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| 1 | FibroSURE^(TM) and FibroScan~ in relation to treatment response in chronic hepatitis C virus显示文摘AIM:To compare histological endpoint assessment using noninvasive alternatives to biopsy during treatment in a chronic hepatitis C virus(HCV)cohort.METHODS:Patients with chronic HCV were randomized to receive interferon-based therapy for 24(genotypes 2/3)or 48(genotype 1)wk.FibroSURE~TM(FS)was assessed at baseline and at week-12 post-treatment follow-up.Baseline biopsy for METAVIR was assessed by a single pathologist.FibroScan~ transient elastogra-phy(TE)was performed during treatment in a patient subset.RESULTS:Two thousand and sixty patients(n = 253 in Asia)were classif ied as METAVIR F0-1(n = 1682)or F2-4(n = 378).For F2-4,FS(n = 2055)had sensitiv-ity and specif icity of 0.87 and 0.61,respectively,with area under the receiver-operating curve of 0.82;corre-sponding values for TE(n = 214)and combined FS/TE(n = 209)were 0.77,0.88 and 0.88,and 0.93,0.68 and 0.88.Overall FS/TE agreement for F2-4 was 71%(κ = 0.41)and higher in Asians vs non-Asians(κ = 0.86 vs 0.35;P < 0.001).Combined FS/TE had 97% accuracy in Asians(n = 33).Baseline FS(0.38 vs 0.51,P < 0.001)and TE(8.0 kPa vs 11.9 kPa,P = 0.006)scores were lower in patients with sustained virological response than in nonresponders,and were maintained through follow-up.CONCLUSION:FS and TE may reliably differentiate mild from moderate-advanced disease,with a potential for high diagnostic accuracy in Asians with chronic HCV. | Keyur Patel Mireen Friedrich-Rust Yoav Lurie Mircea Grigorescu Carol Stanciu Chuan-Mo Lee Eugene R Schiff Dieter Hussinger Michael P Manns Guido Gerken Isabelle Colle Michael Torbenson Erik Pulkstenis G Mani Subramanian John G McHutchison Stefan Zeuzem | 2011 | World Journal of Gastroenterology2011，17，41： | 4 |
| 2 | Resonance light scattering: a new technique for studying chromophore aggregation 显示文摘 | PASTERNACK R F COLLINGS P J | 1995 | Science1995，269，： | 1 |
| 3 | Image selective smoothing and edge detection by nonlinear diffusion 显示文摘 | CATTE F COLL T LIONS P L | 1992 | SIAM Journal on Nu- merical Analysis1992，29，1： | 1 |
| 4 | Ajugatansins,neo-clerodane diterpenes from Ajuga reptans显示文摘 | Carbonell P Coll J | 2001 | Phytochem Anal2001，12，1： | 1 |
| 5 | Porphrin Assemblies on DNA as Studied by a Resonaee Light-Scattering Teehnique显示文摘 | Pasternack R F Bustamante C Collings P J | 1993 | J Am Chem Soc1993，115，13： | 1 |
| 6 | Protein kinase Cδ-dependent phosphorylation of syndecan-4 regulates cell migration显示文摘 | Chaudhuri P Colles SM Fox PL Graham LM | 2005 | Circ Res2005，97，7： | 1 |
| 7 | Porphyrin Assemblies on DNA as Studied by a Resonance Light-scattering Technique显示文摘 | Pasternack R F Bustmante C Collings P J | 1993 | J Am Chem Soc1993，115，： | 1 |
| 8 | International HRM inthe 21st century: Emerging themes and contemporary debates 显示文摘 | SCUllION H COllINGS D G GUNNGlE P | 2007 | Human Resource Management Journal2007，17，4： | 1 |
| 9 | Preimplantation genetic diag- nosis for gender selection in the USA显示文摘 | Colls P Silver L Olivera G | 2009 | Reprod Biomed On- line2009，19，2： | 1 |
| 10 | Image selective smoothiung and edge detection by nonlinear diffusion 显示文摘 | CATFE F LIONS P L MOREL J M COLL T | 1992 | Society for Industrial and Applied Mathematics Journal of Numerical Analysis1992，29，1： | 1 |
| 11 | A model - based method for indoor mobile robot localization using monocu- lar vision and straight - line correspondences显示文摘 | Aider O A Hoppenot P Colle E | 2005 | Robotics and Autonomous Systems2005，，52： | 1 |
| 12 | Elucidation of a TRPC6- TRPC5 channel cascade that restricts endothelial cell movement显示文摘 | Chaudhuri P Colles SM Bhat M | 2008 | Mol Biol Cell2008，19，8： | 1 |
| 13 | 查看详情显示文摘 | Pastrnack P F Collings P J | | 0，，： | 1 |
| 14 | Purification and characterization of a phenoloxidase ( laccase from the lignin-degrading basidiomycete PM1 ( CECT2971 ) 显示文摘 | Coll P M Fernandez-Abalos J M Villanieva J R | 1993 | Appl Environ Microbiol1993，59，18： | 1 |
| 15 | Resonance light scattering: A new technique for studying chromophore aggregation显示文摘 | Pastenack R F Collings P J | 1995 | Science1995，269，： | 1 |
| 16 | The effective density and fractal dimension of particles emitted from a light - duty diesel ve- hicle with a diesel oxidation catalyst 显示文摘 | Olfert J S Symonds J P R Collings N | 2007 | Journal of Aerosol Sci- ence2007，38，26： | 1 |
| 17 | Chromosome segregation in a man heterozygous for a pericentric inversion,inv(9)(p11q13),analyzed by using sperm karyotyping and two-color fiuorescence in situ hybridization on sperm nuclei显示文摘 | COLLS P BLLANCO J MARTINEZ-PASARELL O | 1997 | Hum Genet1997，99，6： | 1 |
| 18 | Resonance light scattering: a new technique for studying chromophore aggregation 显示文摘 | PASTERNACK R F COLLINGS P J | 1995 | Science1995，269，5226： | 1 |
| 19 | Loss of control is central to psychological disturbance associated with binge eating disorder显示文摘 | COLLES S L DIXON J B O'BRIEN P E | 2008 | Obesity2008，16，3： | 1 |
| 20 | Institutional Theory and the Cross-national Transfer of Employment Policy:the Case of' Workforce Diversity' in US Multinationals 显示文摘 | Ferner A P Almond T Colling | 2005 | Journal of International Business Studies2005，36，3： | 1 |
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