|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Arabidopsis F-box gene FOA1 involved in ABA signaling显示文摘The expression of FOA1(F-box overexpressed/oppressed ABA signaling) in different organs of Arabidopsis,and in response to ABA and NaCl,was analyzed.The expression level of FOA1 is higher in the root and is lower in the stem,and is induced rapidly by ABA and NaCl.The phenotypes of T-DNA insertion mutant foa1 and FOA1 overexpression lines FOA1ox1 and FOA1ox2 were analyzed.The foa1 mutant exhibited a lower germination rate,shorter root length,more stomatal opening,increased proline accumulation and hypersensitivity to ABA compared with the wild type.In contrast,the overexpression lines showed lower sensitivity to ABA than the wild type.The expression levels of several ABA and stress-responsive transcription factors and genes were altered in the foa1 mutant in response to ABA.Compared with the wild type,the expression levels of ABA-responsive transcription factors were higher,but ABA and stress-responsive genes were lower in foa1 mutant.This study demonstrates that FOA1 is an ABA signaling-related gene,and may play a negative role in ABA signaling. | PENG Juan YU DaShi WANG LiQun XIE MinMin YUAN CongYing WANG Yu TANG DongYing ZHAO XiaoYing LIU XuanMing | 2012 | Science China(Life Sciences)2012，55，6： | 12 |
| 2 | Plate subduction, oxygen fugacity, and mineralization显示文摘Plate subduction is the largest natural factory that processes elements,which controls recycling and mineralization of a variety of elements.There are three major ore deposit belts in the world:the circumPacific,the centralAsian,and the Tethys belts.All the three belts are closely associated with plate subductions,the mechanism remains obscure.We approached this problem from systematic studies on the behaviours of elements during geologic processes.This contribution summaries the recent progress of our research group.Our results suggest that porphyry Cu deposits form through partial melting of subducted young oceanic crust under oxygen fugacities higher than AFMQ^+1.5,which is promoted after the elevation of atmospheric oxygen at ca.550 Ma.Tin deposits are associated with reducing magmatic rocks formed as a consequence of slab rollback.The Neo-Tethys tectonic regime hosts more than 60%of the world's total Sn reserves.This is due to the reducing environment formed during the subduction of organic rich sediments.For the same reason,porphyry Cu deposits formed in the late stages during the closure of the Neo-Tethys Ocean.Tungsten deposits are also controlled by slab rollback,but is not so sensitive to oxygen fugacity.Subduction related W/Sn deposits are mostly accompanied by abundant accessory fluorites due to the breakdown of phengite and apatite.Decomposition of phengite is also significant for hard rock lithium deposits,whereas orogenic belt resulted from plate subduction promote the formation of Li brine deposits.Cretaceous red bed basins near the Nanling region are favorable for Li brines.Both Mo and Re are enriched in the oxidationreduction cycle during surface processes,and may get further enriched once Mo-,Re-enriched sediments are subducted and involved in magmatism.During plate subduction,Mo and Re fractionate from each other.Molybdenum is mainly hosted in porphyry Mo deposits and to a less extent,porphyry Cu-Mo deposits,whereas Re is predominantly hosted in porphyry Cu-Mo deposits and sedimentary sulfide deposits. | LIU He LIAO Renqiang ZHANG Lipeng LI Congying SUN Weidong | 2020 | Journal of Oceanology and Limnology2020，38，1： | 10 |
