|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | IBD5 polymorphisms in inflammatory bowel disease: Association with response to infliximab显示文摘AIM: Inflammatory bowel diseases (IBD) are multifactorial pathologies of unknown etiology. One susceptibility locus,IBD5, has been mapped to chromosome 5q31. We analyzed our Spanish cohorts of Crohn's disease (CD)and ulcerative colitis (UC) patients to determine whether this locus is associated with IBD, and to ascertain the main clinical phenotype influenced by this risk factor. The kind of interaction, either genetic heterogeneity or epistasis, between this IBD5 susceptibility region and the NOD2/CARD15 gene mutations was studied as well.Finally, ve assessed whether this locus can predict response to infliximab therapy.METHODS: A case control study was performed with 274CD and 211 UC patients recruited from a single center and 511 healthy ethnically matched controls. Two polymorphisms were genotyped in the IBD5 locus and three in the CARD15/NOD2 gene.RESULTS: Our results evidence association only with CD especially with the fistulizing phenotype and in the absence of NOD2/CARD15 variants (mutant allele frequency in patients vscontrols: OR = 2.03, 95% CI = 1.35-3.06,P<0.01). The frequency of the IBD5 homozygous mutant genotype significantly increased in CD patients lacking response to infliximab (RR = 3.88, 95% CI = 1.18-12.0,P<0.05). UC patients overall do not show association with 5q31 polymorphisms, although a similar trend to the one observed in CD is found within the worse prognosis group.CONCLUSION: The IBD5 variants may enhance an individual carrier's risk for CD, mainly in the absence of the NOD2/CARD15 mutations and in fistulizing patients.The data presented suggest the potential role of the 5q31polymorphisms as markers of response to infiiximab. | Elena Urcelay Juan Luis Mendoza Alfonso Martínez Laura Fernández Carlos Taxonera Manuel Díaz-Rubio Emilio G.de la Concha | 2005 | World Journal of Gastroenterology2005，11，8： | 4 |
| 2 | A tenant-based resource allocation model for scaling software-as-a-service applications over cloud computing infrastructures显示文摘 | ESPADAS J MOLINA A JIMENEZ G1 MOLINA M RAMIRE R CONCHA D | 2013 | Future Generation Computer Systems2013，29，1： | 1 |
| 3 | Intestinal anti-inflammatory activity of combined quercitrin and dietary dive oil supplemented with fish oil,rich in EPA and DHA(N-3) polyunsaturated fatty acids,in rats with DSS-induced colitis显示文摘 | Camuesco D Comalada M Concha A | 2006 | Clin Nutr2006，25，3： | 1 |
| 4 | Mutant IDH1enhances the production of 2-hydroxyglutarate due to its kinetic mechanism显示文摘 | Rendina A R Pietrak B Smallwood A Zhao H Z Qi H W Quinn C Adams N D Concha N Sweitzer S Schwartz B | 2013 | Biochemistry2013，52，26： | 1 |
| 5 | The global burden of occupational noise - induced hearing loss显示文摘 | NELSON D I NELSON R Y CONCHA - BARRIENTOS M etal | 2005 | Am J Ind Med2005，48，6： | 1 |
| 6 | Non- local density functional calculation of gas phase heats of formation显示文摘 | HabiboUahzadeh D Grice M E Concha M C | 1995 | Joumal of Computational Chemistry1995，16，： | 1 |
| 7 | Influence of the inducible nitric oxide synthase gene ( NOS2A ) on inflammatory bowel disease susceptibility显示文摘 | M. Carmen Martín Alfonso Martinez J. Luis Mendoza Carlos Taxonera Manuel Díaz-Rubio Miguel Fernández-Arquero Emilio G. Concha Elena Urcelay | 2007 | Immunogenetics2007，，： | 1 |
| 8 | Influence of the inducible nitric oxide synthase gene (NOS2A) on inflammatory bowel disease susceptibility显示文摘 | M. Carmen Martín Alfonso Martinez J. Luis Mendoza Carlos Taxonera Manuel Díaz-Rubio Miguel Fernández-Arquero Emilio G. Concha Elena Urcelay | 2007 | Immunogenetics2007，，11： | 1 |
| 9 | Influence of the inducible nitric oxide synthase gene (NOS2A) on inflammatory bowel disease susceptibility显示文摘 | M. Carmen Martín Alfonso Martinez J. Luis Mendoza Carlos Taxonera Manuel Díaz-Rubio Miguel Fernández-Arquero Emilio G. Concha Elena Urcelay | 2007 | Immunogenetics2007，，11： | 1 |
| 10 | Prevalence of mutations of the NOD2/CARD15 gene and relation to phenotype in Spanish patients with Crohn disease显示文摘 | J. L. Mendoza L. S. Murillo L. Ferná ndez A. S. Pe? a R. Lana E. Urcelay D. M. Cruz&hyphen Santamarí a E. G. de la Concha M. Dí az&hyphen Rubio J. Garcí a&hyphen Paredes | 2003 | Scandinavian Journal of Gastroenterology2003，，12： | 1 |
| 11 | Procalcitonin and C-reactive protein as markers of systemic inflammatory response syndrome sever- ity in critically ill children显示文摘 | Rey C Los Arcos M Concha A et d | 2007 | Intensive Care Med2007，33，3： | 1 |
| 12 | Exposure to inorganicarsenic metabolites during early human development显示文摘 | Concha G Vogler G Lezcano D | | 0，，02： | 1 |
| 13 | Intestinal anti-inflammatory activity of combined quercitrin and dietary olive oil supplemented with fish oil, rich in EPA and DHA (n-3) polyun-saturated fatty acids, in rats with DSS-induced colitis 显示文摘 | Camuesco D Comalada M Concha A | 2006 | Clinical nutrition2006，25，： | 1 |
| 14 | Extratemporal white matter abnormalities in mesial temporal lobe epilepsy demonstrated with diffusion tensor imaging 显示文摘 | Gross D W Concha L Beaulieu C | 2006 | Epilepsia2006，47，： | 1 |
| 15 | Extraction of essential oil from sambong 显示文摘 | UNALIVIA E D ANZALDO F E CONCHA J A | 1983 | NSTA Technology Journal1983，8，2： | 1 |
| 16 | In vivo diffusion tensor imaging and histopathology of the fimhria-fornix in temporal lobe epilepsy显示文摘 | Concha L Livy D J Beaulieu C | 2010 | J Neurosci2010，30，3： | 1 |
| 17 | A tenant-based resource allocation model for scaling Software-as-a-Service applications over cloud computing infrastructures显示文摘 | Espadas J Molina A Jimz G Molina M Ramz R Concha D | | Future Generation Computer0，，0： | 1 |
| 18 | The e-HUB evolution:from a custom software architecture to a software-as-a-service implementation 显示文摘 | Concha D Espadas J Romero D | 2010 | Computers in Industry2010，61，2： | 1 |
| 19 | Does the team leverage the board' s decisions? 显示文摘 | CASTRO C B DELA CONCHA M D GRAVEL J V | 2009 | Corporate Govern- ance -an International Review2009，17，6： | 1 |
| 20 | Does the team leverage the board's decisions? 显示文摘 | CASTRO C B DE LA CONCHA M D GRAVEL J V | 2009 | Corporate governance-an international review2009，17，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员