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| 1 | Etiology and long-term outcome of extrahepatic portal vein obstruction in children显示文摘AIM:To study the management and outcome of children with extrahepatic portal vein obstruction(EHPVO) in a whole country population.METHODS:A nationwide multicenter retrospective case series of children with EHPVO was conducted.Data on demographics,radiographic studies,laboratory workup,endoscopic and surgical procedures,growth and development,were extracted from the patients' charts.Characteristics of clinical presentation,etiology of EHPVO,management and outcome were analyzed.RESULTS:Thirty patients,13 males and 17 females,19(63.3%) Israeli and 11(36.7%) Palestinians,were included in the analysis.Age at presentation was 4.8± 4.6 years,and mean follow-up was 4.9±4.3 years.Associated anomalies were found in 4 patients.The incidence of EHPVO in Israeli children aged 0-14 years was 0.72/million.Risk factors for EHPVO were detected in 13(43.3%)patients,including 9 patients(30%) with perinatal risk factors,and 4 patients(13.3%) with prothrombotic states:two had low levels of protein S and C,one had lupus anticoagulant,and one was homozygous for methyltetrahydrofolate reductase mutations.In 56.6% of patients,no predisposing factors were found.The most common presenting symptoms were an incidental finding of splenomegaly(43.3%),and upper gastrointestinal bleeding(40%).No differences were found between Israeli and Palestinian children with regard to age at presentation,etiology and clinical symptoms.Bleeding occurred in 18 patients(60%),at a median age of 3 years.Sclerotherapy or esophageal banding was performed in 20 patients.No sclerotherapy complications were reported.Portosystemic shunts were performed in 11 patients(36.6%),at a median age of 11(range 3-17)years:splenorenal in 9,mesocaval in 1,and a meso-Rex shunt in 1 patient.One patient underwent splenectomy due to severe pancytopenia.Patients were followed up for a median of 3(range 0.5-15)years.One patient died aged 3 years due to mucopolysaccharidase deficiency type Ⅲ.None of the patients died due to gastrointestinal bleeding.CONCLUSION:EHPVO is a rare disorder.The etiological factors are still mostly unknown,and the endoscopic and surgical treatment options ensure a good long-term prognosis. | Batia Weiss Eyal Shteyer Asaf Vivante Drora Berkowitz Shimon Reif Zvi Weizman Yoram Bujanover Rivka Shapiro | 2010 | World Journal of Gastroenterology2010，16，39： | 6 |
| 2 | Neural stem cell proliferation is decreased in schizophrenia, but not in depression 显示文摘 | Reif A Fritzen S Finger M | 2006 | Mol Psychiatry2006，11，5： | 1 |
| 3 | The effect of trace element on refining grain of super pure copper 显示文摘 | | 1993 | Metall German (in German)1993，47，11： | 1 |
| 4 | Drug diffusion in neutral and ionic hydrogels assembled from aeetylated galactoglucomannan 显示文摘 | Voepel J Sjoberg J Reif M | 2009 | Journal of Applied Polymer Science2009，112，4： | 1 |
| 5 | Least squares approximation of Bezier coefficients provides best degree reduction in the Lz-norm显示文摘 | Peters J Reif U | 2000 | Journal of Approximation Theory2000，104，1： | 1 |
| 6 | Differential effect of endothelial nitric oxide synthase (NOS-Ⅲ) on the regulation of adult neurogenesis and behaviour显示文摘 | REIF A SCHMITT A FRITZEN S | 2004 | Eur J Neurosci2004，20，4： | 1 |
| 7 | The role of focal adhesion kinase-phosphatidylinositol 3-kinase-Akt signaling in hepatic stellate cell proliferation and type Ⅰ collagen expression显示文摘 | Reif S Lang A Lindquist JN | 2003 | J Biol Chem2003，278，10： | 1 |
| 8 | Late pregnancy exposures to disinfection by-products and growth-related birth outcomes 显示文摘 | HINCKLEY A F BACHAND A M REIF J S | 2005 | Environ Health Perspect2005，113，12： | 1 |
| 9 | 查看详情显示文摘 | Meyerdierks H Heithausen A Reif K | | 0，，： | 1 |
| 10 | An EKF-based nonlinear observer with a prescribed degree of stability显示文摘 | Sonnemann F Unbehauen R | 1998 | Automatic1998，34，9： | 1 |
| 11 | Procedure to generate thiessen polygons 显示文摘 | Brassel K E Reif D | 1979 | Geographical Analysis1979，，11： | 1 |
| 12 | A self-assembly model of time-dependent glue strength显示文摘 | Sahu S Yin P Reif J H | 2006 | Lecture Notes in Computer Science2006，3892，： | 1 |
| 13 | Practical applications for solidification of metals and alloys under ultrasonic vibrations显示文摘 | Abdel-Rehim M Reif W | 1984 | Metal1984，38，12： | 1 |
| 14 | 1H detected ^1H, ^15N correlation spectroscopy in rotating solids显示文摘 | Reif B Griffin R G | 2003 | J Magn Reson2003，1，： | 1 |
| 15 | Methemoglobinemia induced by lidocaine-prilocaine cream显示文摘 | ShamrizO Cohen-GlickmanI ReifS | 2014 | Isr Med Assoc J2014，16，4： | 1 |
| 16 | Stochastic stability of the discrete-time extended Kalman filter显示文摘 | Reif K Gunther S Yaz E | 1999 | IEEE Transactions on Automatic Control1999，44，4： | 1 |
| 17 | Disease resistance results from foreign phytoulexin expression in a novel plant显示文摘 | Reif H J Krause E | 1993 | Nature1993，361，6408： | 1 |
| 18 | Genetic Distance Based on Simple Sequence Repeats and Heterosis in Tropical Maize Populations显示文摘 | Melchinger A E Xia X C | 2003 | Crop Sci2003，43，4： | 1 |
| 19 | Homocysteinemia as well as methy-lenetetrahydrofolate reductase polymorphism are associated with affective psychoses显示文摘 | Reif A Pfuhlmann B Lesch KP | 2005 | Prog Neuropsychopharmacol Biol Psychiatry2005，29，7： | 1 |
| 20 | Antihypertensive efficacy of candesartan in comparison to losartan: the CLAIM study显示文摘 | Bakris G Gradman A Reif M | 2001 | J Clin Hypertens2001，3，： | 1 |
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