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您的检索式：作者名="Congping Chen"
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| 1 | Adaptive optics two-photon microscopy enables near-diffraction-limited and functional retinal imaging in vivo显示文摘In vivo fundus imaging offers non-invasive access to neuron structures and biochemical processes in the retina.However,optical aberrations of the eye degrade the imaging resolution and prevent visualization of subcellular retinal structures.We developed an adaptive optics two-photon excitation fluorescence microscopy(AO-TPEFM)system to correct ocular aberrations based on a nonlinear fluorescent guide star and achieved subcellular resolution for in vivo fluorescence imaging of the mouse retina.With accurate wavefront sensing and rapid aberration correction,AOTPEFM permits structural and functional imaging of the mouse retina with submicron resolution.Specifically,simultaneous functional calcium imaging of neuronal somas and dendrites was demonstrated.Moreover,the timelapse morphological alteration and dynamics of microglia were characterized in a mouse model of retinal disorder.In addition,precise laser axotomy was achieved,and degeneration of retinal nerve fibres was studied.This highresolution AO-TPEFM is a promising tool for non-invasive retinal imaging and can facilitate the understanding of a variety of eye diseases as well as neurodegenerative disorders in the central nervous system. | Zhongya Qin Sicong He Chao Yang Jasmine Sum-Yee Yung Congping Chen Christopher Kai-Shun Leung Kai Liu Jianan Y.Qu | 2020 | Light(Science & Applications)2020，9，1： | 4 |
| 2 | High-resolution two-photon transcranial imaging of brain using direct wavefront sensing显示文摘Imaging of the brain in its native state at high spatial resolution poses major challenges to visualization techniques.Two-photon microscopy integrated with the thinned-skull or optical clearing skull technique provides a minimally invasive tool for in vivo imaging of the cortex of mice without activating immune response and inducing brain injury.However,the imaging contrast and spatial resolution are severely compromised by the optical heterogeneity of the skull,limiting the imaging depth to the superficial layer.In this work,an optimized configuration of an adaptive optics two-photon microscope system and an improved wavefront sensing algorithm are proposed for accurate correction for the aberrations induced by the skull window and brain tissue.Using this system,we achieved subcellular resolution transcranial imaging of layer 5 pyramidal neurons up to 700μm below pia in living mice.In addition,we investigated microglia–plaque interaction in living brain of Alzheimer’s disease and demonstrated high-precision laser dendrotomy and single-spine ablation. | CONGPING CHEN ZHONGYA QIN SICONG HE SHAOJUN LIU SHUN-FAT LAU WANJIE WU DAN ZHU NANCY Y.IP JIANAN Y.QU | 2021 | Photonics Research2021，9，6： | 2 |
| 3 | A Novel Crack Detection Algorithm of Underwater Dam Image显示文摘 | Chen Congping Wang Jian Zou Lei | 2012 | International Conference on Systems and Informatics(ICSAI)2012，，： | 1 |
| 4 | 社交学习时嗅觉记忆中僧帽细胞依赖胰岛素样生长因子的突触可塑性显示文摘工作与资助文章简介在食物偏好的社交传递(STFP)中,小鼠能对社交伙伴带来的食物气味形成长时程记忆。传统观点认为,记忆的形成和维持发生在海马和大脑皮层。课题组应用分子遗传学和膜片钳电生理技术,发现小鼠的社交学习记忆依赖于嗅觉神经元释放的类胰岛素生长因子(IGF1)。 | Zhihui Liu Zijun Chen Congping Shang Fei Yan Yingchao Shi Jiajing Zhang Baole Qu Hailin Han Yanying Wang Dapeng Li Thomas C.Südhof 曹鹏 | 2018 | 科学新闻2018，0，4： | 0 |
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