| 3 | Performance of biotrickling filters packed with structured or cubic polyurethane sponges for VOC removal显示文摘Two identical bench-scale biotrickling filters (BTFs),BTF 1 and BTF 2,were evaluated for toluene removal at various gas empty bed contact times (EBCTs) and organic loadings.BTF 1 and BTF 2 were packed with structured and cubic synthetic polyurethane sponges,respectively.At a constant toluene loading of 16 g/(m 3 ·hr),toluene removal efficiencies decreased from 98.8% to 64.3% for BTF 1 and from 98.4% to 74.1% for BTF 2 as gas EBCT decreased from 30 to 5 sec.When the toluene loading increased from 35 to 140 g/(m 3 ·hr) at a gas EBCT of 30 sec,the removal efficiencies decreased from 99.1% to 77.4% for BTF 1 and from 99.0% to 81.5% for BTF 2.The pressure drop for both BTFs increased with increased air flow rate,and did not significantly vary while the toluene loading was increased under similar operation conditions.BTF 1 and BTF 2 could start up successfully within 19 and 27 days,respectively,when packed with fresh sponge media,and the performances could be restored in 3-7 days after biomass was removed and wasted from the media.BTF 2 displayed higher removal efficiency even under shorter EBCT or higher loading rate than BTF1 when other operation conditions were similar,while it showed lower pressure drop than BTF 1 during the whole period of operation.These results demonstrated that both BTFs could treat waste gas containing toluene effectively. | Chunping Yang Guanlong Yu Guangming Zeng Haining Yang Fayuan Chen Congying Jin | 2011 | Journal of Environmental Sciences2011，23，8： | 10 |
| 4 | Double perovskite oxides Sr_2Mg_(1-x)Fe_xMoO(6-δ) for catalytic oxidation of methane显示文摘The double perovskite oxides Sr2Mg1-xF exMoO6-δ were investigated as catalysts for the methane oxidation.The structural properties of catalysts were characterized in detail by X-ray diffraction,X-ray photoelectron spectroscopy and X-ray absorption spectroscopy.The catalytic property was strongly influenced by the Fe substitution.The relation between catalytic performance and the degree of Fe substitution was examined with regard to the structure and surface characteristics of the mixed oxides.The Fe-containing catalysts exhibited higher activity attributable to the possible(Fe2+,Mo6+) and (Fe3+,Mo5+)valency pairs,and the highest activity was observed for Sr2Mg0.2Fe0.8MoO6-δ.The enhancement of the catalytic activity may be correlated with the Fe-relating surface lattice oxygen species and was discussed in view of the presence of oxygen vacancies. | Chen Li Wendong W ang Congying Xu Yuanxu Liu BO He Chusheng Chen | 2011 | Journal of Natural Gas Chemistry2011，20，4： | 6 |
| 5 | Cell-free plasma hypermethylated CASZ1, CDH13 and ING2 are promising biomarkers of esophageal cancer显示文摘Identifying sensitive and specific biomarkers for early detection of cancer is immensely imperative for early diagnosis and treatment and better clinical outcome of cancer patients. This study aimed to construct a specific DNA methylation pattern of cancer suppressor genes and explore the feasibility of applying cell-free DNA based methylation as a biomarker for early diagnosis of esophageal squamous cell carcinoma(ESCC). We recruited early stage ESCC patients from Yangzhong County, China. The Illumina Infinium 450 K Methylation BeadChip was used to construct a genome-wide DNA methylation profile. Then, differentiated genes were selected for the validation study using the Sequenom MassARRAY platform. The frequency of methylation was compared between cancer tissues, matched cell-free DNAs and normal controls. The specific methylation profiles were constructed, and the sensitivity and specificity were calculated. Seven CG sites in three genes CASZ1, CDH13 and ING2 were significantly hypermethylated in ESCC as compared with normal controls. A significant correlation was found between the methylation of DNA extracted from cancer tissues and matched plasma cell-free DNA, either for individual CG site or for cumulative methylation analysis. The sensitivity and specificity reached 100% at an appropriate cut-point using these specific methylation biomarkers. This study revealed that aberrant DNA methylation is a promising biomarker for molecular diagnosis of esophageal cancer. Hypermethylation of CASZ1,CDH13 and ING2 detected in plasma cell-free DNA can be applied as a potential noninvasive biomarker for diagnosis of esophageal cancer. | Huanqiang Wang Congying Yang Siyuan Wang Tian Wang Jingling Han Kai Wei Fucun Liu Jida Xu Xianzhen Peng Jianming Wang | 2018 | The Journal of Biomedical Research2018，32，6： | 6 |
