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| 1 | ICC density predicts bacterial overgrowth in a rat model of post-infectious IBS显示文摘AIM:To investigate the interstitial cells of Cajal(ICC) number using a new rat model.METHODS:Sprague-Dawley rats were assigned to two groups.The first group received gavage with Campylobacter jejuni(C.jejuni) 81-176.The second group was gavaged with placebo.Three months after clearance of Campylobacter from the stool,precise segments of duodenum,jejunum,and ileum were ligated in self-contained loops of bowel that were preserved in anaerobic bags.Deep muscular plexus ICC(DMP-ICC) were quantified by two blinded readers assessing the tissue in a random,coded order.The number of ICC per villus was compared among controls,Campylobacter recovered rats without small intestinal bacterial overgrowth(SIBO),and Campylobacter recovered rats with SIBO.RESULTS:Three months after recovery,27% of rats gavaged with C.jejuni had SIBO.The rats with SIBO had a lower number of DMP-ICC than controls in the jejunum and ileum.Additionally there appeared to be a density threshold of 0.12 DMP-ICC/villus that was associated with SIBO.If ileal density of DMP-ICC was < 0.12 ICC/villus,54% of rats had SIBO compared to 9% among ileal sections with > 0.12(P<0.05).If the density of ICC was < 0.12 DMP-ICC/villus in more than one location of the bowel,88% of these had SIBO compared to 6% in those who did not(P<0.001).CONCLUSION:In this post-infectious rat model,the development of SIBO appears to be associated with a reduction in DMP-ICC.Further study of this rat model might help understand the pathophysiology of postinfectious irritable bowel syndrome. | Sam-Ryong Jee Walter Morales Kimberly Low Christopher Chang Amy Zhu Venkata Pokkunuri Soumya Chatterjee Edy Soffer Jeffrey L Conklin Mark Pimentel | 2010 | World Journal of Gastroenterology2010，16，29： | 3 |
| 2 | Genetic evidence for the role of GDP-mannose in plant ascorbic acid biosynthesis显示文摘 | CONKLIN NORRIS S R WHEELER G L | 1999 | PNAS1999，96，： | 1 |
| 3 | Differential accumulation of antioxidant mRNAs in Arabidopsis thaliana exposed to ozone显示文摘 | Conklin P L Last R L | 1995 | Plant Physiol1995，109，： | 1 |
| 4 | Germline transmission of RNAi in mice显示文摘 | Carmell MA Zhang L Conklin DS | 2003 | Nat Struct Biol2003，10，： | 1 |
| 5 | Arabidopsis thaliana VTC4encodes L-galactose-1-P phosphatase,aplant ascorbic acid biosynthetic enzyme显示文摘 | Conklin P L Gatzek S Wheeler G L | 2006 | Journal of Biology Chemistry2006，281，15： | 1 |
| 6 | Biosynthesis of ascorbic acid in plants:a renaissance显示文摘 | Smirnoff N Conklin P L Loewus F A | | 0，，： | 1 |
| 7 | Recent advances in the role and biosynthesis of ascorbic acid in plants显示文摘 | Conklin P L | 2001 | Plant Cell & Environment2001，24，4： | 1 |
| 8 | Germline transmission of RNAi in mice显示文摘 | Carmell MA Zhang L Conklin DS | 2003 | Nat Struct Biol2003，10，3： | 1 |
| 9 | Genetic evidence for the role of GDP-mannose in plant ascorbic acid显示文摘 | Conklin P L Norris S R Wheeler G L | 1999 | Proceedings of the National Academy of Sciences of the United States of Americay 19991999，，： | 1 |
| 10 | gIBIS: A hypertext tool for exploratory policy discussion显示文摘 | Conklin J Begeman M L | 1988 | ACM Transactions on Office Information Systems1988，6，4： | 1 |
| 11 | Development and evaluation of diets for crustacean aquaculture 显示文摘 | Bordner C E D'Abramo L R Conklin D E | 1986 | Jour- nal of the World Aquaculture Society1986，17，14： | 1 |
| 12 | Molecular replacement in cancer therapy: reversing cancer metabolic and mitochondrial dysfunction, fatigure and the adverse effects of cancer therapy 显示文摘 | Nicolson G L Conklin K A | 2008 | Curr Cancer Ther Rev2008，4，1： | 1 |
| 13 | Ascorbic acid,a familiar small molecule intertwined in the response of plants to ozone,pathogens,and the onset of senescence显示文摘 | Conklin P L Barth C | | 0，，： | 1 |
| 14 | Identification of ascorbic acid-deficient Arabidopsis thaliana mutants显示文摘 | Conklin P L Saracco S A Norris S R Last R L | 2000 | Genetics2000，154，： | 1 |
| 15 | Identification of ascorbic acid-deficient Arabidopsis thaliana mutants显示文摘 | Conklin P L Saracco S A Norris S R Last R L | | 0，，： | 1 |
| 16 | Biosynthesis of aseorbie acid in plants : a renaissance 显示文摘 | Smirnoff N Conklin P L Loewus F A | 2001 | Annual review of plant biology2001，52，1： | 1 |
| 17 | Identifica- tion of ascorbic acid-deficient Arabidopsis thalian mutants 显示文摘 | Conklin P L Saracco S A Norris S R | 2000 | Genetics2000，154，2： | 1 |
| 18 | Development and evaluation of a novel decellularized vascular xenograft显示文摘 | CONKLIN B S RICHTER E R KREUTZIGER K L | 2002 | Med Eng Phys2002，24，： | 1 |
| 19 | L-ascorbic acid metabolism in the ascorbate-deficient Arabidopsis mutant vtcl 显示文摘 | Conklin P L Pallanca J E Last R L | 1997 | Plant Physiology1997，115，3： | 1 |
| 20 | Histochemical evaluation of energy metabolism in rat glioma显示文摘 | Ikezaki K Black K L Conklin S G | 1992 | Neurol Res1992，14，： | 1 |
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