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3篇 您的检索式：作者名="Colin Sumners"

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		题名	作者	年代	出处	被引量
	1	PI_3激酶参与AT_1受体介导Ang II调节SHR脑神经元电活动的信号转导显示文摘目的探索AT1受体介导AngII调节SHR和WKY鼠脑神经元电活动的信号转导机制。方法原代培养SHR和WKY新生鼠脑干和下丘脑神经元 ,用全细胞膜片钳以电流箝方式记录神经元的放电活动 ,观察AngII及各种信号分子抑制剂对脑神经元放电频率的影响。结果 AngⅡ (10 0nmol·L-1)可使WKY新生鼠脑神经元的放电频率从 (0 .4 4± 0 .0 8)Hz增加到 (1.39± 0 .16 )Hz。这种效应在SHR鼠更加显著。由AngⅡ引起的这两种鼠脑神经元放电频率的增加均可被AT1受体拮抗剂Losartan完全消除。使用PKC抑制剂calphostinC和钙调蛋白激酶II抑制剂KN 93能完全阻断AngⅡ对WKY鼠脑神经元的作用 ,但对SHR鼠脑神经元的放电频率仅阻抑约 5 0 %。磷脂酰肌醇 3(PI3 )激酶抑制剂LY2 94 0 0 2 (10 μmol·L-1)对SHR鼠脑神经元的放电频率可产生部分阻断作用 ,但对WKY鼠脑神经元无明显影响。结论 AngII增加SHR和WKY鼠脑神经元放电频率的作用均由AT1受体介导。PI3	杜剑青孙成文唐敬师 Colin Sumners Mohan K Raizada	2003	西安交通大学学报(医学版)2003，24，6：	2
	2	Oxygen and Glucose Deprivation-Induced Neuronal Apoptosis is Attenuated by Halothane and Isoflurane显示文摘	Lisa Wise-Faberowski Mohan K. Raizada Colin Sumners	2001	Anesthesia & Analgesia2001，，5：	1
	3	EFFECT OF ANGIOTENSIN Ⅱ RECEPTOR SUBTYPE ⅠON THE FIRING RATE IN CATECHOLAMINERGIC TUMOR CELLS显示文摘Objective To study the action of brain angiotensin Ⅱ(Ang Ⅱ) receptors and underlying intracellular mechanism in the catecholaminergic system Methods Action potentials (APs) of the primary co cultured catecholaminergic tumor (CATH.a) cells were recorded with the whole cell patch clamp configuration in current clamp mode. Expression of Ang Ⅱ receptors subtypes (AT 1 and AT 2 ) was detected by RT PCR technique. Results The differentiated CATH.a cells represented a neuron like characterization. All CATH.a cells expressed mRNA encoding both Ang Ⅱ AT 1 and AT 2 receptor subtypes. Ang Ⅱ increased the firing rate in the CATH.a cells, which was inhibited completely by addition administration of the AT 1 but not AT 2 receptor antagonist, and partially by using the inhibitors of signal molecules, U73122 (10 μmol·L -1 ), or KN 93 (10 μmol·L -1 ), or calphostin C (10 μmol·L -1 ). Conclusion Ang Ⅱ increases firing rate in CATH.a cells via AT 1 receptor. The CATH.a cells expressing functional AT 1 and AT 2 receptor subtypes may be of general utility for the study of the Ang Ⅱ receptor induced modulation of brain catecholaminergic system.	杜剑青孙成文唐敬师 Colin Sumners MohanK Raizada	2003	Journal of Pharmaceutical Analysis2003，15，2：	0

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