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| 1 | Long-term stability of gentamicin sulfate-ethylenediaminetetraacetic acid disodium salt (EDTA-Na_2) solution for catheter locks显示文摘A lock solution composed of gentamicin sulfate(5 mg/mL) and ethylenediaminetetraacetic acid disodium salt(EDTA-Na2, 30 mg/mL) could fully eradicate in vivo bacterial biofilms in totally implantable venous access ports(TIVAP). In this study, fabrication, conditioning and sterilization processes of antimicrobial lock solution(ALS) were detailed and completed by a stability study. Stability of ALS was conducted for12 months in vial(25 °C 7 2 °C, 60% 7 5% relative humidity(RH), and at 40 °C 7 2 °C, RH 75% 7 5%)and for 24 h and 72 h in TIVAP(40 °C 7 2 °C, RH 75% 7 5%). A stability indicating HPLC assay with UV detection for simultaneous quantification of gentamicin sulfate and EDTA-Na2 was developed. ALS was assayed by ion-pairing high performance liquid chromatography(HPLC) needing gentamicin derivatization, EDTA-Na2 metallocomplexation of samples and gradient mobile phase. HPLC methods to separate four gentamicin components and EDTA-Na2 were validated. Efficiency of sterility procedure and conditioning of ALS was confirmed by bacterial endotoxins and sterility tests. Physicochemical stability of ALS was determined by visual inspection, osmolality, pH, and sub-visible particle counting. Results confirmed that the stability of ALS in vials was maintained for 12 months and 24 h and 72 h in TIVAP. | Anne-Sophie Fiolet Elise Jandot Pauline Doucey Coralie Crétet Célia Brunel Christine Pivot Jean-Marc Ghigo Christophe Beloin David Lebeaux Fabrice Pirot | 2018 | Journal of Pharmaceutical Analysis2018，8，6： | 2 |
| 2 | Halovirs A-E, New Antiviral Agents from a Marine- Derived Fungus of the Genus Scytalidium 显示文摘 | David CR Sara K Christopher AK | 2003 | Bioorganic & Medicinal Chemistry2003，11，： | 1 |
| 3 | Thalassiolins A-C: New Marine-Derived Inhibitors of HIV cDNA Integrase 显示文摘 | David CR Mark STH Denise R | 2002 | Bioorganic & Medicinal Chemistry2002，10，： | 1 |
| 4 | The NIH human microbiome project显示文摘 | NIH HMP Working Group Peterson J Garges S Giovanni M McInnes P Wang L Schloss JA Bonazzi V McEwen JE Wetterstrand KA Deal C Baker CC Di Francesco V Howcroft TK Karp RW Lunsford RD Wellington CR Belachew T Wright M Giblin C David H Mills M Salomon R Mullins C Akolkar B Begg L Davis C Grandison L Humble M Khalsa J Little AR Peavy H Pontzer C Portnoy M Sayre MH Starke-Reed P Zakhari S Read J Watson B Guyer M | 2009 | Genome Res2009，19，12： | 1 |
| 5 | Strong antibacterial properties of anion transporters:a result of depolarization and weakening of the bacterial membrane显示文摘 | Elie CR David G Schmitzer AR | 2015 | J Med Chem2015，58，5： | 1 |
| 6 | Uptake of antioxidants in surfactant liposomes by cultured alveolar type Ⅱ cells is enhanced by SP-A显示文摘 | Walther FJ David CR Supnet MC | 1993 | Am J Physiol1993，265，41： | 1 |
| 7 | Hope and the meaningful life: theoreticaland empirical associations between goal-directed thinking and lifemean- ing 显示文摘 | David BF Snyder CR | 2005 | J Soc Clin Psychol2005，24，3： | 1 |
| 8 | Osteogenie protein-1 biology and applications显示文摘 | Stephen DC David CR | 1996 | Clin Orthop1996，324，3： | 1 |
| 9 | Hope and the meaningful life: theoretical and empirical associations Between goal-dirocted thinking and life meaning显示文摘 | David BF Snyder CR | 2005 | Journal of Social and ClinicalPsychology2005，24，3： | 1 |
| 10 | Pelvic endometriosis: infertility and pelvic pain 显示文摘 | I GARC1A CR DAVID SS | 1977 | American Journal of Obstetrics and Gynecology1977，129，7： | 1 |
| 11 | Osteogenic protein-1 biology and applications 显示文摘 | Stephen DC David CR | 1996 | Clin Orthop1996，324，： | 1 |
| 12 | 4,5-Diaryl-lH-pyrrole- 2-carboxvlates as combretastatin A-4/lamellarin T hybrids: Synthesis and evaluation as anti-mitotic and cytotnxic agents 显示文摘 | Martin GB Ernest H David CR | 2006 | Bioorg & Med Chem2006，14，13： | 1 |
| 13 | Reduction in medication errors in hospitals due to adoption of computerized provider order entry systems显示文摘 | David CR Melanie RW Lauren EW | 2013 | J Am Med Inform Assoc2013，20，： | 1 |
| 14 | Delayed hemothorax resulting from stab wounds tothe internal mammary artery显示文摘 | David CR Frederic CC | 1995 | JTrauma1995，，39： | 1 |
| 15 | 建设恢复力和适应性以对付北极的变化显示文摘人类行为引起的空前的全球变化挑战着社会支撑我们这颗行星保持自身优点的能力。这就要求对变化进行主动的管理以培养地球的恢复力——维持在变化的情况下对社会很重要的一些属性,和适应性——发展新的社会生态构造以便在新的条件下有效地发挥作用。北极的广大地区仍然完整地保留着原型的生态及社会过程及反馈,这为我们为变化预先做出计划提供了可能是最后一个实验的机会。如果该策略的可行性在北极可以被证实,我们对于变化的动态所得到的进一步的理解就可以实施到那些被人类较大地改变了的地区中。现在执行管理北极变化的政策的条件可能很理想,因为近来的研究提供了极其重要的科学知识,合适的国际机制也已各就各位,而且,如果北极地区的国家选择这样做的话,他们具备实行必要改变的财力。 | F.Stuart Chapin Ⅲ Michael Hoel Steven R.Carpenter Jane Lubchenco Brian Walker Terry V.Callaghan Carl Folke Simon A.Levin Karl-Gran Mler Christer Nilsson Scott Barrett Fikret Berkes Anne-Sophie Crépin Kjell Danell Thomas Rosswall David Starrett Anastasios Xepapadeas Sergey A.Zimov 陈卓天 | 2006 | AMBIO-人类环境杂志2006，35，4： | 1 |
| 16 | Avoiding and treating perioperative complications of distal radius fractures review article显示文摘 | Peter CR David GD Sanjeev K | | 0，，02： | 1 |
| 17 | Disordered regulation of coagulation and platelet activation in xenotransplantation显示文摘 | Simon CR David KCC Anthony JF | 2000 | Xenotransplantation2000，7，3： | 1 |
| 18 | Mental disordersacross the adult life course and future coronary heart disease:evidence for general susceptibility显示文摘 | Gale CR G David B Osborn DPJ | 2014 | Circulation2014，129，2： | 1 |
| 19 | Detection of the multidrug resistance marker P-glycopeotein by immuno-histochemistry in malignant lung tumors 显示文摘 | Trevor WB David CR Crocker J | 1996 | Thorax1996，51，： | 1 |
| 20 | Analysis of tear glucose concentration with electrospray ionization mass spectrometry 显示文摘 | Taormina CR Baca JT David N | 2007 | J Am Soc Mass Spectrum2007，18，2： | 1 |
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