，16： | 1 |
| 18 | Satiety of repair for severe duodenal injuries显示文摘 | Velmahos GC Constantinous C Kasotaikis G | 2008 | World J Surg2008，32，1： | 1 |
| 19 | Dynamic analysis of generalized viscoelastic fluids显示文摘 | Makris N Dargush G F Constantinous M C | 1993 | Journal of Structural Engi- neering1993，119，8： | 1 |
| 20 | Design,construction and calibration of a three axis,high-frequency magnetic probe(B-dot probe) as a diagnostic for exploding plasmas显示文摘 | Everson E T Pribyl P Constantin C G | | 0，，： | 1 |
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