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| 1 | Effect of bombesin and neurotensin on gut barrier function in partially hepatectomized rats显示文摘AIM: To investigate the effect of regulatory peptides bombesin (BBS) and neurotensin (NT) on intestinal barrier function in partially hepatectomized rats.METHODS: Ninety male Wistar rats were randomly divided into five groups: Ⅰ (n = 10): controls, Ⅱ (n =20): sham operated, Ⅲ (n = 20): partial hepatectomy 70% (PHx), Ⅳ (n = 20): PHx+BBS (30 μg/kg/d), Ⅴ (n= 20): PHx+NT (300 μg/kg/d). Groups Ⅳ and Ⅴ were treated for 8 days before PHx and 48 h post surgery.At the end of the experiment, on day 10, intestinal barrier function was assessed by measuring endotoxin concentrations in portal and aortic blood. Tissue sections of the terminal ileum were examined histologically and villus density, mucosal thickness, mitotic activity and apoptosis in crypts were assessed. In addition, ileal mucosa was analyzed for DNA and protein content and microbiological analysis was performed in cecal contents.To estimate intestinal oxidative stress, lipid peroxidation was determined on tissue homogenates from terminal ileum.RESULTS: BBS or NT administration significantly reduced portal and systemic endotoxemia observed 48 h after partial hepatectomy. In hepatectomized rats (group Ⅲ), a trend towards induction of mucosal atrophy was observed, demonstrated by the reduction of villus density, mucosal thickness, protein content and significant reduction of DNA, while these alterations were reversed by regulatory peptides administration.This trophic effect of BBS and NT was accompanied by induction of mitoses above control levels and a significant reduction of apoptosis in intestinal crypts.Intestinal lipid peroxidation was found significantly lower in PHx group and regulatory peptides exerted an antioxidant action, further decreasing this parameter of oxidative stress. The bacterial population of E. coli and aerobic Gram (+) cocci was increased in cecal content of hepatectomized rats, while this parameter was not affected by the administration of BBS or NT.CONCLUSION: Gut regulatory peptides BBS and NT improve intestinal barrier function and reduce endotoxemia in experimental partial hepatectomy. This effect is, at least in part, mediated by their trophic,antiapoptotic, mitogenic, and antioxidant effect on the intestinal epithelium. This observation might be of potential value in patients undergoing liver resection. | Stelios F Assimakopoulos Ilias H Alexandris Chrisoula D Scopa Panagiotis G Mylonas Konstantinos C Thomopoulos Christos D Georgiou Vassiliki N Nikolopoulou Constantine E Vagianos | 2005 | World Journal of Gastroenterology2005，11，43： | 8 |
| 2 | 22-gauge core vs 22-gauge aspiration needle for endoscopic ultrasound-guided sampling of abdominal masses显示文摘AIM To compare the aspiration needle(AN) and core biopsy needle(PC) in endoscopic ultrasound-guided fine needle aspiration(EUS-FNA) of abdominal masses.METHODS Consecutive patients referred for EUS-FNA were included in this prospective single-center trial. Each patient underwent a puncture of the lesion with both standard 22-gauge(G) AN(Echo Tip Ultra; Cook Medical, Bloomington, Indiana, United States) and the novel 22 G PC(Echo Tip Pro Core; Cook Medical, Bloomington, Indiana, United States) in a randomized fashion; histology was attempted in the PC group only. The main study endpoint was the overall diagnostic accuracy, including the contribution of histology to the final diagnosis. Secondary outcome measures included material adequacy, number of needle passes, and complications.RESULTS Fifty six consecutive patients(29 men; mean age 68 years) with pancreatic lesions(n = 38), lymphadenopathy(n = 13), submucosal tumors(n = 4), or others lesions(n = 1) underwent EUS-FNA using both of the needles in a randomized order. AN and PC reached similar overall results for diagnostic accuracy(AN: 88.9 vs PC: 96.1, P = 0.25), specimen adequacy(AN: 96.4% vs PC: 91.1%, P = 0.38), mean number of passes(AN: 1.5 vs PC: 1.7, P = 0.14), mean cellularity score(AN: 1.7 vs PC: 1.1, P = 0.058), and complications(none). A diagnosis on the basis of histology was achieved in the PC group in 36(64.3%) patients, and in 2 of those as the sole modality. In patients with available histology the mean cellularity score was higher for AN(AN: 1.7 vs PC: 1.0, P = 0.034); no other differences were of statistical significance.CONCLUSION Both needles achieved high overall diagnostic yields and similar performance characteristics for cytological diagnosis; histological analysis was only possible in 2/3 of cases with the new needle. | William Sterlacci Athanasios D Sioulas Lothar Veits Pervin G?nüllü Guido Schachschal Stefan Groth Mario Anders Christos K Kontos Theodoros Topalidis Andrea Hinsch Michael Vieth Thomas R?sch Ulrike W Denzer | 2016 | World Journal of Gastroenterology2016，22，39： | 2 |
