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| 1 | Evaluation of quantitative contrast harmonic imaging to assess malignancy of liver tumors:A prospective controlled two-center study显示文摘AIM: To establish the extent to which contrast enhancement with SonoVue in combination with quantitative evaluation of contrast-medium dynamics facilitates the detection of hepatic tumors. METHODS: One hundred patients with histologically confirmed malignant or benign hepatic tumor (maximum size 5 cm) were analyzed. Contrast-enhanced ultrasound (bolus injection 2.5 mL SonoVue) was carried out with intermittent breath-holding technique using a multifrequency transducer (2.5-4 MHz). Native vascularization was analyzed with power Doppler. The contrast-enhanced dynamic ultrasound investigation was carried out with contrast harmonic imaging in true detection mode during the arterial,portal venous and late phases. Mechanical index was set at 0.15. Perfusion analysis was performed by post-processing of the raw data time intensity curve (TIC) analysis. The cut-off of the gray value differences between tumor and normal liver tissue was established using Receiver Operating Characteristic (ROC) analysis 64-line multi-slice computed tomography served as reference method in all cases. Magnetic resonance tomography was used additionally in 19 cases. RESULTS: One hundred patients with 59 malignant (43 colon,5 breast,2 endocrine metastases,7 hepatocellular carcinomas and 2 kidney cancers) and 41 benign (15 hemangiomas,7 focal nodular hyperplasias,5 complicated cysts,2 abscesses and 12 circumscribed fatty changes) tumors were included. The late venous phase proved to be the most sensitive for classification of the tumor type. Fifty-eight of the 59 malignant tumors were classified as true positive,and one as false negative. This resulted in a sensitivity of 98.3%. Of the 41 benign tumors,37 were classified as true negative and 4 as false negative,which corresponds to a specificity of 90.2%. Altogether,95.0% of the diagnoses were classified as correct on the basis of the histological classification. No investigator-dependency (P = 0.23) was noted. CONCLUSION: The results show the possibility of accurate prediction of malignancy of hepatic tumors with a positive prognostic value of 93.5% using advanced contrast-enhanced ultrasound. Contrast enhancement with SonoVue in combination with quantitative evaluation of contrast-medium dynamics is a valuable tool to discriminate hepatic tumors. | EM Jung DA Clevert AG Schreyer S Schmitt J Rennert R Kubale S Feuerbach F Jung | 2007 | World Journal of Gastroenterology2007，13，47： | 15 |
| 2 | Improved carotid athero- seleretic plaques imaging with contrast- enhaneed ultrasound (CEUS) 显示文摘 | Clevert DA Sommer WH Helek A | 2011 | Clinical Hemorheology and Mieroeireulation2011，48，1： | 1 |
| 3 | Contrast enhanced ultrasound and Dual Source CT of left atrial myxoma显示文摘 | Clevert DA Schweyer M Johnson T | 2007 | Ultraschall Med2007，28，6： | 1 |
| 4 | Imaging of aortic abonr malities with contrast--enhanced ultrasound A pictorial compari son with CT显示文摘 | Clevert DA Sticka IM Johnson T | 2007 | Eur Radio J2007，17，11： | 1 |
| 5 | Multislice com- puted tomography versus contrast enhanced ultrasound in evaluation of complex cystic renal masses using the Bosniak classification system显示文摘 | Clevert DA Minaifar N Weekhach S | 2008 | Clin Hemorheol Microcirc2008，39，1： | 1 |
| 6 | Evaluation of Acoustic Radiation Force Impulse (ARFI) imaging and contrast-enhanced ultrasound in renal tumors of unknown etiology in comparison to histological findings显示文摘 | Clevert DA Stock K Klein B | 2009 | Clin Hemorheol Microcirc2009，43，12： | 1 |
| 7 | Imaging of aortic lesions with color coded duplex sonography and contrast enhanced ul trasound versus multislice computed tomography (MS CT) an giography显示文摘 | Clevert DA Weckbach S Kopp R | 2008 | Clin Hemorheol Microcirc2008，40，4： | 1 |
| 8 | Color Doppler, power Doppler and B -flow ultrasound in the assessment of ICA stenosis: Comparison with 64 - MD - CT angiography 显示文摘 | Clevert DA Johnson T Jung EM | 2007 | EurRadiol2007，17，8： | 1 |
| 9 | Image fusion in the management of thermal tumor ablation of the liver显示文摘 | Clevert DA Paprottka PM Helck A | 2012 | Clin Hemorheol Microcirc2012，52，24： | 1 |
| 10 | Multislice computed to - mography versus contrast- enhanced ultrasound in evaluation of complex cystic renal mas- ses using the Bosniak classification system显示文摘 | Clevert DA Minaifar N Weckhach S | 2008 | Clin Hemorheol Microcirc2008，39，14： | 1 |
| 11 | Diagnostic algorithm in cystic renal masses显示文摘 | Clevert DA Horng A Staehler M et d | 2010 | Urologe A2010，49，3： | 1 |
| 12 | Multislice computed to-mography versus contrast-enhanced ultrasound in evaluation ofcomplex cystic renal masses using the Bosniak classification system显示文摘 | Clevert DA Minaifar N Weckbach S | 2008 | Clin Hemorheol Microcirc2008，39，14： | 1 |
| 13 | Improved diagnosis of vascular dissection by ultrasound B-flow:a comparison with color-coded Doppler and power Doppler sonography 显示文摘 | Clevert DA Rupp N Reiser M | 2005 | Eur Radiol2005，15，2： | 1 |
| 14 | Contrast enhanced ultrasound in liver transplant:first results and potential for complications in the postoperative period显示文摘 | Clevert DA Stickel M Minaifar N | 2009 | Clin Hemorheol Micro2009，43，1： | 1 |
| 15 | Image fusion in themanagement of thermal tumor ablation of the liver 显示文摘 | Clevert DA* Paprottka PM Helck A | 2012 | ClinHemorheol Microcirc2012，52，24： | 1 |
| 16 | Imaging of carotid arterialdiseases with contrast-enhanced ultrasound (CEUS) 显示文摘 | Clevert DA Sommer WH Zengel P | 2011 | Eur J Radi-ol2011，80，1： | 1 |
| 17 | Contrast-enhanced ultrasound versus CT and operative findings in evaluation of renal vein aneurysm with AV fistula显示文摘 | Clevert DA Stickel M Kopp R | | 0，，： | 1 |
| 18 | Magnetic resonance imaging-guided focused ultrasound treatment of symptomatic uterine fibroids: impact of technology advancement on ablation volumes in 115 patients显示文摘 | Trumm CG Stahl R Clevert DA | 2013 | Invest Radiol2013，48，6： | 1 |
| 19 | Evaluation of Acoustic Ra-diation Force Impulse(ARFI)imaging and contrast-enhancedultrasound in renal tumors of unknown etiology in comparison tohistological findings显示文摘 | Clevert DA Stock K Klein B | 2009 | Clin Hemorheol Microcirc2009，43，12： | 1 |
| 20 | Reiser Improved carotid atherosclerotic plaques imaging with contrast-enhanced ultrasound (CEUS) 显示文摘 | Clevert DA Sommer WH Helck A | 2011 | Clinical Hemorheology and Microcirculation2011，48，： | 1 |
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