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| 1 | Personalized medicine in gastric cancer:Where are we andwhere are we going?显示文摘Despite improvements in adjuvant therapies for gastric cancer in recent years, the disease is characterized by high recurrence rates and a dismal prognosis. The major improvement in the treatment of recurrent or metastatic gastric cancer in recent years has been the incorporation of trastuzumab, a monoclonal antibody that inhibits human epidermal growth factor receptor 2(HER2) heterodimerization, after the demonstrated predictive value of the overexpression and/or amplification of this receptor. Beyond HER2, other genetic abnormalities have been identified, and these mutations may be targetable by tyrosine kinase inhibitors or monoclonal antibodies. The demonstration of four distinct molecular subtypes of gastric cancer by the Cancer Genome Atlas study highlight the enormous heterogeneity of the disease and its complex interplay between genetic and epigenetic alterations and provide a roadmap to implement genome-guided personalized therapy in gastric cancer. In the present review, we aim to discuss, from a clinical point of view, the genomic landscape of gastric cancer described in recent studies, the therapeutic insights derived from these findings, and the clinical trials that have been conducted and those in progress that take into account tailored therapies for gastric cancer. | Alexandre A Jácome Anelisa K Coutinho Enaldo M Lima Aline C Andrade JoséSebastião dos Santos | 2016 | World Journal of Gastroenterology2016，22，3： | 2 |
| 2 | Primary malignant lymphoid tum-ours of the intestinal tract,Report of 37 cases with a study of factors infl-uencing prognosis显示文摘 | Dawson I M Comes J S Morson B C | 1961 | Br J Surg1961，49，8： | 1 |
| 3 | Tribological behaviour of Si3N4-BN ceramic materials for dry sliding applications显示文摘 | Carrapichano J M Comes J R Silva R F | 2002 | Wear2002，253，： | 1 |
| 4 | Solubilities of oxygen and carbon dioxide in butyl methyl imidazolium tetrafluoroborate as a function of temperature and at pressures close to atmospheric pressure显示文摘 | Husson-Borg P Majer V Comes M F C | 2003 | J Chem Eng Data2003，48，3： | 1 |
| 5 | 显示文摘 | CORT(E)S-J(A)COME M A ESCOBAR J ANGELES CH(A)VEZ C LPEZ-SALINAS E ROMERO E FERRAT G TOLEDO-ANTONIO J A | 2008 | Catal Today2008，130，1： | 1 |
| 6 | Human visual quality criterion显示文摘 | Comes S Macq B M | 1990 | SPIE Visual Communication and Image Processing1990，1360，： | 1 |
| 7 | Trigonella foenum - graecum(fenugreek) seed extract as an antineoplastic agent 显示文摘 | Sur P Das M Comes A | 2001 | Phy - tother Res2001，15，3： | 1 |
| 8 | N- (2-Carboxyethyl) Chitosan: Regioselective Synthesis, Characterization and Protolytic Equilibria显示文摘 | Skorik Yury A Comes Carlos A R Vasconcelos M Teresa S D | 2003 | Carbohydr Res2003，338，3： | 1 |
| 9 | Highly stereoselective route toward the synthesis of α -and β- amino alcohols from homochiral α - and β - amino acylsilanes as synthetic equivalents of α - and β - amino aldehydes 显示文摘 | BONINI B F COMES -FRANCHINI M MAZZANTI G | 1996 | J Org Chem1996，61，21： | 1 |
| 10 | Frequency,seventy, and dura- tion of rhinovirus infections in asthmatics and non-asthmatic individ- uals : a longitudinal cohort study 显示文摘 | Come J M Marshall C Smith S | 2002 | Lancet2002，359，9309： | 1 |
| 11 | On the formation of the manganese maximum in the oxygen minimum 显示文摘 | Johnson K S CoMe K H Berelson W M Gordon R M | 1996 | Geochemica et Cosmochimica Acta1996，60，8： | 1 |
| 12 | Towards a monitoring method and anumber of multifaceted and hierarchical biodiversityindicators for urban and suburban parks 显示文摘 | Hermy J Comelis M | 2000 | Landscape andUrban Planning2000，49，： | 1 |
| 13 | CIP2A is associated with hu-man breast cancer aggressivity 显示文摘 | Come C Laine A Chanrion M | 2009 | Clin Cancer Res2009，15，16： | 1 |
| 14 | Optimization of biomass fuelled systems for distributed power generation using particle swarm optimization 显示文摘 | Reche Lopez P Comes G M Ruiz R N | 2008 | Electric Power Systems Research2008，78，8： | 1 |
| 15 | Biodiversity relationships in urbanand suburban park in Flanders 显示文摘 | Comelis M Hermy J | 2004 | Landsacpe and UrbanPlanning2004，69，： | 1 |
| 16 | Reversal of intestinal failure-associated liver disease in infants and children on parenteral nutrition: experience with 93 patients at a referral center for intestinal rehabilitation 显示文摘 | CoMes RA Ventura KA Martinez M | 2010 | J Pediatr Surg2010，45，1： | 1 |
| 17 | Long-term follow-up after endoscopic resection of gastric superficial neoplastic lesions in Portugal显示文摘 | Pedro Pimentel-Nunes Francisco Mour?o Nuno Veloso Luís Afonso Manuel Jácome Luís Moreira-Dias Mário Dinis-Ribeiro | 2014 | Endoscopy2014，，： | 1 |
| 18 | Highly dispersed CoMoS phase on titania nanotubes as efficient HDS显示文摘 | Cortés-Jácome M A Escobar J Angeles Chávez C | 2008 | Catalysts Catalysis Today2008，130，1： | 1 |
| 19 | structural characteriza- tion and properties of water-soluble N-( γ-propanoyl-amino acid)-chitosans 显示文摘 | COMES P GOMES C A R BATISTA M K S | 2008 | Carbohydrate Polymers2008，71，1： | 1 |
| 20 | Allocation of Reactive Power Support,Active Loss Balancing and Demand Inter- ruption Ancillary Services in MicroGrids显示文摘 | Comes M H Saraiva J T | 2010 | Electric Power Systems Research2010，80，10： | 1 |
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