| 3 | Ion chromatographic method for the simultaneous determination of nitrite and nitrate by post-column indirect fluorescence detection 显示文摘 | CONSTANTINE D S CONSTANTINA N K CHRISTOS G N | 2003 | Journal of Chromatography A2003，1002，： | 1 |
| 4 | Ion chromatographic method for the simultaneous determination of nitrite and nitrate by post-column indirect fluorescence de- tection显示文摘 | CONSTANTINE D S CONSTANTINA N K CHRISTOS G N | 2003 | J Chromatogr A2003，100，2： | 1 |
| 5 | Ion chromatographic method for the simultaneous determination of nitrite and nitrate by post - column indirect fluorescence detection 显示文摘 | Constantine D Constantina N Christos G | 2003 | J Chromatogr A2003，1002，12： | 1 |
| 6 | Acute combined effects of olive oil and wine on pressure wave reflections: another beneficial influence of the Mediterranean diet antioxidants?显示文摘 | Christos M Papamichael Kalliopi N Karatzi Theodore G Papaioannou Emmanouil N Karatzis Paraskevi Katsichti Vasilis Sideris Nikolaos Zakopoulos Antonis Zampelas John P Lekakis | 2008 | Journal of Hypertension2008，，2： | 1 |
| 7 | Unusual radiological finding of lethal pneumatosis intestinalis and portomesenteric vein gas显示文摘Pneumatosis intestinalis and portomesenteric vein gas are rare and potentially severe radiological findings that occur both in pediatric and adult populations.They actually are radiographic signs of underlying intra-abdominal pathology,abnormality or diagnostic medical interference.If combined with other radiological or clinical signs of intestinal ischemia or sepsis,the prognosis is dismal and urgent laparotomy is mandatory.We report two cases of surgical treatment with ominous outcome in an effort to characterize this finding correctly as an absolute surgical indication or as an additional diagnostic criterion that simply marks a further breakdown of the systems in patients with a long list of severe medical conditions. | Ioannis D Kyriazanos Theodoros A Bazinas Grigorios G Tsoukalos Christos N Stoidis | 2010 | World Journal of Radiology2010，2，6： | 1 |
| 8 | A cyber- physical experimentation environment for the security analysis of networked industrial control systems 显示文摘 | BILA G CHRISTOS S IGOR N F | 2012 | Computers and Electrical Engineering2012，38，5： | 1 |
| 9 | A survey of large-scale analytical query processing in MapReduce显示文摘 | Christos Doulkeridis Kjetil N?rv?g | 2014 | The VLDB Journal2014，，3： | 1 |
| 10 | Efficient search based on content similarity over self-organizing P2P networks显示文摘 | Christos Doulkeridis Akrivi Vlachou Kjetil N?rv?g Yannis Kotidis Michalis Vazirgiannis | 2010 | Peer - to - Peer Networking and Applications2010，，1： | 1 |
| 11 | Statistical analysis and simulation of indoor single-phase low voltage power-line communication channels on the basis of multi-path propagation 显示文摘 | Ioannis C Papaleonidopoulos Christos N Capasalis Constantinos G Karagiannopolos | 2003 | IEEE Transaction on Consumer Electronics2003，49，1： | 1 |
| 12 | Influence of grain type on the susceptibility of different Sitophilus oryzae (L) populations,obtained from different rearing media,to three diatomaceous earth formulations显示文摘 | Christos G A Kavallieratos N G Vayias B J | 2008 | Journal of Stored Products Research2008，44，3： | 1 |
| 13 | Context-based caching and routing for P2P web service discovery显示文摘 | Christos Doulkeridis Vassilis Zafeiris Kjetil N?rv?g Michalis Vazirgiannis Emmanouel A. Giakoumakis | 2007 | Distributed and Parallel Databases2007，，1： | 1 |
| 14 | TNF-α Induction by LPS Is Regulated Posttranscriptionally via a Tpl2/ERK-Dependent Pathway显示文摘 | Calin D Dumitru Jeffrey D Ceci Christos Tsatsanis Dimitris Kontoyiannis Konstantinos Stamatakis Jun-Hsiang Lin Christos Patriotis Nancy A Jenkins Neal G Copeland George Kollias Philip N Tsichlis | 2000 | Cell2000，，7： | 1 |
| 15 | Splenic abscess in a patient with fecal peritonitis显示文摘Splenic abscess is a rare entity normally associated with underlying diseases.We report a case of splenic abscess with large gas formation in a non-diabetic and non-immunosuppressed patient after surgery for colon perforation.The most frequent cause of splenic abscess is septic embolism arising from bacterial endocarditis.Splenic abscess has a high rate of mortality when it is diagnosed late.Computed tomography resolved any diagnostic doubt,and subsequent surgery confirmed the diagnosis. | Spiros G Delis Petros N Maniatis Charikleia Triantopoulou John Papailiou Christos Dervenis | 2007 | World Journal of Gastroenterology2007，13，10： | 0 |
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