| 6 | Uniformly grown PtCo-modified C03O4 nanosheets as a highly efficient catalyst for sodium borohydride electrooxidation显示文摘 | Congying Song Dongming Zhang Bin Wang Zhuang Cai Peng Yan Yang Sun Ke Ye Dianxue Cao Kui Cheng Guiling Wang | 2016 | Nano Research2016，9，11： | 5 |
| 7 | Plate convergence in the Indo-Pacific region显示文摘The Indo-Pacific convergence region is the best target to solve the teo remaining challenges of the plate tectonics theory,i.e.,subduction initiation and the driving force of plate tectonics.Recent studies proposed that the Izu-Bonin subduction initiation belongs to spontaneous initiation,which implies that it started from extension,followed by low angle subduction.Numerical geodynamic modeling suggests that the initiation of plate subduction likely occurred along a transform fault,which put the young spreading ridge in direct contact with old oceanic crust.This,however,does not explain the simultaneous subduction initiation in the west Pacific region in the Cenozoic.Namely,the subduction initiations in the Izu-BoninMariana,the Aleutian,and the Tonga-Kermadec trenches are associated with oceanic crusts of different ages,yet they occurred at roughly the same time,suggesting that they were all triggered by a maj or change in the Pacific plate.Moreover,low angle subduction induces compression rather than extension,which requires external compression forces.Given that the famous Hawaiian-Emperor bending occurred roughly at the same time with the onset of westward subductions in the west Pacific,we propose that these Cenozoic subductions were initiated by the steering of the Pacific plate,which are classified as induced initiation.Induced subduction initiation usually occurs in young ocean basins,forming single-track subduction.The closure s of Neo-Tethys Oceans were likely triggered by plume s in the south,forming northward subductions.Interestingly,the Indian plate kept on moving northward more than 50 Ma after the collision between the Indian and Eurasian continents and the break-off of the subducted oceanic slab attached to it.This strongly suggests that slab pull is not the main driving force of plate tectonics,whereas slab sliding is. | SUN Weidong ZHANG Lipeng LIAO Renqiang SUN Saijun LI Congying LIU He | 2020 | Journal of Oceanology and Limnology2020，38，4： | 4 |
| 8 | Lock threshold deterioration induced by antenna vibration and signal coupling effects in hypersonic vehicle carrier tracking system of Ka band显示文摘The envelope of a hypersonic vehicle is affected by severe fluctuating pressure, which causes the airborne antenna to vibrate slightly. This vibration mixes with the transmitted signals and thus introduces additional multiplicative phase noise. Antenna vibration and signal coupling effects as well as their influence on the lock threshold of the hypersonic vehicle carrier tracking system of the Ka band are investigated in this study. A vibration model is initially established to obtain phase noise in consideration of the inherent relationship between vibration displacement and electromagnetic wavelength. An analytical model of the Phase-Locked Loop(PLL), which is widely used in carrier tracking systems, is established. The coupling effects on carrier tracking performance are investigated and quantitatively analyzed by imposing the multiplicative phase noise on the PLL model. Simulation results show that the phase noise presents a Gaussian distribution and is similar to vibration displacement variation. A large standard deviation in vibration displacement exerts