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| 1 | Blood classical monocytes phenotype is not altered in primary non-small cell lung cancer显示文摘AIM: To evaluate the M1 and M2 monocyte phenotype in patients with non-small cell lung cancer(NSCLC) compared to controls. Also, to examine the expression of Th1 and Th2 cytokines in plasma of NSCLC vs controls. METHODS: Freshly prepared peripheral blood mononuclear cells samples were obtained from patients with NSCLC(lung adenocarcinoma and squamous cell lung carcinoma) and from non-cancer controls. Flow cytometry was performed to investigate M1 and M2 phenotypes in peripheral monocytes(classical monocytes CD14+, CD45+ and CD16-) using conventional surface markers. Th1 and Th2 cytokine production was alsoanalysed in the plasma using cytometric bead array technique. RESULTS: There were no significant difference in expression of M1(HLA-DR) and/or M2 markers(CD163 and CD36) markers on classical monocytes in patients with NSCLC compared to non-cancer controls. Expression of CD11 b, CD11 c, CD71 and CD44 was also shown to be similar in patients with NSCLC compared to noncancer controls. Th1 and Th2 cytokines [interleukin(IL)-1β, IL-2, IL-4, IL-5, IL-8, IL-10, IL-12(p70), tumor necrosis factor(TNF)-α, TNF-β, and interferon-γ] analysis revealed no significant difference between patients with NSCLC and non-cancer controls. CONCLUSION: This study shows no alteration in peripheral monocyte phenotype in circulating classical monocytes in patients with NSCLC compared to noncancer controls. No difference in Th1 and Th2 cytokine levels were noted in the plasma of these patients. | Saleh A Almatroodi Christine F Mc Donald Allison L Collins I an A Darby Dodie S Pouniotis | 2014 | World Journal of Clinical Oncology2014，5，5： | 2 |
| 2 | The National Institutes of Health chronic prostatitis symptom index:development and validation of a new outcome measure显示文摘 | Litwin MS Mc Naughton collins M Fowler FJ | 1999 | J Urol1999，162，： | 1 |
| 3 | Radiographic differentiation of enchondroma from low-grade chondrosarcoma in the fibu la显示文摘 | Kendell SD Collins MS Adkins MC | 2004 | Skeletal Radiol2004，33，8： | 1 |
| 4 | Higher protein and energy intake isassociated with increased weight gain in preterm infants显示文摘 | Collins CT Chua MC Rajadurai VS | 2010 | J Paediatr Child Health2010，46，3： | 1 |
| 5 | Template boundary definition in Tetrahymena telomerase 显示文摘 | Lai CK Miller MC Collins K | 2002 | Genes Dev2002，16，4： | 1 |
| 6 | The NIH chronic prostatitis symptom index (NIH- CPSI)development and validation of a new outcome measure显示文摘 | Litwin SM Mc Naughton- Collins M Fowlor FJ | 1999 | Jurol1999，152，： | 1 |
| 7 | Impaired fasting glucose tolerance in first-episode, drug-naive patients with schizophrenia 显示文摘 | Ryan MC Collins P Thakore JH | 2003 | Am J Psychiatry2003，160，2： | 1 |
| 8 | Anhydri- demodlfie cantharidin analogues : Synthesis, inhibition of protein phosphatases 1 and 2A and anticanceractivity 显示文摘 | Mc Cluskey A Bowyer M C Collins E et a/ | 2000 | Bioorg Med Chem Lett2000，10，： | 1 |
| 9 | Impaired fasting glucose tolerance in first-episode,drug-nave patiences with schizophrenia显示文摘 | Ryan MC Collins P Thakore JH | 2003 | Am J Psychiatry2003，160，： | 1 |
| 10 | Anhydride modified cantharidin analogues: synthesis, inhibition of protein phosphatases 1 and 2A and anticancer activity显示文摘 | McCluskey A Bowyer MC Collins E | 2000 | Bioorg Med Chem Lett2000，10，： | 1 |
| 11 | Pathology teachand tell:Castleman disease显示文摘 | Collins GL Wallis-Crespo MC Gilbert-Barness E | 2004 | Fetal Pediatr Pathol2004，23，1： | 1 |
| 12 | Radiographic differen- tiation of enehondroma from low-grade ehondrosarcoma in the fib- ula显示文摘 | SD Kendell MS Collins MC Adkins | 2004 | Skeletal Radiol2004，33，： | 1 |
| 13 | A smallcell predominant variant of primary Ki-1 (CD30) + T-cell lym phoma 显示文摘 | Kinney MC Collins RD Greet PJ | 1993 | Am J SurgPathol1993，17，9： | 1 |
| 14 | Accurate,noninvasive diagnosis of human brain tumors by using proton magnetic resonance spectroscopy显示文摘 | Preul Mc Caramanos Z Collins DL | 1996 | Nat Med1996，2，3： | 1 |
| 15 | Early cell loss asso-ciated with mesenchymal stem cells cardiomyoplasty 显示文摘 | Collins MC Moore Jr JL Burrows BJ | 2012 | OpenTissue Eng Regen Med J2012，5，1： | 1 |
| 16 | Pathology teach and tell:Castleman disease显示文摘 | Collins GL Wallis-Crespo MC Gilbert-Barness E | 2004 | Fetal Pediatr Pathol2004，23，1： | 1 |
| 17 | Pathology teach and tell: Castleman disease显示文摘 | Collins GL Wallis - Crespo MC Gilbert - Barness E | 2004 | Fetal Pediat Pathol2004，23，： | 1 |
| 18 | Radiographic differentiation of enchondroma from low-grade chondrosarcoma in the fibula显示文摘 | Kendell SD Collins MS Adkins MC | 2004 | Skeletal Radiol2004，33，： | 1 |
| 19 | Higher protein and energy intake is associated with increased weight gain in preterm infants显示文摘 | Collins CT Chua MC Rajadurai VS | 2010 | J Paediatr Child Health2010，46，3： | 1 |
| 20 | Pathology teach and tell: Castleman disease显示文摘 | Collins GL Wallis2Crespo MC Gilbert2Barness E | 2004 | Fetal Pediatr Pathol2004，23，1： | 1 |
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