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| 1 | Neoadjuvant chemotherapy for gastric cancer. Is it a must or a fake?显示文摘AIM To investigate the neoadjuvant chemotherapy(NAC) effect on the survival of patients with proper stomach cancer submitted to D2 gastrectomy.METHODS We proceeded to a review of the literature with Pub Med, Embase, ASCO and ESMO meeting abstracts as well as computerized use of the Cochrane Library for randomized controlled trials(RCTs) comparing NAC followed by surgery(NAC + S) with surgery alone(SA) for gastric cancer(GC). The primary outcome was the overall survival rate. Secondary outcomes were the site of the primary tumor, extension of node dissection according to Japanese Gastric Cancer Association(JGCA) performed in both arms, disease-specific(DSS) and disease-free survival(DFS) rates, clinical and pathological response rates and resectability rates after perioperative treatment. RESULTS We identified a total of 16 randomized controlled trials comparing NAC + S(n = 1089) with SA(n = 973) published in the period from January 1993-March 2017. Only 6 of these studies were well-designed, structured trials in which the type of lymph node(LN) dissection performed or at least suggested in the trial protocol was reported. Two out of three of the RCTs with D2 lymphadenectomy performed in almost all cases failed to show survival benefit in the NAC arm. Inthe third RCT, the survival rate was not even reported, and the primary end points were the clinical outcomes of surgery with and without NAC. In the remaining three RCTs, D2 lymph node dissection was performed in less than 50% of cases or only recommended in the 'Study Treatment' protocol without any description in the results of the procedure really perfomed. In one of the two studies, the benefit of NAC was evident only for esophagogastric junction(EGJ) cancers. In the second study, there was no overall survival benefit of NAC. In the last trial, which documented a survival benefit for the NAC arm, the chemotherapy effect was mostly evident for EGJ cancer, and more than one-fourth of patients did not have a proper stomach cancer. Additionally, several patients did not receive resectional surgery. Furthermore, the survival rates of international reference centers that provide adequate surgery for homogeneous stomach cancer patients' populations are even higher than the survival rates reported after NAC followed by incomplete surgery.CONCLUSION NAC for GC has been rapidly introduced in international western guidelines without an evidence-based medicinerelated demonstration of its efficacy for a homogeneous population of patients with only stomach tumors submitted to adequate surgery following JGCA guidelines with extended(D2) LN dissection. Additional larger sample-size multicentre RCTs comparing the newer NAC regimens including molecular therapies followed by adequate extended surgery with surgery alone are needed. | Rossella Reddavid Silvia Sofia Paolo Chiaro Fabio Colli Renza Trapani Laura Esposito Mario Solej Maurizio Degiuli | 2018 | World Journal of Gastroenterology2018，24，2： | 25 |
| 2 | Measurement of Spleen Stiffness to Evaluate Portal Hypertension and the Presence of Esophageal Varices in Patients With HCV-Related Cirrhosis显示文摘 | Antonio Colecchia Lucia Montrone Eleonora Scaioli Maria Letizia Bacchi–Reggiani Agostino Colli Giovanni Casazza Ramona Schiumerini Laura Turco Anna Rita Di Biase Giuseppe Mazzella Luca Marzi Umberto Arena Massimo Pinzani Davide Festi | 2012 | Gastroenterology2012，，3： | 3 |
| 3 | “Pseudotumoral” hepatic pattern in acute alcoholic hepatitis:A case report显示文摘In acute alcoholic hepatitis (AAH), a 'pseudotumoral' appearance of the liver parenchyma on computed tomography (CT) scan has been reported. The main findings are hypervascularized areas closely similar to those observed in large hepatocellular carcinomas. We report a case of a patient affected by AAH with an unusual appearance of these 'pseudotumoral' areas on CT scan, close resembling a metastatic cancer rather than a primary hepatocellular carcinoma. In fact, in contrast with previous reports, the picture was characterized by the presence of many inhomogeneous, hypoattenuated areas highlighted during both pre- and post-contrast phases. Moreover, we report the first description of 'pseudotumoral' lesions on ultrasound scan. This patient was successfully treated with corticosteroids, even if many controversies still exist regarding their efficacy in this setting. | Andrea Tenca Sara Massironi Agostino Colli Guido Basilisco Dario Conte | 2009 | World Journal of Gastroenterology2009，15，32： | 2 |
| 4 | Integron-encoded Intl integrases preferentially recognize the adjacent cognate attI site in recombination with a 59-be site 显示文摘 | Collis C M Kim M J Stokes H W | 2002 | Mol Microbiol2002，46，5： | 2 |