a significant effect on the lock threshold. A critical standard deviation is observed in the PLL of Binary Phase Shift Keying(BPSK) and Quadrature Phase Shift Keying(QPSK) signals. The effect on QPSK signals is more severe than that on BPSK signals. The maximum tolerable standard deviations normalized by the wavelength of the carrier are 0.04 and 0.02 for BPSK and QPSK signals,respectively. With these critical standard deviations, lock thresholds are increased from à12 andà4 d B to 3 and à2 d B, respectively. | Congying ZHU Lei SHI Xiaoping LI Yanming LIU Wei AI | 2018 | Chinese Journal of Aeronautics2018，31，4： | 4 |
| 9 | Magnetic Fe_3O_4-Reduced Graphene Oxide Nanocomposites-Based Electrochemical Biosensing显示文摘An electrochemical biosensing platform was developed based on glucose oxidase(GOx)/Fe3O4-reduced graphene oxide(Fe3O4-RGO) nanosheets loaded on the magnetic glassy carbon electrode(MGCE).With the advantages of the magnetism, conductivity and biocompatibility of the Fe3O4-RGO nanosheets, the nanocomposites could be facilely adhered to the electrode surface by magnetically controllable assembling and beneficial to achieve the direct redox reactions and electrocatalytic behaviors of GOx immobilized into the nanocomposites. The biosensor exhibited good electrocatalytic activity, high sensitivity and stability. The current response is linear over glucose concentration ranging from 0.05 to 1.5 m M with a low detection limit of0.15 μM. Meanwhile, validation of the applicability of the biosensor was carried out by determining glucose in serum samples. The proposed protocol is simple, inexpensive and convenient, which shows great potential in biosensing application. | Lili Yu Hui Wu Beina Wu Ziyi Wang Hongmei Cao Congying Fu Nengqin Jia | 2014 | Nano-Micro Letters2014，6，3： | 4 |
| 10 | Ag@Au core/shell triangular nanoplates with dual enzyme-like properties for the colorimetric sensing of glucose显示文摘Due to the serious harm of diabetes to human health,development of sensitive assays for glucose level is of high significance for early prevention and treatment of diabetes.Currently,most conventional enzyme-based glucose sensors suffer from high cost and low stability due to the inherent defects of natural enzymes.Herein,we develop a pure nanozyme-based glucose detection method using Ag@Au core/shell triangular nanoplates(TNPs),which combines glucose oxidase(GOD)-and horseradish peroxidase(HRP)-like activities of the Au shell and inherent plasmonic properties of Ag TNPs.The sensing mechanism is based on the fact that the Au shell possessed GOD-like activity,enabling the oxidation of glucose to produce H2O2,which can further etch the silver core,leading to the decrease of absorbance at 800 nm and the color change from blue to colorless.Compared with the previous nanozymes-based glucose sensors,our method avoids the use of enzymes and organic chromogenic agent.Moreover,the stability of the Ag@Au core/shell TNPs is much better than that of Ag TNPs due to the protection by the coating of the Au shell.This method was successfully applied to the detection of urine samples from patients with diabetes,indicating its practical applicability for real sample analysis. | Ao Liu Mengmeng Li Jingxiang Wang Fan Feng Yu Zhang Zhiwei Qiu Yuzhu Chen Benjamin Edem Meteku Congying Wen Zifeng Yan Jingbin Zeng | 2020 | Chinese Chemical Letters2020，31，5： | 3 |
