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| 1 | PrP^C-related signal transduction is influenced by copper, membrane integrity and the alpha cleavage site显示文摘铜绑定,抛锚膜的、细胞的 prion 蛋白质(PrPC ) 有二个组成的劈开地点生产不同 N 终端和 C 终端碎片(N1/C1 和 N2/C2 ) 。用表示也人的 PrPC,鼠标 PrPC 或鼠标 PrPC 的 RK13 房间带 3F4 epitope,这研究在 endoproteolytic 劈开和一个通常认为的 PrPC 函数上探索了 PrPC 主要顺序的影响,地图 kinase 信号 transduction,响应外长的铜与或没有使不安的膜环境。PrPC 主要顺序,特别在 N1/C1 劈开地点附近,看起来在这个地点和细胞外的调整信号的 kinase 1/2 (ERK1/2 ) phosphorylation 影响解朊作用的基础层次,与处理激活增加与基础 ERK1/2 表明一种反的关系。人的 PrPC 独自响应铜显示出增加的 N1/C1 劈开,由特定的 p38 和 JNK/SAPK phosphorylation 伴随了。到加扣押胆固醇的抗菌素 filipin 的铜的联合暴露导致了一只老鼠信号蛋白质 phosphorylation 的 PrPC 特定的实质的增加,由 N1/C1 劈开的增加伴随了。怀有人的 N1/C1 劈开地点的老鼠 PrPC 基础地并且响应铜假定更似人类的侧面并且改变了膜环境。我们的结果证明在 N1/C1 劈开地点附近的 PrPC 主要顺序影响在这个地点处理的 endoproteolytic,它显得连接了基础地并且响应铜印射 kinase 信号 transduction。进一步,主要顺序看起来响应外长的刺激在 PrPC 相关的信号 transduction 的忠实上授与 N1/C1 劈开和膜完整的相互的依赖。 | Cathryn L Haigh | 2009 | Cell Research2009，19，9： | 4 |
| 2 | Damage to the corneal endothelium from anterior chamber intraocular lenses in phakic myopic eyes显示文摘 | Mimouni F Colin J Koffi V | 1991 | Refract Corn Surg1991，7，： | 2 |
| 3 | Intrastriatal injection of and adenoviral vector expressing glial cell line-derived neurotrophic factor prevents dopaminergic neuron degeneration and behavioral impairment in a rat model of Parkinson disease显示文摘 | Bleuel AB Revah F Colin P | 1997 | Proc Natl Acad Sci USA1997，94，16： | 1 |
| 4 | Proteolysis in samples of quarter milk with varying somatic cell counts显示文摘 | LE ROUX Y COLIN O LAURENT F | 1995 | Dairy Sci1995，78，： | 1 |
| 5 | Altemeier's procedure for rectal prolapse: analysis of long-term outcome in 60 patients 显示文摘 | Ris F Colin JF Chilcott M | 2012 | Colorectal Dis2012，14，： | 1 |
| 6 | Survey of background levels of PCDDs and PCDFs in UK soils显示文摘 | Colin S C Alwyn R F Ameera A H | 1989 | Chemosphere1989，18，16： | 1 |
| 7 | Murine Denys - Drash syndrome: evi dence of podocyte de - differentiation and systemic mediation of glomerul - oselerosis 显示文摘 | Charles E P Stewart F Colin G M | 2003 | Human Molecular Genetics2003，12，18： | 1 |
| 8 | Peripherally inserted central catheter (PICC) fracture and embolozation in the pediatric popula- tion显示文摘 | Lionel C Jeremy F Colin MA | 2003 | The Journal of Pediatrics2003，142，2： | 1 |
| 9 | Comparison of vildagliptin and pioglitazone in patients with type 2 diabetes inadequately controlled with metformin显示文摘 | Bolli G Dotta F Colin L | | 0，，： | 1 |
| 10 | Assessment of two objective voice function indices显示文摘 | Piccirillo J Colin P Dennis F | 1998 | Ann Otol Rhinol Laryngol1998，107，： | 1 |
| 11 | Application of carbohydrases in extracting protein from rice bran显示文摘 | Anshamllah James A Hourigan Colin F Chesterman | | 0，，： | 1 |
| 12 | Detrital fine grained sediment contribution from Taiwan to the northern South China Sea and its relation to regional ocean cireulation显示文摘 | LIU Z F TUO S T COLIN C | 2008 | Marine Geology2008，255，： | 1 |
| 13 | Distribution of water in sludges in relation to their mechanical dewatering 显示文摘 | COLIN F GAZBAR S | 1995 | Water Research1995，，29： | 1 |
| 14 | Predicting the number, death, and self- pruning of branches in Scots pine显示文摘 | Makinen H Colin F | 1999 | Canadian Journal of Forest Research1999，29，8： | 1 |
| 15 | Methods for the evaluation of the maturity of municipal refuse compost显示文摘 | Morel J Colin F Germon J | 1985 | Composting of agricultural and other wastes/edited by JKR Gasser1985，，： | 1 |
| 16 | Methods for the evaluation of the maturity of municipal refuse compost显示文摘 | Morel T L Colin F Germon J | 1985 | Composting of Agricultural and Other Wastes1985，5672，： | 1 |
| 17 | Modelling crown shape of Picea abies : spacing effects 显示文摘 | Deleuze C Herve J C Colin F | 1996 | Canadian Journal of Forest Research1996，，26： | 1 |
| 18 | Development and feasibility of a scale to assess postoperative recovery the post-ope rative quality recovery scale显示文摘 | COLIN F ROYSE B S NEWMAN S | | 0，，04： | 1 |
| 19 | Assessing risk from contaminated sites: policy and practice in 16 European countries 显示文摘 | Colin C F | 1999 | Land Con- tamination and Reclamation1999，7，2： | 1 |
| 20 | Hot needle thermal keratoplasty to correct naturally occurring hyperopic astigmatism 显示文摘 | Charpentier DY Bertel F Duplessix M colin J Denis P | 1996 | J Refract Surg1996，12，6： | 1 |
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