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1688篇 您的检索式：作者名="Collins E"

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	题名	作者	年代	出处	被引量
1	The hypoxia-inducible factor-1α activates ectopic production of fibroblast growth factor 23 in tumor-induced osteomalacia显示文摘Tumor-induced osteomalacia(TIO) is a rare paraneoplastic syndrome in which ectopic production of fibroblast growth factor 23(FGF23) by non-malignant mesenchymal tumors causes phosphate wasting and bone fractures. Recent studies have implicated the hypoxia-inducible factor-1α(HIF-1α) in other phosphate wasting disorders caused by elevated FGF23, including X-linked hypophosphatemic rickets and autosomal dominant hypophosphatemia. Here we provide evidence that HIF-1α mediates aberrant FGF23 in TIO by transcriptionally activating its promoter. Immunohistochemical studies in phosphaturic mesenchymal tumors resected from patients with documented TIO showed that HIF-1α and FGF23 were co-localized in spindleshaped cells adjacent to blood vessels. Cultured tumor tissue produced high levels of intact FGF23 and demonstrated increased expression of HIF-1α protein. Transfection of MC3T3-E1 and Saos-2 cells with a HIF-1α expression construct induced the activity of a FGF23 reporter construct. Prior treatment of tumor organ cultures with HIF-1α inhibitors decreased HIF-1α and FGF23 protein accumulation and inhibited HIF-1α-induced luciferase reporter activity in transfected cells. Chromatin immunoprecipitation assays confirmed binding to a HIF-1α consensus sequence within the proximal FGF23 promoter, which was eliminated by treatment with a HIF-1α inhibitor. These results show for the first time that HIF-1α is a direct transcriptional activator of FGF23 and suggest that upregulation of HIF-1α activity in TIO contributes to the aberrant FGF23 production in these patients.	Qian Zhang Michele Doucet Ryan E Tomlinson Xiaobin Han L Darryl Quarles Michael T Collins Thomas L Clemens	2016	Bone Research2016，4，2：	6
2	Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors显示文摘	Li M Lee KF Lu Y Clarke I Shih D Eberhart C Collins VP Van Meter T Picard D Zhou L Boutros PC Modena P Liang ML Scherer SW Bouffet E Rutka JT Pomeroy SL Lau CC Taylor MD Gajjar A Dirks PB Hawkins CE Huang A.	2009	中国神经肿瘤杂志2009，7，4：	3
3	CD133,a novel marker for human prostatic epithelial stem cells显示文摘	Richardson G D Robson C N Lang S H Neal D E Maitland N J Collins A T	2004	J Cell Sci2004，117，16：	1
4	Increasing an tioxidant levels in tomatoes through modification of the flavonoid biosynthetic pathway 显示文摘	Verhoeyen M E Bovy A Collins G	2002	J Exp Bot2002，53，：	1
5	Estrus synchronization and artificial insemination of hair sheep ewes in the tropics显示文摘	Godfrey R W Collins J R Hensley E L	1999	Theriogenology1999，51，：	1
6	Simplified modi- fied compression field theory for calculating shear strength of reinforced concrete elements 显示文摘	Bentz E C Vecehio F J Collins M P	2006	ACI Structural Journal2006，103，4：	1
7	Isolation of swine infertility and respiratory syndrome virus(isolate ATCC VR-2332)in North America and experimental reproduction of the disease in gno-tobiotic pigs 显示文摘	Collins J E Benfield D A Christianson W T	1992	Journal of Veterinary Diagnostic Investigation1992，4，2：	1
8	Soil carbon pools and fluxes in lung-term corn belt agroeeosystems 显示文摘	COLLINS H P ELLIOTT E T PAUSTIAN K	2000	Soil Biology and Biochemistry2000，32，2：	1
9	Iso-lation of swine infertility and respiratory syndrome vi-rus (isolate ATCC VR22332) in North America andexperimental reproduction of the disease in gnotobiot-ic pigs显示文摘	Collins J E Benfield D A Christianson W T	1992	Vet Diagn Invest1992，4，2：	1
10	The loss of species: mangrove extinction risk and geographic areas of global concern 显示文摘	POLIDORO B A CARPENTER K E COLLINS L	2010	PLoS ONE2010，，5：	1
11	Antigen selection in IgE antibode from individual with chronic rhinosinusitis with nasal polyps 显示文摘	Pratt E Collins AM Sewell WA	2010	Am J Rhinol Allergy2010，24，6：	1
12	Warfarin therapy that results in an International Nor- malization Ratio above the therapeutic range is associated with accelerated progression of chronic kidney disease 显示文摘	Brodsky SV Collins M Park E	2010	Nephron Clin Pract2010，115，2：	1
13	Lrig1 expression defines a distinct multi potent stem cell显示文摘	Jensen KB Collins CA Nascimento E	2009	Cell Stem Cell2009，4，5：	1
14	Semiextended position of intramedullary nailing of the proximal tibia显示文摘	Tornetta P III Collins E	1996	Clin Orthop Relat Res1996，328，：	1
15	Crop rotation and residue management effects on soil carbon and microbial dynamics 显示文摘	Collins H P Rasmussen P E Douglas C L	1992	Soil Science Society of America Journal1992，56，3：	1
16	Nonlinear viscoelastic behavior of butadiene acrylonitrile copolymers filled with carbon black显示文摘	Nakajima N Bowerman H H Collins E A	1978	Rubber Chemistry and Technology1978，51，2：	1
17	Effects of raloxifene on cardiovascular events and breast cancer in postmenopausal women显示文摘	Barrett-Connor E Mosca L Collins P		0，，2：	1
18	Dual-energy subtraction chest radiography: what to look for beyond calcified nodules 显示文摘	Kuhlman J E Collins J Brooks G N	2006	Radiographys2006，26，1：	1
19	Porcine sperm zona binding ability as an indicator of fertility显示文摘	COLLINS E D FLOWERS W L SHANKS R D	2008	Anim Re- prod Sci2008，104，1：	1
20	Isolation of swine infertility and respiratory syndrome virus (isolate ATCC VR- 2322) in North America and experiment reproduction of the disease in gnotobiotie pigs显示文摘	Collins J E Benfield D A Christianmn W T	1992	J Vet Diagn Invest1992，4，2：	1

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