| 11 | NAMPT-targeting PROTAC promotes antitumor immunity via suppressing myeloid-derived suppressor cell expansion显示文摘Nicotinamide phosphoribosyl transferase(NAMPT) is considered as a promising target for cancer therapy given its critical engagement in cancer metabolism and inflammation.However,therapeutic benefit of NAMPT enzymatic inhibitors appears very limited,likely due to the failure to intervene nonenzymatic functions of NAMPT.Herein,we show that NAMPT dampens antitumor immunity by promoting the expansion of tumor infiltrating myeloid derived suppressive cells(MDSCs) via a mechanism independent of its enzymatic activity.Using proteolysis-targeting chimera(PROTAC) technology,PROTAC A7 is identified as a potent and selective degrader of NAMPT,which degrades intracellular NAMPT(iNAMPT) via the ubiquitin-proteasome system,and in turn decreases the secretion of extracellular NAMPT(eNAMPT),the major player of the non-enzymatic activity of NAMPT.In vivo,PROTAC A7 efficiently degrades NAMPT,inhibits tumor infiltrating MDSCs,and boosts antitumor efficacy.Of note,the anticancer activity of PROTAC A7 is superior to NAMPT enzymatic inhibitors that fail to achieve the same impact on MDSCs.Together,our findings uncover the new role of enzymatically-independent function of NAMPT in remodeling the immunosuppressive tumor microenvironment,and reports the first NAMPT PROTAC A7 that is able to block the pro-tumor function of both iNAMPT and eNAMPT,pointing out a new direction for the development of NAMPT-targeted therapies. | Ying Wu Congying Pu Yixian Fu Guoqiang Dong Min Huang Chunquan Sheng | 2022 | Acta Pharmaceutica Sinica B2022，12，6： | 3 |
| 12 | Neuron stem cell NLRP6 sustains hippocampal neurogenesis to resist stress-induced depression显示文摘Neurogenesis decline in hippocampal dentate gyrus(DG)participates in stress-induced depressive-like behaviors,but the underlying mechanism remains poorly understood.Here,we observed low-expression of NOD-like receptor family pyrin domain containing 6(NLRP6)in hippocampus of stress-stimulated mice,being consistent with high corticosterone level.NLRP6 was found to be abundantly expressed in neural stem cells(NSCs)of DG.Both Nlrp6 knockout(Nlrp6^(-/-))and NSCconditional Nlrp6 knockout(Nlrp6CKO)mice were susceptible to stress,being more likely to develop depressive-like behaviors.Interestingly,NLRP6 was required for NSC proliferation in sustaining hippocampal neurogenesis and reinforcing stress resilience during growing up.Nlrp6 deficiency promoted esophageal cancer-related gene 4(ECRG4)expression and caused mitochondrial dysfunction.Corticosterone as a stress factor significantly down-regulated NLRP6 expression,damaged mitochondrial function and suppressed cell proliferation in NSCs,which were blocked by Nlrp6 overexpression.ECRG4 knockdown reversed corticosterone-induced NSC mitochondrial function and cell proliferation disorders.Pioglitazone,a well-known clinical drug,up-regulated NLRP6 expression to inhibit ECRG4 expression in its protection against corticosterone-induced NSC mitochondrial dysfunction and proliferation restriction.In conclusion,this study demonstrates that NLRP6 is essential to maintain mitochondrial homeostasis and proliferation in NSCs,and identifies NLRP6 as a promising therapeutic target for hippocampal neurogenesis decline linked to depression. | Chuanfeng Tang Qiaona Wang Jingyan Shen Congying Wang Hong Ding Shiyu Wen Fan Yang Ruiqing Jiao Xingxin Wu Jianmei Li Lingdong Kong | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 3 |
| 13 | Antioxidative and immunological effects of Cyclocarya paliurus polysaccharides on the spleen injury of diabetic rats显示文摘OBJEVTIVE:To investigate the effects of Cyclocarya paliurus(C.paliurus)polysaccharides on the spleen injury of diabetic rats.METHODS:Animals were divided into 6 groups,including normal group,model group,control group,low-dose group of C.paliurus polysaccharides treatment,middle-dose group of C.paliurus polysaccharides treatment and high-dose group of C.paliurus polysaccharides treatment.Histological analysis of spleen was analyzed using hematoxilin and eosin.Levels of biological parameters and anti-oxidative enzymes were determined by spectrophotometry.Interleukin-7(IL-7)and IL-10 were measured by enzyme-linked immunosorbent assay.RESULTS:Compared with that of model group,superoxide dismutase,catalase,glutathione peroxidase,glutathione reductase level increased 