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| 1 | MELD score,insulin-like growth factor 1 and cytokines on bone density in end-stage liver disease显示文摘AIM:To determine the contributions of insulin-like growth factor 1 (IGF-1),cytokines and liver disease severity to bone mineral density in patients pre-transplantation.METHODS:Serum IGF-1,tumor necrosis factor-α (TNFα) and interleukin 6 (IL-6) were measured and the Model for End-Stage Liver Disease (MELD) score calculated in 121 adult patients referred to a single centre for liver transplantation.Bone mineral density (BMD) of the lumbar spine and femoral neck were assessed via dual energy X-ray absorptiometry.Demographics,liver disease etiology,medication use and relevant biochemistry were recorded.RESULTS:A total of 117 subjects were included,with low BMD seen in 68.6%,irrespective of disease etiol-ogy.In multivariable analysis,low body mass index (BMI),increased bone turnover and low IGF-1 were independent predictors of low spinal bone density.At the hip,BMI,IGF-1 and vitamin D status were predictive.Despite prevalent elevations of TNFα and IL-6,levels did not correlate with degree of bone loss.The MELD score failed to predict low BMD in this pre-transplant population.CONCLUSION:Osteopenia/osteoporosis is common in advanced liver disease.Low serum IGF-1 is weakly predictive but serum cytokine and MELD score fail to predict the severity of bone disease. | Rebecca Mitchell Jill McDermid Mang M Ma Constance L Chik | 2011 | World Journal of Hepatology2011，3，6： | 5 |
| 2 | Effect of nonylphenol on serum testosterone levels and testicular steroidogenie enzyme activity in neonatal,pubertal, and adult rats显示文摘 | ELIZABETH M L GANESH B CONSTANCE W | 2002 | Chemico-Biological Interactions2002，139，1： | 1 |
| 3 | Adolescents'ideas about individual-agency cultures显示文摘 | Constance Flanagan | 2001 | International Journal of Behavioral Development2001，25，1： | 1 |
| 4 | Elevated serum cardiac troponin I in older patients with hip fracture: in cidence and prognostic signifieance显示文摘 | Sylvain A Vincent M Constance M | 2008 | Arch Orthop Traum Su2008，128，7： | 1 |
| 5 | Systematic review:the evidence that publishing patient care performance data improves quality of care显示文摘 | Constance H F Lim Y W Soeren M | 2008 | Ann Intern Med2008，148，2： | 1 |
| 6 | The revised FLACC observational pain tool: Improved reliability and validity for pain assessment in children with cognitive impairment 显示文摘 | Shobha M Terri VL Constance B | 2006 | Pediatric Anesthesia2006，16，： | 1 |
| 7 | Carotenoid database of commonly eaten Swiss vegetables and their estimated contribution to carotenoid intake显示文摘 | Constance Reif Eva Arrigoni Hans Sch?rer Laura Nystr?m Richard F. Hurrell | 2013 | Journal of Food Composition and Analysis2013，，1： | 1 |
| 8 | Uses and challenges of novel compounds for plant disease control显示文摘 | Lodovica G M Leroux P Constance M S | 2000 | Crop Protection2000，19，： | 1 |
| 9 | Bcl-2 protects against hyperoxia-induced apoptosis through inhibition of the mitochondria-dependent pathway显示文摘 | Isabelle Métrailler-Ruchonnet Alessandra Pagano Stephanie Carnesecchi Christiane Ody Yves Donati Constance Barazzone Argiroffo | 2007 | Free Radical Biology and Medicine2007，，： | 1 |
| 10 | Osteochondro repair sing perichondrial cells显示文摘 | Constance RC Dounchis JS Yoshioka M | 1997 | Clin Orthop1997，340，： | 1 |
| 11 | Novel inhibitors of matrix metalloproteinase gene expression as potential therapies for arthritis显示文摘 | Mix Kimberlee S K S Sporn Michael B M B Brinckerhoff Constance E C E etal | 2004 | Clin OrthopRelat Res2004，427，1： | 1 |
| 12 | C-myc inactivation by mutant Max alters growth and morphology of NCI-H-630 colon cancer cells显示文摘 | Aldo B Constance M Cultraro | 1996 | J Cell Physiol1996，169，3： | 1 |
| 13 | Amino acid constituents of ristocetin A 显示文摘 | Harris Constance M Kibby Jeffrey J | 1979 | Journal of the American Chemical Society1979，，2： | 1 |
| 14 | Holmes treating opportunistic infections among HIV-infected adults and adolescent 显示文摘 | CONSTANCE A B JONATHAN E K HENTY M | 2004 | MMWR Recornm Rep2004，53，15： | 1 |
| 15 | Crx , a Novel otx -like Homeobox Gene, Shows Photoreceptor-Specific Expression and Regulates Photoreceptor Differentiation显示文摘 | Takahisa Furukawa Eric M Morrow Constance L Cepko | 1997 | Cell1997，，4： | 1 |
| 16 | C/EBPa regulation of the growth-arrest-associated gene gadd45显示文摘 | Constance C M Morgan J I Umek R M | 1996 | Mol Cell Biol1996，16，： | 1 |
| 17 | Novel inhibitors of matrix metalloproteinase gene expression as potential therapies for arthritis显示文摘 | Mix Kimberlee S K S Sporn Michael B M B Brinckerhoff Constance E C E | | 0，，427： | 1 |
| 18 | Cross-reactive IgE antibody responses to tropomyosins from Ascaris lumbricoides and cockroach显示文摘 | Ana Beatriz R. Santos Gutemberg M. Rocha Constance Oliver Virgínia P.L. Ferriani Rodrigo C. Lima Mário S. Palma Valéria S.F. Sales Rob C. Aalberse Martin D. Chapman L. Karla Arruda | 2008 | The Journal of Allergy and Clinical Immunology2008，，4： | 1 |
| 19 | Preparative separation of isomeric sulfophthalic acids by conventional and pH-zone-refining counter-current chromatography显示文摘 | Adrian W Eugene P M Constance M | 2002 | J Chromatogr2002，966，： | 1 |
| 20 | Articular cartilage repair using allogeneic perichondrocyte-seeded biodegradable porous pollactic acid (PLA):a tissue engineering study 显示文摘 | Constance RC Coutts RD Yoshika M | 1995 | J Biomed Mater Res1995，29，： | 1 |
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