| 5 | Accuracy of a predictive model for severe hepatic fibrosis or cirrhosis in chronic hepatitis C显示文摘AIM: To assess the accuracy of a model in diagnosing severe fibrosis/cirrhosis in chronic hepatitis C virus (HCV)infection.METHODS: The model, based on the sequential combination of the Bonacini score (BS: ALT/AST ratio,platelet count and INR) and ultrasonography liver surface characteristics, was applied to 176 patients with chronic HCV infection. Assuming a pre-test probability of 35%,the model defined four levels of post-test probability of severe fibrosis/cirrhosis: <10% (low), 10-74% (not diagnostic), 75-90% (high) and >90% (almost absolute).The predicted probabilities were compared with the observed patients' distribution according to the histology (METAVIR).RESULTS: Severe fibrosis/cirrhosis was found in 67 patients (38%). The model discriminated patients in three comparable groups: 34% with a very high (>90%)or low (<10%) probability of severe fibrosis, 33% with a probability ranging from 75% to 90%, and 33% with an uncertain diagnosis (I.e., a probability ranging from 10%to 74%). The observed frequency of severe fibrosis/cirrhosis was within the predefined ranges.CONCLUSION: The model can correctly identify67% of patients with a high (>75%) or low (<10%) probability of cirrhosis, leaving only 33% of the patients still requiring liver biopsy. | Agostino Colli Alice Colucci Silvia Paggi Mirella Fraquelli Sara Massironi Marco Andreoletti Vittorio Michela Dario Conte | 2005 | World Journal of Gastroenterology2005，11，46： | 2 |
| 6 | Photoluminescence of CdSe Nanowires Grown With and Without Metal Catalyst显示文摘我们 CdSe nanowires 上的现在的温度和力量依赖者光致发光大小有或没有金属催化剂的使用经由蒸汽阶段综合了。没有催化剂,生产的 Nanowires 能被优化产出更高的量效率,和更狭窄、空间地一致的排放,当时与帮助催化剂的相比。在比乐队边低的精力的排放也在两个盒子中被发现。由在一样的 nanowires 上联合空间地解决的光致发光和电子显微镜学,我们证明没有催化剂的 nanowires 与锋利的声子复制品展出一座低精力的山峰,而为帮助催化剂的 nanowires 低精力的排放与扩大词法缺点被连接到 nanostructures 的存在。 | Andrea Fasoli Alan Colli Faustino Martelli Simone Pisana Ping Heng Tan Andrea C. Ferrari | 2011 | Nano Research2011，4，4： | 2 |
| 7 | 强迫症药物疗效与六个功能基因的分子遗传药理学研究显示文摘目的 探讨与5-羟色胺系统和多巴胺系统有关的6个基因(5-羟色胺2A受体基因、5-羟色胺转运体基因、多巴胺D2受体基因、多巴胺D4受体基因、儿茶酚胺氧位甲基转移酶基因、单胺氧化酶A基因)与强迫症药物疗效之间是否存在关联。方法 收集了113个强迫症核心家系,对强迫症患者给予5-羟色胺回吸收抑制剂治疗,采用Yale-Brown强迫量表在治疗8周前后进行评定,按Yale-Brown强迫量表评分分为有效组和无效组。采用限制性片段长度多态性和可变数串联重复序列多态性技术对有效组和无效组的强迫症家系在6个基因的7个位点上进行传递不平衡检测。结果 未发现6个基因与不同药效的强迫症家系之间存在关联,但发现有效组和无效组在5-羟色胺2A受体基因-1438G/A位点基因型频率存在差异,无效组有更多的纯合子(χ2=4.69,P=0.03)。结论 5-羟色胺2A受体基因可能和强迫症药物治疗效果有关。 | 张岚 刘协和 李涛 杨彦春 胡迅 David Collie | 2004 | 中华医学遗传学杂志2004，21，5： | 2 |
| 8 | Prohibiting state aid in an integrated market:Coumot and Bertrand oligopolies with differentiated products显示文摘 | Collie D | 2002 | Journal of Industry Competition and Trade2002，2，： | 1 |
| 9 | Comparison -of -midwife -top-ups,comtinuous infusion and pstient-controlled epidural analgesin for maintaining mobility after a low-dose combined spinal-epidural显示文摘 | Collis RE Plaat PS Morgan BM | 1999 | Br J Anaesth1999，82，2： | 1 |
| 10 | Higher - order spectra: the bispectrum and trispeetrum 显示文摘 | COLLIS W B WHITE P R HAMMOND J K | 1998 | Mechanical System and Signal Processing1998，12，3： | 1 |
| 11 | Progress to- wards identifying the neurofibromatosis ( NFI ) gene 显示文摘 | Collis FS O'Connell P Ponder BA | 1989 | Trends Genet1989，5，7： | 1 |
| 12 | Modeling Predator-Prey Dynamics in a Fluctuating Environment 显示文摘 | S Jeremy Collie D Paul Spencer | 1994 | Can J Fish Aquat Sci1994，，51： | 1 |
| 13 | The pulvinar sign in variant Creutzfeldt-Jakob disease显示文摘 | Summers DM Collie DA Zeidler M | 2004 | Arch Neurol2004，61，： | 1 |
| 14 | Mobile gene cassettes and integrons:capture and spread of genes by site specific recombination显示文摘 | Hall RM Collis CM | 2006 | Molecular Microbiology2006，15，4： | 1 |
| 15 | Imaging features of leptomeningeal metastases 显示文摘 | Collie DA Brush JP Lammie GA | 1999 | Clin Radiol1999，54，11： | 1 |
| 16 | The IGF1 pathway genes and their association with age of puber- ty in cattle显示文摘 | FORTES M R S LI Y T COLLIS E | 2015 | Animal Genetics2015，44，1： | 1 |
| 17 | Parasagiattal meningomas: follow-up review显示文摘 | Colli BO Carlotti CG Jr Assirati JA Jr | 2013 | Surg Neurol2013，66，3： | 1 |
| 18 | Gene cassettes from the insert region of integrons are excised as covalently closed circles 显示文摘 | Collis CM Hall RM | 1992 | Mol Microbiol1992，6，19： | 1 |
| 19 | The physical chemistry of WDGs:Porosity and surfactant dissolution as a function of dispersant molecular weight显示文摘 | Doering Ingomar W | 2000 | Pesticide Formulations and Application Systems2000，20，： | 1 |
| 20 | Rehardening of surface softened and surface etched enamel in vitro and by intraoral exposure显示文摘 | Collys K Cleymaet R Coomans D | 1993 | Caries Res1993，27，1： | 1 |
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