78.63%(P<0.05),51.76%(P<0.05),2.95 times(P<0.01)and 41.11%(P<0.05)in the high-dose group of C.paliurus polysaccharides treatment,respectively.IL-7 and IL-10 increase 1.66(P<0.01)and 1.21 times(P<0.01)in the high-dose group of C.paliurus polysaccharides treatment,respectively.CONCLUSION:It is suggested that C.paliurus polysaccharides may play a protecting role for spleen injury of diabetic rats by enhancing the antioxidative ability and evaluating the immunity. | XIA Xichao LI Bin QIU Ju TIAN Gang CHEN Changdong LA Ming ZHANG Ke QI Jinxu LI Yanyan GAO Huashan SHAO Xiangyang SU Congying WANG Mengqi OUYANG Jingfeng | 2021 | Journal of Traditional Chinese Medicine2021，41，5： | 2 |
| 14 | Genetic diversity analysis of forty-three insertion/deletion loci for forensic individual identification in Han Chinese from Beijing based on a novel panel显示文摘Due to the virtues of no stutter peaks,low rates of mutation,and short amplicon sizes,insertion/deletion(InDei)polymorphism is an indispensable tool for analyzing degraded DNA samples from crime scenes for human identifications(Wang et al.,2021).Herein,a self-developed panel of 43 InDei loci constructed previously by our group was utilized to evaluate the genetic diversities and explore the genetic background of the Han Chinese from Beijing(HCB)including 301 random healthy individuals. | Congying ZHAO Jinlong YANG Hui XU Shuyan MEI Yating FANG Qiong LAN Yajun DENG Bofeng ZHU | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，3： | 2 |
| 15 | Free fatty acids are responsible for the hidden blood loss in total hip and knee arthroplasty显示文摘 | BaoN ZhouL CongY | 2013 | Med Hypotheses2013，81，1： | 1 |
| 16 | A New Diesel Oxy- genate Additive and Its Effects on Engine Combustion and Emission 显示文摘 | CongY F Liu S H Guo H J | 2007 | Applied Thermal Engineering2007，27，1： | 1 |
| 17 | Forty-five terawatt vortex ultrashort laser pulses from a chirped-pulse amplification system显示文摘We report on a vortex laser chirped-pulse amplification(CPA)system that delivers pulses with a peak power of 45 TW.A focused intensity exceeding 1019 W/cm2 has been demonstrated for the first time by the vortex amplification scheme.Compared with other schemes of strong-field vortex generation with high energy flux but narrowband vortex-converting elements at the end of the laser,an important advantage of our scheme is that we can use a broadband but size-limited q-plate to realize broadband mode-converting in the front end of the CPA system,and achieve high-power amplification with a series of amplifiers.This method is low cost and can be easily implemented in an existing laser system.The results have verified the feasibility to obtain terawatt and even petawatt vortex laser amplification by a CPA system,which has important potential applications in strong-field laser physics,for example,generation of vortex particle beams with orbital angular momentum,fast ignition for inertial confinement fusion and simulation of the extreme astrophysical environment. | Zhenkuan Chen Shuiqin Zheng Xiaoming Lu Xinliang Wang Yi Cai Congying Wang Maijie Zheng Yuexia Ai Yuxin Leng Shixiang Xu Dianyuan Fan | 2022 | High Power Laser Science and Engineering2022，10，5： | 1 |
| 18 | An ex vivo comparison of working length determination by 3 electronic apex locators显示文摘 | Pascon EA Marrelli M Congi O | 2009 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2009，108，3： | 1 |
| 19 | Independent lung ventilation in the postoperative management of single lung trans- plantation:case report 显示文摘 | Ruberto Franco F Zullino V Congi P | 2014 | Transplant Proc2014，46，7： | 1 |
| 20 | Direct detection of phoxim in water by two-dimensional correlation near-infrared spectroscopy combined with partial least squares discriminant analysis显示文摘 | Congying Gu Bingren Xiang Jianping Xu | 2012 | Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy2012，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员